DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and zbtb11

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_012813021.2	Gene:	zbtb11 / 734142	XenbaseID:	XB-GENE-988913	Length:	1117	Species:	Xenopus tropicalis

Alignment Length:	639	Identity:	154/639 - (24%)
Similarity:	235/639 - (36%)	Gaps:	156/639 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 SSLQETKVALMEDDPLTQETTSFPEIIKLATQEEEGVTEPQELGGRNFFYPEIKIE------EHE 135
            |::||.: .::.|.|....|...||             ..|...|.|...|:..:.      |.:
Frog   432 SNVQEHQ-QILGDTPEDSTTAEHPE-------------SQQSTAGSNMDVPDEVLSVTCTTTEEK 482

  Fly   136 L---DTLPRIEILERSANTQENQDQLEGAARRLRKRLKAEDGS----SVDKDKDEDGVEETAEPA 193
            |   |..|:...::...|:..|.|......       .||:.|    .::....||.|....:|.
Frog   483 LPADDPQPKDVSMKELINSSTNGDPQVSVP-------VAEESSISVIDLETTCAEDVVIGNTDPD 540

  Fly   194 P-------PKKRRGRPRKSDAAVAPPQKPKEDIQLDLKAEELDEFVDEETDPD----------FS 241
            |       ||::|||||||          .||::...|.       ..||.|.          ..
Frog   541 PEAKIGEVPKRKRGRPRKS----------PEDVEKSCKE-------TRETLPSGGKCTYKGKLRD 588

  Fly   242 CLVPSDNSSEDDGGSDGF----------------DSDSDFE------LDNGKQEFAVLPKRTVVR 284
            |||          |..|:                :..|..:      |..||::..::||:.:..
Frog   589 CLV----------GKGGYIMLHRGQEKALKKRKANPKSAVQQAAMKLLQRGKKKRLMVPKKQIAE 643

  Fly   285 PK---------------------KYKKR--------TKPAEPKVRMSRELLEQRKKQQEEYDVII 320
            .:                     |::|.        ||..:.:..:...|:...|..:.|.:|:.
Frog   644 AQFKCNDCGMMFQRRYALIMHSVKHEKSKEFKCPLCTKEFQYRASLRAHLIRHSKTGKAEVNVVE 708

  Fly   321 AKFFTS------VLPCAICNLLVHNFTEMQRHHRLTHQ-VDPGYMMCCGRKFTQRKVLAEHVLVH 378
            .:..|:      ...|.||...:.....: |.|.|.|. |.|.....||:.||.:..|..|..:|
Frog   709 TEADTAKGGTKRQFICGICGRTLPKLYSL-RIHMLKHTGVKPHACEVCGKTFTHKHGLKMHQALH 772

  Fly   379 WNPDHFKCSVCEKSFQNSRHLESHQQVHMDPAVKLTFSCDLCSKTFLSKTAIDYHKLNKHVPKSE 443
            .:...|||.:|||||..:|.|:.|...|...:   .:.|.:|.|.|...:.:..| |.||.||.|
Frog   773 ESHKQFKCDMCEKSFVTNRSLQEHVSTHTGES---KYLCSVCGKAFHRASGLSKH-LKKHKPKVE 833

  Fly   444 FK-FTCSECNKKFLTERKLKNHMSSMHDPESTIICDKCGKQMRTKIILKKHQELMHSDKPRPEPE 507
            .: :.|::|.|.|...|.|:.||:. |.......|:.|||....|.....|.      |.....|
Frog   834 TRGYHCTQCEKSFFELRDLQQHMNK-HLGVKPFECEFCGKCYSWKKDWYSHV------KSHSVTE 891

  Fly   508 LQQCQICGAWLKGMTGLKQHM-KSIHVESAG-----EHRCHICAKVSPNARALRRHIYHNHECER 566
            ..:|.:||.........::|: |:.|.:...     |..|..|.|:....|..|||: :|||..:
Frog   892 PYRCSVCGKEFYEKALYRRHVNKATHGKKGRTKLNFEKACEHCGKIFTQFREYRRHV-NNHEGVK 955

  Fly   567 KFKCTMCEKAFKRPQELKEHTSTHTGEVLYTCPNCPMTFFCSANMYKHRQRLHR 620
            .|:|..|..|:...:.||.|..|||||..|.||.|...:..:..:.||..:.|:
Frog   956 PFECLTCGVAWADARSLKRHVRTHTGERPYVCPVCNEGYIDARTLRKHMTKTHK 1009

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071	1/3 (33%)
		FYDLN_acid	<191..268	CDD:302856	23/115 (20%)
		C2H2 Zn finger	330..351	CDD:275368	6/20 (30%)
		C2H2 Zn finger	360..378	CDD:275368	6/17 (35%)
		LIM	361..>400	CDD:295319	16/38 (42%)
		C2H2 Zn finger	386..406	CDD:275368	9/19 (47%)
		zf-C2H2_8	389..465	CDD:292531	26/76 (34%)
		C2H2 Zn finger	417..438	CDD:275368	6/20 (30%)
		C2H2 Zn finger	448..465	CDD:275368	6/16 (38%)
		C2H2 Zn finger	477..498	CDD:275368	6/20 (30%)
		C2H2 Zn finger	511..532	CDD:275368	5/21 (24%)
		C2H2 Zn finger	541..562	CDD:275368	7/20 (35%)
		C2H2 Zn finger	570..590	CDD:275368	6/19 (32%)
		C2H2 Zn finger	598..619	CDD:275368	5/20 (25%)
zbtb11	XP_012813021.2	Integrase_H2C2	68..122	CDD:407771
		BTB_POZ_ZBTB11	193..310	CDD:349511
		C2H2 Zn finger	648..668	CDD:275370	0/19 (0%)
		C2H2 Zn finger	676..696	CDD:275368	3/19 (16%)
		C2H2 Zn finger	724..744	CDD:275368	6/20 (30%)
		SFP1	<741..826	CDD:227516	28/88 (32%)
		C2H2 Zn finger	752..772	CDD:275368	6/19 (32%)
		C2H2 Zn finger	780..800	CDD:275368	9/19 (47%)
		C2H2 Zn finger	808..828	CDD:275368	6/20 (30%)
		C2H2 Zn finger	839..859	CDD:275368	8/20 (40%)
		zf-H2C2_2	851..875	CDD:404364	8/24 (33%)
		C2H2 Zn finger	867..887	CDD:275368	7/25 (28%)
		C2H2 Zn finger	895..917	CDD:275370	5/21 (24%)
		C2H2 Zn finger	931..951	CDD:275368	7/20 (35%)
		C2H2 Zn finger	959..979	CDD:275368	6/19 (32%)
		zf-H2C2_2	971..>990	CDD:404364	11/18 (61%)
		C2H2 Zn finger	987..1008	CDD:275368	5/20 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910