DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and Prdm5

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_006506667.1	Gene:	Prdm5 / 70779	MGIID:	1918029	Length:	630	Species:	Mus musculus

Alignment Length:	644	Identity:	140/644 - (21%)
Similarity:	229/644 - (35%)	Gaps:	161/644 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 QHFPVQISKESDERICGRCWKIVSDFHTLHEFVSAAQSSLQETKVALMEDDPLTQETTSFPEIIK 104
            :..|..:.:..|.|:   .|::              :.|..|....|...:|.......|  :.:
Mouse    42 KRMPEDLDENMDYRL---MWEV--------------RGSKGEVLYILDATNPRHSNWLRF--VHE 87

  Fly   105 LATQEEEGVTEPQELGGRNFFYPEIKIEEHELDTLPRIEILERSANTQENQDQL-----EGAARR 164
            ..:||.:.:...||  |.|.||  :.:::.|.||...|..|:.....:|.:.|.     ||....
Mouse    88 APSQERKNLAAIQE--GENIFY--LAVDDIETDTELLIGYLDSDVEAEEEEQQALTMTKEGKVDH 148

  Fly   165 LRKRLKAEDGSSVDKDKDEDGVEETAEPAPPKKRRGRPRKSDAAVAPPQ----KPKEDIQLDLKA 225
            .:.:|.|  ||     |...|.||.                   .|.||    .|.|::    ..
Mouse   149 SKGQLAA--GS-----KGHLGCEED-------------------FACPQCESSFPSEEV----LT 183

  Fly   226 EELDEFVDEET-DPDFSC-----------------LVPSDNSSEDDGGSDG--------FDSDSD 264
            |.|.....:.| :.:|.|                 |..:..||..:..|..        |.|...
Mouse   184 EHLQSLHQKPTGEKEFKCENCGKKFPVRQALQRHALFCTARSSLKNSSSSVQCALCNSLFSSALS 248

  Fly   265 FELD----NGKQEFAVLPKRTVVRPKKYKKRTKPAEPKVRMSRELLEQRKKQQEEYDVIIAKFFT 325
            ||..    .|:..|       |.:.....||.|        |::.|.:.::.....|.      .
Mouse   249 FEQHRKACRGEARF-------VCKADSCGKRLK--------SKDALRRHQENVHTGDP------K 292

  Fly   326 SVLPCAICNLLVHNFTEMQRHHRLTHQVDPGYMMC--CGRKFTQRKVLAEHVLVHWNPDHFKCSV 388
            ..|.|::||....:.:.:|.|.:: |::    ..|  |.:||.....|..|::.|.....:.|.:
Mouse   293 RKLICSVCNRKCTSVSSLQEHRKI-HEI----FDCQECMKKFISANQLKRHMITHSEKRPYNCEI 352

  Fly   389 CEKSFQNSRHLESHQQVHMDPAVKLTFSCDLCSKTFLSKTAIDYHK------------------- 434
            |.|||:....:.:|:.:|.:..   .:.|.||.|.|..:.....||
Mouse   353 CNKSFKRLDQVGAHKVIHSEDK---PYQCKLCGKGFAHRNVYKNHKKTHSEERPFQCDACKALFR 414

  Fly   435 ----LNKH--VPKSEFKFTCSECNKKFLTERKLKNHMSSMHDPESTIICDKCGKQMRTKIILKKH 493
                |.:|  :..||..|.|..|:..|..:..|..|:..:|:......|:.|.|...|..:|:.|
Mouse   415 TPFSLQRHLLIHNSERTFKCHHCDATFKRKDTLNVHVQVVHERHKKYRCELCNKAFVTPSVLRSH 479

  Fly   494 QELMHSDKPRPEPELQQCQICGAWLKGMTGLKQHMKSIHVESAGE--HRCHICAKVSPNARALRR 556
            ::....:|.:      .|..||........|:.|::|    ..||  ::|..|.|.......|:.
Mouse   480 KKTHTGEKEK------VCPYCGQKFASSGTLRVHIRS----HTGERPYQCPYCEKGFSKNDGLKM 534

  Fly   557 HIYHNHECERKFKCTMCEKAFKRPQELKEHTSTHTGEVLYTCPNCPMTFFCSANMYKHR 615
            || ..|..|:.::|:.|.|||.:.:.|.||..|||||..:.|..|.:.|.....:.:|:
Mouse   535 HI-RTHTREKPYQCSECSKAFSQKRGLDEHKRTHTGEKPFQCDVCDLAFSLKKMLIRHK 592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071	5/40 (13%)
		FYDLN_acid	<191..268	CDD:302856	18/106 (17%)
		C2H2 Zn finger	330..351	CDD:275368	5/20 (25%)
		C2H2 Zn finger	360..378	CDD:275368	6/19 (32%)
		LIM	361..>400	CDD:295319	11/38 (29%)
		C2H2 Zn finger	386..406	CDD:275368	6/19 (32%)
		zf-C2H2_8	389..465	CDD:292531	22/100 (22%)
		C2H2 Zn finger	417..438	CDD:275368	8/43 (19%)
		C2H2 Zn finger	448..465	CDD:275368	4/16 (25%)
		C2H2 Zn finger	477..498	CDD:275368	6/20 (30%)
		C2H2 Zn finger	511..532	CDD:275368	6/20 (30%)
		C2H2 Zn finger	541..562	CDD:275368	6/20 (30%)
		C2H2 Zn finger	570..590	CDD:275368	8/19 (42%)
		C2H2 Zn finger	598..619	CDD:275368	4/18 (22%)
Prdm5	XP_006506667.1	PR-SET_PRDM5	2..128	CDD:380967	22/108 (20%)
		C2H2 Zn finger	169..190	CDD:275368	6/24 (25%)
		zf-C2H2_8	<172..222	CDD:374215	8/53 (15%)
		C2H2 Zn finger	201..217	CDD:275368	1/15 (7%)
		C2H2 Zn finger	236..256	CDD:275368	4/19 (21%)
		COG5048	258..621	CDD:227381	88/375 (23%)
		C2H2 Zn finger	264..287	CDD:275368	5/30 (17%)
		C2H2 Zn finger	297..317	CDD:275368	5/20 (25%)
		C2H2 Zn finger	322..342	CDD:275368	6/19 (32%)
		C2H2 Zn finger	350..370	CDD:275368	6/19 (32%)
		C2H2 Zn finger	378..398	CDD:275368	7/19 (37%)
		C2H2 Zn finger	406..426	CDD:275368	2/19 (11%)
		C2H2 Zn finger	434..455	CDD:275368	5/20 (25%)
		C2H2 Zn finger	463..483	CDD:275368	6/19 (32%)
		C2H2 Zn finger	491..511	CDD:275368	6/23 (26%)
		C2H2 Zn finger	519..539	CDD:275368	6/20 (30%)
		C2H2 Zn finger	547..567	CDD:275368	8/19 (42%)
		C2H2 Zn finger	575..595	CDD:275368	4/18 (22%)
		C2H2 Zn finger	604..625	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910