DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and ZNF335

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_071378.1	Gene:	ZNF335 / 63925	HGNCID:	15807	Length:	1342	Species:	Homo sapiens

Alignment Length:	571	Identity:	119/571 - (20%)
Similarity:	190/571 - (33%)	Gaps:	189/571 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 TQEEEGVTEPQELGGRNFFYPEIKIEEHELDTLP--RIEILERSANTQENQDQLEGAARRLRKRL 169
            :|||||              ||   ||.:.|.:.  .|:.||..::....:|:..|...||::
Human   294 SQEEEG--------------PE---EEDDDDIVDAGAIDDLEEDSDYNPAEDEPRGRQLRLQR-- 339

  Fly   170 KAEDGSSVDKDKDEDGVEETAEPAP----PKKRRGRPRKSDAAVAPPQKPKEDIQLDLKAEELDE 230
                                  |.|    |::|.|||||.      |:....|:...::.|.|..
Human   340 ----------------------PTPSTPRPRRRPGRPRKL------PRLEISDLPDGVEGEPLVS 376

  Fly   231 FVDEETDPDFSCLVPSDNSSEDDGGSDGF----------------DSDSDFELDNGKQEFAVLPK 279
            ....::.|:     |.|..:....|....                .||::....:...|...||:
Human   377 SQSGQSPPE-----PQDPEAPSSSGPGHLVAMGKVSRTPVEAGVSQSDAENAAPSCPDEHDTLPR 436

  Fly   280 RTVVRPKKYKKRTKPAEPKVRMSRELLEQRKKQQEEYDVIIAKFFTSVLP------CAIC--NLL 336
            |          |.:|       ||..|   .|:..:|      ::.|..|      |.||  ..|
Human   437 R----------RGRP-------SRRFL---GKKYRKY------YYKSPKPLLRPFLCRICGSRFL 475

  Fly   337 VHNFTEMQRHHRLTHQV-DPGYMMC--CGRKFTQRKVLAEHVLVHWNPDHFKCSVCEKSFQNSRH 398
            .|   |..|.|..:|:. ||....|  |..:..:...|.||:..|.....:||..|..:....:.
Human   476 SH---EDLRFHVNSHEAGDPQLFKCLQCSYRSRRWSSLKEHMFNHVGSKPYKCDECSYTSVYRKD 537

  Fly   399 LESHQQVHM-------DPAVKLTFSCDLCSKTFLSKTAIDYHKLNKHVPKSEFKFTCSECNKKFL 456
            :..|..||.       ||..||:                              .|.|..|.:.:.
Human   538 VIRHAAVHSRDRKKRPDPTPKLS------------------------------SFPCPVCGRVYP 572

  Fly   457 TERKLKNHMSSMHDPESTIICDKCGKQMRTKIILKKHQELMHSDKPRPEPELQQCQICGAWLKGM 521
            .:::|..||.: |..|...:||||||..:.:...|.|
Human   573 MQKRLTQHMKT-HSTEKPHMCDKCGKSFKKRYTFKMH---------------------------- 608

  Fly   522 TGLKQHMKSIHVESAGEHRCHICAKVSPNARALRRHIYHNHECERKFKCTMCEKAFKRPQELKEH 586
              |..|::::   :....:|..|..|..:.:||..| ..:|..::.|||:.|.....|...|..|
Human   609 --LLTHIQAV---ANRRFKCEFCEFVCEDKKALLNH-QLSHVSDKPFKCSFCPYRTFREDFLLSH 667

  Fly   587 TST-HTGEVLYTCPNCPMTFFCSANMYKHRQRLHRAQYE--ADKNQPKPPN 634
            .:. |||...:.|..|..:.....|:..|.:..|.:.:|  ..::..:||:
Human   668 VAVKHTGAKPFACEYCHFSTRHKKNLRLHVRCRHASSFEEWGRRHPEEPPS 718

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856	19/96 (20%)
		C2H2 Zn finger	330..351	CDD:275368	8/22 (36%)
		C2H2 Zn finger	360..378	CDD:275368	5/19 (26%)
		LIM	361..>400	CDD:295319	8/38 (21%)
		C2H2 Zn finger	386..406	CDD:275368	3/19 (16%)
		zf-C2H2_8	389..465	CDD:292531	12/82 (15%)
		C2H2 Zn finger	417..438	CDD:275368	0/20 (0%)
		C2H2 Zn finger	448..465	CDD:275368	3/16 (19%)
		C2H2 Zn finger	477..498	CDD:275368	8/20 (40%)
		C2H2 Zn finger	511..532	CDD:275368	2/20 (10%)
		C2H2 Zn finger	541..562	CDD:275368	6/20 (30%)
		C2H2 Zn finger	570..590	CDD:275368	5/20 (25%)
		C2H2 Zn finger	598..619	CDD:275368	4/20 (20%)
ZNF335	NP_071378.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..102
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	201..228
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	274..442		42/216 (19%)
		C2H2 Zn finger	467..487	CDD:275368	8/22 (36%)
		C2H2 Zn finger	497..517	CDD:275368	5/19 (26%)
		zf-H2C2_2	509..534	CDD:290200	7/24 (29%)
		C2H2 Zn finger	529..545	CDD:275370	1/15 (7%)
		C2H2 Zn finger	564..584	CDD:275368	5/20 (25%)
		zf-H2C2_2	577..600	CDD:290200	11/23 (48%)
		zf-C2H2	590..612	CDD:278523	9/51 (18%)
		C2H2 Zn finger	592..612	CDD:275368	9/49 (18%)
		C2H2 Zn finger	623..643	CDD:275368	6/20 (30%)
		C2H2 Zn finger	651..672	CDD:275368	5/20 (25%)
		C2H2 Zn finger	680..699	CDD:275368	4/18 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	732..763
		PRK04654	<795..911	CDD:135173
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	964..1013
		C2H2 Zn finger	1021..1041	CDD:275368
		Involved in the interaction with CCAR2. /evidence=ECO:0000269\|PubMed:19131338	1041..1342
		C2H2 Zn finger	1049..1069	CDD:275368
		zf-H2C2_5	1075..1097	CDD:290620
		C2H2 Zn finger	1077..1097	CDD:275368
		zf-H2C2_2	1089..1114	CDD:290200
		C2H2 Zn finger	1105..1126	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144314
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940