DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and Zfp334

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_006235694.1	Gene:	Zfp334 / 685574	RGDID:	1592574	Length:	678	Species:	Rattus norvegicus

Alignment Length:	646	Identity:	154/646 - (23%)
Similarity:	219/646 - (33%)	Gaps:	170/646 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 TQETTSFPEIIKLATQEEEGVTEPQELG-GRNFFYPEIKIEEH-----------ELDTLPRIE-- 143
            ||.:.||.::....|:||.     |.|| .:...|.::.:|.:           :.|.:.::|
  Rat     4 TQTSVSFKDLTVDFTREEW-----QYLGPAQRLLYRDVMLENYSNLIALGFRVSKPDVILKLEQG 63

  Fly   144 ----ILE----RSANTQENQDQLEGAARRLRKRLK---------------------AEDGSSVDK 179
                |:|    ::.:...:.|.||...|...|.||                     |.|.:||..
  Rat    64 EEPWIVEDLSHQNLSHAGDDDALEKDKRTQDKHLKQLLVINNKTTSEKANLFEKTVALDTNSVSS 128

  Fly   180 -------DKDEDGVEETAEPAPPKKRRGRPRKSDAAVAPPQKPKEDIQLDLKAEELDEFVDEETD 237
                   |...:|::..:|....|     |.|::..||.....:....|..||           |
  Rat   129 GKMLHKYDPGGNGLKNNSEDTVIK-----PSKANGKVAAEHDGRGKPALHTKA-----------D 177

  Fly   238 PDFSCLVPSDNSSEDDGGSDGFDSDSDF---------ELDNGKQEFAVLPKRTVVRPKKYKKRTK 293
            ...|.......|...|..|.|.|.....         |.:.|:||.|.               ||
  Rat   178 RSHSAAKRIKWSEVGDVRSQGEDLTQQLNNQAVSQPSEHNEGEQESAC---------------TK 227

  Fly   294 PAEPKVRMSRELLEQRKKQQEEYDVII-AKFFTSVLPCAICNLLVHNF---TEMQRH-------- 346
              |...|...|..|.||...:...:|: .:..|...|.| ||.....|   ..:.||
  Rat   228 --ECPERKRNECAECRKTFSKRSTLIVHLRIHTGERPYA-CNYCRKTFRIKASLTRHQRIHTGER 289

  Fly   347 -------------------HRLTHQVDPGYMMC--CGRKFTQRKVLAEHVLVHWNPDHFKCSVCE 390
                               |:..|..:..| .|  ||:.|.::..||||...|.....:||..|.
  Rat   290 PYKCKECGKAFIDKSALIVHQRIHGGEKSY-ECIECGKTFFRKSALAEHFRSHTGEKPYKCKECG 353

  Fly   391 KSFQNSRHLESHQQVHMDPAVKLTFSCDLCSKTFLSKTAIDYHKLNKHVPKSEFKFTCSECNKKF 455
            .:|....:|..||:.|......   .|..|.|||...:|:..|   :.:...|..:.|.||:|.|
  Rat   354 NAFGKKSYLIVHQRTHRGEKPN---ECKECGKTFFCLSALTAH---QRIHTGEKPYECKECDKTF 412

  Fly   456 LTERKLKNHMSSMHDPESTIICDKCGKQMRTKIILKKHQELMHSDKPRPEPELQQCQICGA--WL 518
            ..:..|..|:.| |..|....|.:|||.:.||..|..|| ::|..|...|     |..||.  :|
  Rat   413 FCQSALNVHLRS-HTGEKPYKCRQCGKFLCTKSALVAHQ-VIHRGKKSFE-----CGECGKLFYL 470

  Fly   519 KGMTGLKQ--HMKSIH-------VESAGEHRC------------HICAKVSPNARALRRHIYHNH 562
            |....:.|  |....|       ..|.|:..|            |.|......|....|.:.|..
  Rat   471 KSTLTIHQRTHTGEKHGVLSKWSRPSTGKSNCGEQKRVEAKENLHECHDHKRTAHKSSRRVAHKR 535

  Fly   563 EC-ERKFKCTMCEKAFKRPQELKEHTSTHTGEVLYTCPNCPMTFFCSANMYKHRQRLHRAQ 622
            .. ||.::|..|.:.:.|...|:.|..|||||..|.|..|..| ||....:...||.|..:
  Rat   536 TIWERPYECQECGRTYCRKSALRHHQKTHTGERPYECKECGKT-FCQKVSFTEHQRTHTGE 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856	17/85 (20%)
		C2H2 Zn finger	330..351	CDD:275368	7/50 (14%)
		C2H2 Zn finger	360..378	CDD:275368	8/19 (42%)
		LIM	361..>400	CDD:295319	12/38 (32%)
		C2H2 Zn finger	386..406	CDD:275368	6/19 (32%)
		zf-C2H2_8	389..465	CDD:292531	20/75 (27%)
		C2H2 Zn finger	417..438	CDD:275368	7/20 (35%)
		C2H2 Zn finger	448..465	CDD:275368	6/16 (38%)
		C2H2 Zn finger	477..498	CDD:275368	9/20 (45%)
		C2H2 Zn finger	511..532	CDD:275368	7/24 (29%)
		C2H2 Zn finger	541..562	CDD:275368	6/32 (19%)
		C2H2 Zn finger	570..590	CDD:275368	5/19 (26%)
		C2H2 Zn finger	598..619	CDD:275368	7/20 (35%)
Zfp334	XP_006235694.1	KRAB	8..68	CDD:214630	12/64 (19%)
		KRAB	8..47	CDD:279668	10/43 (23%)
		C2H2 Zn finger	237..257	CDD:275368	4/19 (21%)
		COG5048	261..677	CDD:227381	94/351 (27%)
		C2H2 Zn finger	265..285	CDD:275368	5/19 (26%)
		zf-H2C2_2	277..300	CDD:290200	2/22 (9%)
		C2H2 Zn finger	293..313	CDD:275368	1/19 (5%)
		C2H2 Zn finger	321..341	CDD:275368	8/19 (42%)
		zf-H2C2_2	333..356	CDD:290200	8/22 (36%)
		C2H2 Zn finger	349..369	CDD:275368	6/19 (32%)
		C2H2 Zn finger	377..397	CDD:275368	7/22 (32%)
		zf-H2C2_2	389..412	CDD:290200	7/25 (28%)
		C2H2 Zn finger	405..425	CDD:275368	8/20 (40%)
		zf-H2C2_2	417..438	CDD:290200	7/21 (33%)
		C2H2 Zn finger	433..453	CDD:275368	9/20 (45%)
		C2H2 Zn finger	461..481	CDD:275368	6/19 (32%)
		C2H2 Zn finger	544..564	CDD:275368	5/19 (26%)
		zf-H2C2_2	556..579	CDD:290200	11/23 (48%)
		C2H2 Zn finger	572..592	CDD:275368	7/20 (35%)
		zf-H2C2_2	584..609	CDD:290200	3/12 (25%)
		C2H2 Zn finger	600..620	CDD:275368
		C2H2 Zn finger	628..648	CDD:275368
		zf-H2C2_2	641..665	CDD:290200
		C2H2 Zn finger	656..676	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910