DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and Zfp74

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_848471.2	Gene:	Zfp74 / 72723	MGIID:	107784	Length:	679	Species:	Mus musculus

Alignment Length:	584	Identity:	140/584 - (23%)
Similarity:	207/584 - (35%)	Gaps:	117/584 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 TQENQDQLEGAARRLRKRLKAED-------GSSVDKDKDEDGVEETAEPAPPKKR-RGRPRKSD- 206
            |||...||:...|.|.:.:..|:       |..:.|.:....:|:..||...::. ..||...:
Mouse    18 TQEEWKQLDPTQRNLYRNVMLENYNNLITVGPPLTKPEVIFKLEQEEEPCVVEREVLWRPCPGEI 82

  Fly   207 AAVAPPQKPK-----EDIQLDLKAEELDE------FVDEETDPDFSCLVPSDNSS---EDDGGSD 257
            ..:...||.:     |.|.:..:|.|..|      |.:.::.|....|...|...   |.:.|.|
Mouse    83 LGIDEHQKIQDGQVFEGIVVTSEASECPEEFASTFFPNADSIPSMHSLFECDGVGECLEPNFGDD 147

  Fly   258 GFD---SDSDFELDNGKQEFAVLPKRTVVRPKKYKKRTKPAEPKVRMSR---------------- 303
            ...   .:..||.|:..|.|.......|:.|.|.....|.....:.:.|
Mouse   148 DVQYPLPEEQFEYDDAMQPFHTSSPHFVLTPFKCNHCGKGFSQTLDLIRHLRVHTGGKLYECHQC 212

  Fly   304 --------ELLEQRKKQQEE--YDVIIAKFFTSVLPCAICNLLVHNFTEMQRHHRLTHQVDPGYM 358
                    :|:...|....|  |:            |:.|.......:.:.||.|: |..:..|
Mouse   213 GKGFSHKEKLINHHKLHSREQCYE------------CSECGKTFIKMSNLIRHQRI-HTGEKPY- 263

  Fly   359 MC--CGRKFTQRKVLAEHVLVHWNPDHFKCSVCEKSFQNSRHLESHQQVHMD------------- 408
            :|  ||:.|.|:..|.:|..:|.....:||:.|.|||...:.|.:||:||..
Mouse   264 VCQECGKSFGQKSNLIDHEKIHTGEKPYKCNECGKSFSQKQSLVAHQKVHTGEKPYACNECGKAF 328

  Fly   409 PAV------------KLTFSCDLCSKTFLSKTAIDYHKLNKHVPKSEFKFTCSECNKKFLTERKL 461
            |.|            :..:.||.|.|.|...:.:..|   ..|...|..:.|.||.|.|.....|
Mouse   329 PRVASLALHMRGHTGEKPYKCDKCGKAFSQFSMLIIH---VRVHTGEKPYECGECGKAFSQSSAL 390

  Fly   462 KNHMSSMHDPESTIICDKCGKQMRTKIILKKHQELMHSDKPRPEPELQQCQICGAWLKGMTGLKQ 526
            ..|:.| |..|....|.:|.|....|.....||::...:||      ..|..||.....|:.|.:
Mouse   391 TVHIRS-HTGEKPYECKECRKSFSHKKNFITHQKIHTREKP------YGCNECGKAFIQMSNLVR 448

  Fly   527 HMKSIHVESAGE--HRCHICAKVSPNARALRRHIYHN--HECERKFKCTMCEKAFKRPQELKEHT 587
            |.: ||   .||  :.|..|.|.......|   |.|.  |..|:.::|..|.|||.:.|....|.
Mouse   449 HQR-IH---TGEKPYLCKECGKAFSQKSNL---IAHEKIHSGEKPYECNECGKAFSQKQNFITHQ 506

  Fly   588 STHTGEVLYTCPNCPMTFFCSANMYKH-RQRLHRAQYEADK--NQPKPPNILKISRNASTQNKP 648
            ..||||..|.|..|...|...|::..| |.......||.:|  ......::|.:...:.|..||
Mouse   507 KVHTGEKPYDCNKCGKAFSQIASLTLHLRSHTGEKPYECEKCGKAFSQCSLLNLHMRSHTGEKP 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856	20/95 (21%)
		C2H2 Zn finger	330..351	CDD:275368	5/20 (25%)
		C2H2 Zn finger	360..378	CDD:275368	7/19 (37%)
		LIM	361..>400	CDD:295319	13/38 (34%)
		C2H2 Zn finger	386..406	CDD:275368	8/19 (42%)
		zf-C2H2_8	389..465	CDD:292531	25/100 (25%)
		C2H2 Zn finger	417..438	CDD:275368	6/20 (30%)
		C2H2 Zn finger	448..465	CDD:275368	6/16 (38%)
		C2H2 Zn finger	477..498	CDD:275368	6/20 (30%)
		C2H2 Zn finger	511..532	CDD:275368	6/20 (30%)
		C2H2 Zn finger	541..562	CDD:275368	6/22 (27%)
		C2H2 Zn finger	570..590	CDD:275368	7/19 (37%)
		C2H2 Zn finger	598..619	CDD:275368	6/21 (29%)
Zfp74	NP_848471.2	KRAB	8..68	CDD:214630	13/49 (27%)
		C2H2 Zn finger	181..201	CDD:275368	2/19 (11%)
		COG5048	205..638	CDD:227381	101/397 (25%)
		C2H2 Zn finger	209..229	CDD:275368	2/19 (11%)
		C2H2 Zn finger	237..257	CDD:275368	5/20 (25%)
		C2H2 Zn finger	265..285	CDD:275368	7/19 (37%)
		C2H2 Zn finger	293..313	CDD:275368	8/19 (42%)
		C2H2 Zn finger	321..341	CDD:275368	2/19 (11%)
		C2H2 Zn finger	349..369	CDD:275368	6/22 (27%)
		C2H2 Zn finger	377..397	CDD:275368	8/20 (40%)
		C2H2 Zn finger	405..425	CDD:275368	6/19 (32%)
		C2H2 Zn finger	433..453	CDD:275368	6/20 (30%)
		C2H2 Zn finger	461..481	CDD:275368	6/22 (27%)
		C2H2 Zn finger	489..509	CDD:275368	7/19 (37%)
		C2H2 Zn finger	517..537	CDD:275368	6/19 (32%)
		C2H2 Zn finger	545..565	CDD:275368	2/19 (11%)
		C2H2 Zn finger	573..593	CDD:275368
		C2H2 Zn finger	601..621	CDD:275368
		C2H2 Zn finger	629..649	CDD:275368
		zf-H2C2_2	641..666	CDD:372612
		C2H2 Zn finger	657..677	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910