DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and PRDM15

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_011527985.1	Gene:	PRDM15 / 63977	HGNCID:	13999	Length:	1441	Species:	Homo sapiens

Alignment Length:	781	Identity:	162/781 - (20%)
Similarity:	282/781 - (36%)	Gaps:	226/781 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 AMMGDYIDVHSARGDQLEVTTIVNQHFPV-QISKESDERI----CGRCWKIVSDFHTLHEFVSAA 75
            |.|..::: |||.|.:   .....:..|| :::::..|.|    |..|    |.:|
Human   274 ASMHTFLN-HSATGIR---EAGCRKDMPVSEMAEDGSEEIMFIWCEDC----SQYH--------- 321

  Fly    76 QSSLQETKVALMEDDP--LTQETTSFPEIIKLATQEE--EGVTEPQELGGRNFFYP--EIKIEEH 134
            .|...|....:|..|.  |::..:|.|..:::...|:  |||....:|..|..|.|  ..::.:.
Human   322 DSECPELGPVVMVKDSFVLSRARSSLPPNLEIRRLEDGAEGVFAITQLVKRTQFGPFESRRVAKW 386

  Fly   135 ELDTLPRIEILERSAN----TQENQDQ------LEGAARRLRKRLKA-EDGSSVDKDKDEDGVEE 188
            |.::...:::.::..:    ...|:|.      :..||....:.|.| :.||.|        ...
Human   387 EKESAFPLKVFQKDGHPVCFDTSNEDDCNWMMLVRPAAEAEHQNLTAYQHGSDV--------YFT 443

  Fly   189 TAEPAPP------------KKRRGRPRKSDA-----AVAPPQK--PKED--------------IQ 220
            |:...||            .|:..:|....|     |...|:.  |.|.              ::
Human   444 TSRDIPPGTELRVWYAAFYAKKMDKPMLKQAGSGVHAAGTPENSAPVESEPSQWACKVCSATFLE 508

  Fly   221 LDLKAEELDEFVDEETDPDFSCLVPSDNSSEDDGGSDGFDSDSDFELDNGKQEFAVLPKRTVVRP 285
            |.|..|.|...:::.     ..|.|         ||....:..:.|.|..:.|...:|:...|..
Human   509 LQLLNEHLLGHLEQA-----KSLPP---------GSQSEAAAPEKEQDTPRGEPPAVPESENVAT 559

  Fly   286 KKYKKRTKPA-EPKVRMSRE--LLEQRKKQQEEYDVIIAKFFTSVLPC-------------AICN 334
            |:.||:.:.. :|||..:.:  ::.:.|:..|:    :|:..|.|.|.             .:..
Human   560 KEQKKKPRRGRKPKVSKAEQPLVIVEDKEPTEQ----VAEIITEVPPDEPVSATPDERIMELVLG 620

  Fly   335 LLVHNFTEMQRHHRLTHQVD-----PGYMMCCGRKFTQRKV---LAEHVLVHWNPDHFKCSVCEK 391
            .|....|:.....:.||..:     ...::...|...:||:   |.||..|      ::|::|.|
Human   621 KLATTTTDTSSVPKFTHHQNNTITLKRSLILSSRHGIRRKLIKQLGEHKRV------YQCNICSK 679

  Fly   392 SFQNSRHLESHQQVHMDPAVKLTFSCDLCSKTFLSKTAIDYHKLNKHVPK---SEFKFTCSECNK 453
            .||||.:|..|.:.|.|   || |.|:.|:|.|..|.::..|...||...   .|:::.|..|.|
Human   680 IFQNSSNLSRHVRSHGD---KL-FKCEECAKLFSRKESLKQHVSYKHSRNEVDGEYRYRCGTCEK 740

  Fly   454 KFLTERKLKNHMSSMHDPESTIICDKCGKQMRTKIILKKHQELMHSDKPRPEPELQQCQICGAWL 518
            .|..|..|:.|  :....:.|..|:.|.:...|...|.||:: .|.||.      ..|::|....
Human   741 TFRIESALEFH--NCRTDDKTFQCEMCFRFFSTNSNLSKHKK-KHGDKK------FACEVCSKMF 796

