DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and Zfp493

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_082678.2	Gene:	Zfp493 / 72958	MGIID:	1920208	Length:	384	Species:	Mus musculus

Alignment Length:	336	Identity:	90/336 - (26%)
Similarity:	140/336 - (41%)	Gaps:	49/336 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   330 CAIC-------NLLVHNFTEMQRHHRLTHQVDPGYMMC--CGRKFTQRKVLAEHVLVHWNPDHFK 385
            |..|       :|||       :|.|: |..:..| :|  ||:.|.....|.:|..:|.....:|
Mouse    83 CKQCGKAFGWKSLLV-------QHQRI-HTGEKPY-ICKECGKAFNYSSTLKQHQRIHTGEKPYK 138

  Fly   386 CSVCEKSFQNSRHLESHQQVHMDPAVKLTFSCDLCSKTFLSKTAIDYHKLNKHVPKSEFKFTCSE 450
            |.||:|:|:.|...:.||::|..   :..:.|::|.|.|...:.:..|   :.:...|..:.|.|
Mouse   139 CEVCDKAFKYSFSFKQHQRIHTG---EKPYKCEVCGKAFNCSSYLGKH---QRIHTGEKPYRCEE 197

  Fly   451 CNKKFLTERKLKNHMSSMHDPESTIICDKCGKQMRTKIILKKHQELMHSDKPRPEPELQQCQICG 515
            |.:.|.....|..| ..:|.......|::|||....:..|.||..:...:||      .:|..||
Mouse   198 CGRAFTNYSGLTVH-RKVHTGVKPYKCEECGKAFSARTTLSKHHRIHTGEKP------YKCDECG 255

  Fly   516 AWLKGMTGLKQHMKSIHVESAGE--HRCHICAKVSPNARALRRHIYHNHECERKFKCTMCEKAFK 578
            ......:...:|.: :|   .||  ::|..|.........|.:| ...|..|:.:||..|.|||.
Mouse   256 KTFSVHSTFSKHQR-LH---TGEKPYKCEECGMAFIGRCILSKH-RGTHTGEKPYKCKECGKAFN 315

  Fly   579 RPQELKEHTSTHTGEVLYTCPNCPMTFFCSANMYKHRQRLHRAQYEADKNQPKPPNILKISR--N 641
            ....|.:|...|.||.|:.|.:|...|.||:.:|||| |:|...        ||....:..:  |
Mouse   316 CSSSLHQHQQIHRGEKLFKCDDCGQAFSCSSYLYKHR-RIHTGM--------KPYKCKECGKAFN 371

  Fly   642 ASTQNKPKQEI 652
            .|:.....|.|
Mouse   372 CSSSRNQHQRI 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856
		C2H2 Zn finger	330..351	CDD:275368	7/27 (26%)
		C2H2 Zn finger	360..378	CDD:275368	6/19 (32%)
		LIM	361..>400	CDD:295319	13/38 (34%)
		C2H2 Zn finger	386..406	CDD:275368	8/19 (42%)
		zf-C2H2_8	389..465	CDD:292531	18/75 (24%)
		C2H2 Zn finger	417..438	CDD:275368	5/20 (25%)
		C2H2 Zn finger	448..465	CDD:275368	5/16 (31%)
		C2H2 Zn finger	477..498	CDD:275368	7/20 (35%)
		C2H2 Zn finger	511..532	CDD:275368	4/20 (20%)
		C2H2 Zn finger	541..562	CDD:275368	4/20 (20%)
		C2H2 Zn finger	570..590	CDD:275368	7/19 (37%)
		C2H2 Zn finger	598..619	CDD:275368	10/20 (50%)
Zfp493	NP_082678.2	KRAB	5..65	CDD:214630
		KRAB	5..44	CDD:279668
		C2H2 Zn finger	83..103	CDD:275368	7/27 (26%)
		zf-H2C2_2	96..120	CDD:290200	10/32 (31%)
		C2H2 Zn finger	111..131	CDD:275368	6/19 (32%)
		zf-H2C2_2	124..148	CDD:290200	9/23 (39%)
		C2H2 Zn finger	139..159	CDD:275368	8/19 (42%)
		zf-H2C2_2	151..176	CDD:290200	7/27 (26%)
		C2H2 Zn finger	167..187	CDD:275368	5/22 (23%)
		zf-H2C2_2	179..204	CDD:290200	6/27 (22%)
		COG5048	<191..327	CDD:227381	37/147 (25%)
		C2H2 Zn finger	195..215	CDD:275368	6/20 (30%)
		zf-H2C2_2	208..231	CDD:290200	7/23 (30%)
		C2H2 Zn finger	223..243	CDD:275368	7/19 (37%)
		zf-H2C2_2	236..259	CDD:290200	8/28 (29%)
		C2H2 Zn finger	251..271	CDD:275368	4/20 (20%)
		C2H2 Zn finger	279..299	CDD:275368	4/20 (20%)
		zf-H2C2_2	292..316	CDD:290200	10/24 (42%)
		C2H2 Zn finger	307..327	CDD:275368	7/19 (37%)
		C2H2 Zn finger	335..355	CDD:275368	10/20 (50%)
		zf-H2C2_2	347..372	CDD:290200	8/33 (24%)
		C2H2 Zn finger	363..383	CDD:275368	4/20 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910