DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and BC024063

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_001360962.1	Gene:	BC024063 / 666584	MGIID:	2670978	Length:	749	Species:	Mus musculus

Alignment Length:	324	Identity:	92/324 - (28%)
Similarity:	135/324 - (41%)	Gaps:	29/324 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   333 CNLLVHNFTEMQRHHRLTHQVDPGYMMC--CGRKFTQRKVLAEHVLVHWNPDHFKCSVCEKSFQN 395
            |:..:.|...:::|.| :|.....| .|  ||:.|..|..|..|...|.....:.|:.|.|:|..
Mouse   111 CSKPIANSNSLRQHER-SHSRRKLY-ECNYCGKAFPSRSSLQVHERTHTGEKPYGCNECGKAFST 173

  Fly   396 SRHLESHQQVHMDPAVKLTFSCDLCSKTFLSKTAIDYHKLNKHVPKSEFKFTCSECNKKFLTERK 460
            ..||:.||:.|..   :..:.|..|.|.|.||..:..|: ..|.  .|..:.|.||.|.|.|...
Mouse   174 RSHLQIHQRTHTG---EKPYGCSECGKAFASKGNLQTHQ-RTHT--GEKPYCCHECGKAFATHNN 232

  Fly   461 LKNHMSSMHDPESTIICDKCGKQMRTKIILKKHQELMHSDKPRPEPELQQCQICGAWLKGMTGLK 525
            |:.| ..:|..|....|::||:.......|:.|::....:||      .:|..|.........|:
Mouse   233 LQIH-EIIHTGEKPYECNECGRAFAYSRALEAHEKTHTGEKP------YECNQCSKAFASHASLR 290

  Fly   526 QHMKSIHVESAGE--HRCHICAKVSPNARALRRHIYHNHECERKFKCTMCEKAFKRPQELKEHTS 588
            .|:|    ...||  ..|..|.|...:...|.|| ...|..|:.::|:.|.|||.....|:.|..
Mouse   291 NHLK----HHTGEKFFVCTQCGKAFTSQSILHRH-ERTHTGEKPYECSQCGKAFALQSYLQIHKR 350

  Fly   589 THTGEVLYTCPNCPMTFFCSANMYKHRQRLHRAQYEADKNQPKPPNI----LKISRNASTQNKP 648
            |||||..|.|.:|...|...||:..| ::.|..:.....||.....:    |:|...:.|.|||
Mouse   351 THTGEKPYECNHCGKAFTSHANLQNH-EKHHTGEKPYGCNQCGKAFVCSSSLQIHERSHTGNKP 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856
		C2H2 Zn finger	330..351	CDD:275368	4/17 (24%)
		C2H2 Zn finger	360..378	CDD:275368	7/19 (37%)
		LIM	361..>400	CDD:295319	12/38 (32%)
		C2H2 Zn finger	386..406	CDD:275368	8/19 (42%)
		zf-C2H2_8	389..465	CDD:292531	24/75 (32%)
		C2H2 Zn finger	417..438	CDD:275368	7/20 (35%)
		C2H2 Zn finger	448..465	CDD:275368	7/16 (44%)
		C2H2 Zn finger	477..498	CDD:275368	5/20 (25%)
		C2H2 Zn finger	511..532	CDD:275368	5/20 (25%)
		C2H2 Zn finger	541..562	CDD:275368	6/20 (30%)
		C2H2 Zn finger	570..590	CDD:275368	7/19 (37%)
		C2H2 Zn finger	598..619	CDD:275368	6/20 (30%)
BC024063	NP_001360962.1	KRAB	4..44	CDD:366587
		C2H2 Zn finger	109..128	CDD:275368	4/17 (24%)
		COG5048	132..489	CDD:227381	87/302 (29%)
		C2H2 Zn finger	136..156	CDD:275368	7/19 (37%)
		C2H2 Zn finger	164..184	CDD:275368	8/19 (42%)
		C2H2 Zn finger	192..212	CDD:275368	7/20 (35%)
		C2H2 Zn finger	220..240	CDD:275368	8/20 (40%)
		C2H2 Zn finger	248..268	CDD:275368	5/19 (26%)
		C2H2 Zn finger	276..296	CDD:275368	5/23 (22%)
		C2H2 Zn finger	304..324	CDD:275368	6/20 (30%)
		COG5048	312..736	CDD:227381	33/104 (32%)
		C2H2 Zn finger	332..352	CDD:275368	7/19 (37%)
		C2H2 Zn finger	360..380	CDD:275368	6/20 (30%)
		C2H2 Zn finger	388..408	CDD:275368	4/19 (21%)
		C2H2 Zn finger	416..436	CDD:275368
		C2H2 Zn finger	444..464	CDD:275368
		C2H2 Zn finger	472..492	CDD:275368
		C2H2 Zn finger	500..520	CDD:275368
		C2H2 Zn finger	528..548	CDD:275368
		C2H2 Zn finger	556..576	CDD:275368
		C2H2 Zn finger	584..604	CDD:275368
		C2H2 Zn finger	612..632	CDD:275368
		C2H2 Zn finger	640..660	CDD:275368
		C2H2 Zn finger	668..688	CDD:275368
		C2H2 Zn finger	696..716	CDD:275368
		C2H2 Zn finger	724..744	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910