DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and ZNF732

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_001131080.1	Gene:	ZNF732 / 654254	HGNCID:	37138	Length:	585	Species:	Homo sapiens

Alignment Length:	321	Identity:	94/321 - (29%)
Similarity:	135/321 - (42%)	Gaps:	34/321 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   315 EYDVIIA--KFFTSVLPCAICNLLVHNFTEMQRHHRLTHQVDPGYMM-CCGRKFTQRKVLAEHVL 376
            ||::|..  |.||    |..|..:....:...:|.  .|..:..|.. .||:.|.:...|.:|..
Human   212 EYEIIHTGEKPFT----CEECGNIFTTSSNFAKHK--VHTGEKSYKYEECGKAFNRSSTLTKHKR 270

  Fly   377 VHWNPDHFKCSVCEKSFQNSRHLESHQQVHMDPAVKLTFSCDLCSKTFLSKTAIDYHKLNKHVPK 441
            :|.....|.|..|.|...:|.::..|:::|....:   :.|..|.|.|...|.:..|   ..:..
Human   271 IHAEEKPFTCEECGKIITSSSNVAKHKKIHTGEKL---YKCQECGKVFNRSTTLTKH---NRIHT 329

  Fly   442 SEFKFTCSECNKKFLTERKLKNHMSSMHDPESTIICDKCGKQMRTKIILKKHQELMHSDKPRPEP 506
            .|..:||.||.|.|.....|..| ..:|..|....|::|||..|....|.||:.:...:||
Human   330 GEKPYTCEECGKAFSRSSVLNEH-KRIHTGEKPYKCEQCGKAFRQSATLNKHKSIHTGEKP---- 389

  Fly   507 ELQQCQICGAWLKGMTGLKQHMKSIHVESAGE--HRCHICAKVSPNARALRRH-IYHNHECERKF 568
              ..|:.||......|.|.:| |.||   .||  |:|..|.|....:..|.:| |.|..  |:.:
Human   390 --YTCEECGKAFSRFTTLNEH-KRIH---TGERPHKCEECGKAFGWSTDLNKHKIIHTG--EKPY 446

  Fly   569 KCTMCEKAFKRPQELKEHTSTHTGEVLYTCPNCPMTFFCSANMYKHRQRLHRAQ--YEADK 627
            ||..|.|||.....|.:|...||||..|.|..|...|.||..:.||: .:|..:  ||.::
Human   447 KCEECGKAFGWSAYLSKHKKIHTGEKPYRCEECGKAFLCSRALNKHK-TIHTGEKPYECEE 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856
		C2H2 Zn finger	330..351	CDD:275368	3/20 (15%)
		C2H2 Zn finger	360..378	CDD:275368	5/17 (29%)
		LIM	361..>400	CDD:295319	11/38 (29%)
		C2H2 Zn finger	386..406	CDD:275368	5/19 (26%)
		zf-C2H2_8	389..465	CDD:292531	19/75 (25%)
		C2H2 Zn finger	417..438	CDD:275368	6/20 (30%)
		C2H2 Zn finger	448..465	CDD:275368	6/16 (38%)
		C2H2 Zn finger	477..498	CDD:275368	8/20 (40%)
		C2H2 Zn finger	511..532	CDD:275368	7/20 (35%)
		C2H2 Zn finger	541..562	CDD:275368	7/21 (33%)
		C2H2 Zn finger	570..590	CDD:275368	7/19 (37%)
		C2H2 Zn finger	598..619	CDD:275368	7/20 (35%)
ZNF732	NP_001131080.1	KRAB	4..62	CDD:214630
		KRAB	4..43	CDD:279668
		COG5048	130..542	CDD:227381	94/321 (29%)
		C2H2 Zn finger	143..163	CDD:275368
		C2H2 Zn finger	170..189	CDD:275368
		C2H2 Zn finger	225..244	CDD:275368	3/20 (15%)
		C2H2 Zn finger	253..272	CDD:275368	5/18 (28%)
		C2H2 Zn finger	280..300	CDD:275368	5/19 (26%)
		zf-H2C2_2	292..317	CDD:290200	6/27 (22%)
		C2H2 Zn finger	308..328	CDD:275368	6/22 (27%)
		zf-H2C2_2	321..345	CDD:290200	8/26 (31%)
		C2H2 Zn finger	336..356	CDD:275368	7/20 (35%)
		zf-H2C2_2	349..373	CDD:290200	8/24 (33%)
		C2H2 Zn finger	364..384	CDD:275368	8/19 (42%)
		zf-H2C2_2	377..401	CDD:290200	8/29 (28%)
		C2H2 Zn finger	392..412	CDD:275368	7/20 (35%)
		zf-H2C2_2	405..427	CDD:290200	11/25 (44%)
		C2H2 Zn finger	420..440	CDD:275368	6/19 (32%)
		zf-H2C2_2	432..455	CDD:290200	9/24 (38%)
		C2H2 Zn finger	448..468	CDD:275368	7/19 (37%)
		zf-H2C2_2	460..483	CDD:290200	9/22 (41%)
		C2H2 Zn finger	476..496	CDD:275368	7/20 (35%)
		zf-H2C2_2	488..511	CDD:290200	5/20 (25%)
		C2H2 Zn finger	504..524	CDD:275368	0/3 (0%)
		zf-H2C2_2	516..541	CDD:290200
		C2H2 Zn finger	532..552	CDD:275368
		C2H2 Zn finger	560..579	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910