DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and Zscan2

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_006229527.2	Gene:	Zscan2 / 683603	RGDID:	1584548	Length:	614	Species:	Rattus norvegicus

Alignment Length:	666	Identity:	157/666 - (23%)
Similarity:	239/666 - (35%)	Gaps:	186/666 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 EVTTIVNQHFPV-QISKESDERICGRCWKIVSDFHTLHEFVSAAQSSLQETKVALMEDDPLTQET 96
            ||..:.....|: |:.:|.||:         ::..|:   :....|.:||  ..|.||.|   |:
  Rat     4 EVPAVSTPLSPLAQVPQEXDEQ---------AEVTTM---ILEDDSWVQE--AVLQEDGP---ES 51

  Fly    97 TSFPEIIKLATQEEEGVTEP--------QELGGRNFFYPEIKIEEHELDTLPRIEILERSANTQE 153
            ..||:.....:.:|||..|.        :|| .|.:..||:..:|..|..|||    |..|..||
  Rat    52 EPFPQSTGKGSPQEEGTAEGPRGALVRFREL-CRRWLRPEVHTKEQMLTVLPR----EIQAWLQE 111

  Fly   154 NQDQLEGAARRLRKRLKAEDGSSVDKDKDEDGVEETAEPAPPKKRRGRPRKSDAAVAPPQK---- 214
            :                                              ||..|:.|||..:.
  Rat   112 H----------------------------------------------RPESSEEAVALVEDLTQT 130

  Fly   215 -PKEDIQLDLKAEE---LDEFVDEETDPDFSCLVPSDNSSEDDGGSDGFDSDSDFELDNGK---- 271
             |..|.::..:..|   .|.|.|.|:...|..:...:...:.||       :||||.|.|.
  Rat   131 FPHNDFEIQSENGENSNQDVFEDVESHETFLKIPGGEGGQQSDG-------ESDFERDCGSGGAQ 188

  Fly   272 -----QEFAVLPKRTVVRPKKYKKRTKPAEPKVRMSREL-----LEQRKKQQEEYDVIIAKFFTS 326
                 :|...||..                     .||:     |:.....::.|:
  Rat   189 GNVPGEEHRDLPSE---------------------GREVGQLIGLQGTYLGEKPYE--------- 223

  Fly   327 VLPCAICNLLVHNFTEMQRHHRLTHQ---VDPGYMMC--CGRKFTQRKVLAEHVLVHWNPDHFKC 386
               |..|..     |..::.|.:||:   ....|..|  ||:.|:.....:.|...|.....:||
  Rat   224 ---CPQCGK-----TFSRKSHLITHERTHTGEKYYKCEECGKSFSDGSNFSRHQTTHTGEKPYKC 280

  Fly   387 SVCEKSFQNSRHLESHQQVHMDPAVKLTFSCDLCSKTFLSKTAIDYHKLNKHVPKSEFKFTCSEC 451
            ..|.|||..|.:|.:||::|..   :..|.|..|.|:|.....:..|: ..|.  .|..::|.||
  Rat   281 RDCGKSFSRSANLITHQRIHTG---EKPFQCAECGKSFSRSPNLIAHQ-RTHT--GEKPYSCPEC 339

  Fly   452 NKKFLTERKLKNHMSSMHDPESTIICDKCGKQMRTKIILKKHQELMHSDKPRPEPELQQCQICGA 516
            .|.|.....|..| ..:|..|....|.:||:.......|.:||.:...:||      .:|..||.
  Rat   340 GKSFGNRSSLNTH-QGIHTGEKPYACKECGESFSYNSNLIRHQRIHTGEKP------YKCTECGQ 397

  Fly   517 WLKGMTGLKQHMKSIHVESAGE--HRCHICAKVSPNARALRRHIYHNHECERKFKCTMCEKAFKR 579
            .....:.|..|.::    ..||  ::|..|.|....:..|..| ...|..|:.:||.:|.|:|.:
  Rat   398 KFSQSSALITHRRT----HTGEKPYQCSECGKSFSRSSNLATH-RRTHLVEKPYKCGVCGKSFSQ 457

  Fly   580 PQELKEHTSTHTGEVLYTCPNCPMTFFCSANMYKHRQRLHRAQ--YE--------ADKNQPKPPN 634
            ...|..|...||||..|.|..|..:|..|:|:.|| ||:|..:  |:        :.::|
  Rat   458 SSSLIAHQGMHTGEKPYECLTCGESFSWSSNLIKH-QRIHTGEKPYKCGDCGKCFSQRSQ----- 516

  Fly   635 ILKISRNASTQNKPKQ 650
             |.:.:...|..||.|
  Rat   517 -LVVHQRTHTGEKPYQ 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071	9/48 (19%)
		FYDLN_acid	<191..268	CDD:302856	20/84 (24%)
		C2H2 Zn finger	330..351	CDD:275368	4/20 (20%)
		C2H2 Zn finger	360..378	CDD:275368	5/19 (26%)
		LIM	361..>400	CDD:295319	12/38 (32%)
		C2H2 Zn finger	386..406	CDD:275368	9/19 (47%)
		zf-C2H2_8	389..465	CDD:292531	23/75 (31%)
		C2H2 Zn finger	417..438	CDD:275368	5/20 (25%)
		C2H2 Zn finger	448..465	CDD:275368	6/16 (38%)
		C2H2 Zn finger	477..498	CDD:275368	6/20 (30%)
		C2H2 Zn finger	511..532	CDD:275368	5/20 (25%)
		C2H2 Zn finger	541..562	CDD:275368	5/20 (25%)
		C2H2 Zn finger	570..590	CDD:275368	6/19 (32%)
		C2H2 Zn finger	598..619	CDD:275368	9/20 (45%)
Zscan2	XP_006229527.2	SCAN	69..131	CDD:396558	21/112 (19%)
		COG5048	220..600	CDD:227381	93/354 (26%)
		C2H2 Zn finger	224..244	CDD:275368	6/24 (25%)
		C2H2 Zn finger	252..272	CDD:275368	5/19 (26%)
		C2H2 Zn finger	280..300	CDD:275368	9/19 (47%)
		C2H2 Zn finger	308..328	CDD:275368	5/20 (25%)
		C2H2 Zn finger	336..356	CDD:275368	7/20 (35%)
		C2H2 Zn finger	364..384	CDD:275368	6/19 (32%)
		C2H2 Zn finger	392..412	CDD:275368	5/23 (22%)
		C2H2 Zn finger	420..440	CDD:275368	5/20 (25%)
		C2H2 Zn finger	448..468	CDD:275368	6/19 (32%)
		C2H2 Zn finger	476..496	CDD:275368	9/20 (45%)
		C2H2 Zn finger	504..524	CDD:275368	2/25 (8%)
		C2H2 Zn finger	532..552	CDD:275368	157/666 (24%)
		C2H2 Zn finger	560..580	CDD:275368
		C2H2 Zn finger	588..608	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910