  Fly   519 -----------KGMTGLKQHMKSIHVESAGEH---------RCHICAKVSPNARALRRHIY-HNH 562
                       :.:.|::: :|...:|:.||:         .|.:|.||......:.:|:. |.
Human   797 YRKDVMLDHQRRHLEGVRR-VKREDLEAGGENLVRYKKEPSGCPVCGKVFSCRSNMNKHLLTHG- 859

  Fly   563 ECERKFKCTMCEKAFKRPQELKEHTSTHTGEVL-------------------------------- 595
              ::|:.|.:|.:.|.|...|::|...|..::.
Human   860 --DKKYTCEICGRKFFRVDVLRDHIHVHFKDIALMDDHQREEFIGKIGISSEENDDNSDESADSE 922

  Fly   596 ---YTCPNCPMTFFCSANMYKHRQRLH----------------RAQYEAD-----KNQPKPPNIL 636
               |:|..|.:||.......||...:|                :|.|.|.     :|.| .||:.
Human   923 PHKYSCKRCQLTFGRGKEYLKHIMEVHKEKGYGCSICNRRFALKATYHAHMVIHRENLP-DPNVQ 986

  Fly   637 K 637
            |
Human   987 K 987

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071	15/69 (22%)
		FYDLN_acid	<191..268	CDD:302856	18/109 (17%)
		C2H2 Zn finger	330..351	CDD:275368	2/33 (6%)
		C2H2 Zn finger	360..378	CDD:275368	6/20 (30%)
		LIM	361..>400	CDD:295319	14/41 (34%)
		C2H2 Zn finger	386..406	CDD:275368	9/19 (47%)
		zf-C2H2_8	389..465	CDD:292531	28/78 (36%)
		C2H2 Zn finger	417..438	CDD:275368	6/20 (30%)
		C2H2 Zn finger	448..465	CDD:275368	6/16 (38%)
		C2H2 Zn finger	477..498	CDD:275368	6/20 (30%)
		C2H2 Zn finger	511..532	CDD:275368	4/31 (13%)
		C2H2 Zn finger	541..562	CDD:275368	6/21 (29%)
		C2H2 Zn finger	570..590	CDD:275368	6/19 (32%)
		C2H2 Zn finger	598..619	CDD:275368	6/20 (30%)
PRDM15	XP_011527985.1	SET	349..465	CDD:214614	21/123 (17%)
		GAGA_bind	<515..>580	CDD:283799	16/78 (21%)
		COG5048	663..1125	CDD:227381	81/349 (23%)
		zf-C2H2	672..694	CDD:278523	9/21 (43%)
		C2H2 Zn finger	674..694	CDD:275368	9/19 (47%)
		C2H2 Zn finger	701..722	CDD:275368	6/20 (30%)
		C2H2 Zn finger	735..751	CDD:275368	6/15 (40%)
		C2H2 Zn finger	789..809	CDD:275368	2/19 (11%)
		C2H2 Zn finger	838..858	CDD:275368	5/19 (26%)
		C2H2 Zn finger	865..885	CDD:275368	6/19 (32%)
		C2H2 Zn finger	928..949	CDD:275370	6/20 (30%)
		C2H2 Zn finger	956..976	CDD:275368	3/19 (16%)
		C2H2 Zn finger	992..1012	CDD:275368
		zf-H2C2_2	1004..1029	CDD:290200
		C2H2 Zn finger	1020..1040	CDD:275368
		C2H2 Zn finger	1048..1068	CDD:275368
		zf-H2C2_2	1060..1085	CDD:290200
		C2H2 Zn finger	1076..1096	CDD:275368
		C2H2 Zn finger	1104..1124	CDD:275368
		C2H2 Zn finger	1132..1153	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000