DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and ZSCAN21

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_001349708.1	Gene:	ZSCAN21 / 7589	HGNCID:	13104	Length:	473	Species:	Homo sapiens

Alignment Length:	582	Identity:	127/582 - (21%)
Similarity:	195/582 - (33%)	Gaps:	188/582 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 PEIIKLATQEEEGVTEP------QELGGRNFFY----------------------PEIKIEEHEL 136
            |.::|:..:||:|...|      |..  |.|.|                      |||..:|..|
Human    23 PLMVKVEEKEEKGKYLPSLEMFRQRF--RQFGYHDTPGPREALSQLRVLCCEWLRPEIHTKEQIL 85

  Fly   137 DTLPRIEIL-----ERSANTQEN-QDQLEGAARRLRKRLKAEDGSSVDKDKDEDGVEETAEPAPP 195
            :.|...:.|     |..|..||: .:..|.|...|      ||   ::::.||.|.:.:   .||
Human    86 ELLVLEQFLTILPQELQAWVQEHCPESAEEAVTLL------ED---LERELDEPGHQVS---TPP 138

  Fly   196 KKRR---------GRPRKSDAAVAPPQKPKE---------DIQLDLKAEELDEFVDEETDPDFSC 242
            .:::         |..::|.:::.|  :|.|         .:.:....||.:...|.....|...
Human   139 NEQKPVWEKISSSGTAKESPSSMQP--QPLETSHKYESWGPLYIQESGEEQEFAQDPRKVRDCRL 201

  Fly   243 LVPSDNSSEDDGGS--DGFDSDSDFELDNGKQEFAVLPKRTVVRPKKYKKRTKP--AEPKVRMSR 303
            ....:.|:::..||  :|...|....:...|.| |.|.::.|  ..:.:|.|||  .|...:..|
Human   202 STQHEESADEQKGSEAEGLKGDIISVIIANKPE-ASLERQCV--NLENEKGTKPPLQEAGSKKGR 263

  Fly   304 ELLEQRKKQQEEYDVIIAKFFTSVLPCAICNLLVHNFTEMQRHHRLTHQVDPGYMMCCGRKFTQR 368
            |.:..:....|...:           ||.|.....|.:.:.:|.| ||..:..|:
Human   264 ESVPTKPTPGERRYI-----------CAECGKAFSNSSNLTKHRR-THTGEKPYV---------- 306

  Fly   369 KVLAEHVLVHWNPDHFKCSVCEKSFQNSRHLESHQQVHMDPAVKLTFSCDLCSKTFLSKTAIDYH 433
                             |:.|.|:|.:|.:|..|.:.|:   |...:.|
Human   307 -----------------CTKCGKAFSHSSNLTLHYRTHL---VDRPYDC---------------- 335

  Fly   434 KLNKHVPKSEFKFTCSECNKKFLTERKLKNHMSSMHDPESTIICDKCGKQMRTKIILKKHQELMH 498
                            :|.|.|.....|..| ..||..|:...|..|||....|..|.:|..:..
Human   336 ----------------KCGKAFGQSSDLLKH-QRMHTEEAPYQCKDCGKAFSGKGSLIRHYRIHT 383

  Fly   499 SDKPRPEPELQQCQICGAWLKGMTGLKQHMKSIHVESAGEHRCHICAKVSPNARALRRHIYHNHE 563
            .:||      .||..||.......||..|.:.                               |.
Human   384 GEKP------YQCNECGKSFSQHAGLSSHQRL-------------------------------HT 411

  Fly   564 CERKFKCTMCEKAFKRPQELKEHTSTHTGEVLYTCPNCPMTFFCSANMYKHRQRLHRAQYEA 625
            .|:.:||..|.|||.......:|...||||..|.|.:|..||...:|:.|| ||:|..:.||
Human   412 GEKPYKCKECGKAFNHSSNFNKHHRIHTGEKPYWCHHCGKTFCSKSNLSKH-QRVHTGEGEA 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856	16/96 (17%)
		C2H2 Zn finger	330..351	CDD:275368	6/20 (30%)
		C2H2 Zn finger	360..378	CDD:275368	0/17 (0%)
		LIM	361..>400	CDD:295319	5/38 (13%)
		C2H2 Zn finger	386..406	CDD:275368	7/19 (37%)
		zf-C2H2_8	389..465	CDD:292531	13/75 (17%)
		C2H2 Zn finger	417..438	CDD:275368	1/20 (5%)
		C2H2 Zn finger	448..465	CDD:275368	4/16 (25%)
		C2H2 Zn finger	477..498	CDD:275368	7/20 (35%)
		C2H2 Zn finger	511..532	CDD:275368	6/20 (30%)
		C2H2 Zn finger	541..562	CDD:275368	0/20 (0%)
		C2H2 Zn finger	570..590	CDD:275368	6/19 (32%)
		C2H2 Zn finger	598..619	CDD:275368	9/20 (45%)
ZSCAN21	NP_001349708.1	SCAN	42..153	CDD:128708	25/124 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	127..169		10/46 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	244..272		7/27 (26%)
		COG5048	<276..453	CDD:227381	59/288 (20%)
		C2H2 Zn finger	279..299	CDD:275368	6/20 (30%)
		C2H2 Zn finger	307..327	CDD:275368	7/19 (37%)
		C2H2 Zn finger	337..354	CDD:275368	5/17 (29%)
		C2H2 Zn finger	362..382	CDD:275368	7/19 (37%)
		C2H2 Zn finger	390..410	CDD:275368	6/50 (12%)
		C2H2 Zn finger	418..438	CDD:275368	6/19 (32%)
		C2H2 Zn finger	446..466	CDD:275368	9/20 (45%)
		zf-C2H2	446..466	CDD:395048	9/20 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910