DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and Sall1

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_001357998.1	Gene:	Sall1 / 58198	MGIID:	1889585	Length:	1323	Species:	Mus musculus

Alignment Length:	731	Identity:	130/731 - (17%)
Similarity:	195/731 - (26%)	Gaps:	330/731 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly   136 LDTLPRIEILERSANTQENQDQLEGAARRLRKRLKAED----------GSSVDKDKDEDGVEETA 190
            |||.|.:..|..|...     .|......|...:|.|:          .|.....|.:.|..:.|
Mouse   543 LDTKPVLPTLTTSVGL-----PLPPTLPSLTPFIKTEEPAPIPISHSAASPQGSVKSDSGAPDLA 602

  Fly   191 EPAPPKKRRGRPRKSDAAVAPPQKPKEDIQLDLKAEELDEFVDEETDPDFSCLVPSDNSSEDDGG 255
            ...|    .|.|.:.:.:..||...|                .||::...|.:..:.||:.:...
Mouse   603 TRNP----SGVPEEVEGSAVPPFGGK----------------GEESNMASSAVPTAGNSTLNSPV 647

  Fly   256 SDGFDSDSDFELDNGKQEFAVLPKRTVVRPKKYKKRTKPAEP------KVRM-------SRELLE 307
            :||....:.|                          |.|..|      |.:.       |.:..|
Mouse   648 ADGGPGGTTF--------------------------TNPLLPLMSEQFKAKFPFGGLLDSAQASE 686

  Fly   308 QRKKQQ--EEYDVIIAKFFTSVLPCAICNLLVHNFTEMQRHHRLTHQVD-PGYMMCCGRKFTQRK 369
            ..|.||  |..|    |..|....|.||:.::...:.::.|:| ||..: |.....|||.||.:.
Mouse   687 TSKLQQLVENID----KKATDPNECIICHRVLSCQSALKMHYR-THTGERPFKCKICGRAFTTKG 746

  Fly   370 VLAEHVLVH-----WNPDHFKCSVCEKSFQNSRHLESHQQVHM---------------------- 407
            .|..|..||     ....| .|.:|:|.|.|:..|:.|.::||
Mouse   747 NLKTHYSVHRAMPPLRVQH-SCPICQKKFTNAVVLQQHIRMHMGGQIPNTPVPDNYPESMESDTG 810

  Fly   408 ----------------------------------------------------------------- 407

Mouse   811 SFDEKNFDDLDNFSDENMEECPEGSIPDTPKSADASQDSLSSSPLPLEMSSIAALENQMKMINAG 875

  Fly   408 ---------------------------------------DPAVK--------------------- 412
                                                   .||:.
Mouse   876 LAEQLQASLKSVENGSMEGDVLTNDSSSVGGDMESQSAGSPAISESTSSMQALSPSNSTQEFHKS 940

  Fly   413 ------------------------------LTFS---------------------------CDLC 420
                                          ||.|                           ||:|
Mouse   941 PGMEEKPQRVGPGEFANGLSPTPVNGGALDLTSSHAEKIIKEDSLGILFPFRDRGKFKNTACDIC 1005

  Fly   421 SKTFLSKTAIDYHKLNKHVPKSEFKFTCSECNKKFLTERKLKNHM---------SSMHDPES--- 473
            .|||..::|:|.| ...|.  .|..|.|:.||:.|.|:..||.||         |.:.:|.|
Mouse  1006 GKTFACQSALDIH-YRSHT--KERPFICTVCNRGFSTKGNLKQHMLTHQMRDLPSQLFEPSSNLG 1067

  Fly   474 ------TIICDKCGKQMRTKIILKKHQELMHSDKPRPEPELQQCQICGAWLKGMTGLKQHMKSIH 532
                  .|..:.....::|::....|.....| |..|...:.|..:..:....:.     :.::.
Mouse  1068 PNQNSAVIPANSLSSLIKTEVNGFVHVSPQDS-KDAPTSHVPQGPLSSSATSPVL-----LPALP 1126

  Fly   533 VESAGEHRCHICAKVSPNARALRRHIYHNHECERKFKCTMCEKAFKRPQELKEHTSTH------- 590
            ..:..:|.|:.|.|...::.||:.| ...|..|:.|.||:|.:||.....||.|..||
Mouse  1127 RRTPKQHYCNTCGKTFSSSSALQIH-ERTHTGEKPFACTICGRAFTTKGNLKVHMGTHMWNSTPA 1190

  Fly   591 -TGEVLYTCPNCPMTF 605
             .|..|..  :.||||
Mouse  1191 RRGRRLSV--DGPMTF 1204

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856	14/76 (18%)
		C2H2 Zn finger	330..351	CDD:275368	5/20 (25%)
		C2H2 Zn finger	360..378	CDD:275368	7/17 (41%)
		LIM	361..>400	CDD:295319	15/43 (35%)
		C2H2 Zn finger	386..406	CDD:275368	7/19 (37%)
		zf-C2H2_8	389..465	CDD:292531	32/279 (11%)
		C2H2 Zn finger	417..438	CDD:275368	9/20 (45%)
		C2H2 Zn finger	448..465	CDD:275368	7/16 (44%)
		C2H2 Zn finger	477..498	CDD:275368	2/20 (10%)
		C2H2 Zn finger	511..532	CDD:275368	0/20 (0%)
		C2H2 Zn finger	541..562	CDD:275368	6/20 (30%)
		C2H2 Zn finger	570..590	CDD:275368	8/19 (42%)
		C2H2 Zn finger	598..619	CDD:275368	4/8 (50%)
Sall1	NP_001357998.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..41
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	78..128
		SUF4-like	449..536	CDD:411020
		C2H2 Zn finger	452..473	CDD:411020
		C2H2 Zn finger	452..472	CDD:275368
		C2H2 Zn finger	480..500	CDD:411020
		C2H2 Zn finger	480..500	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	578..659		18/126 (14%)
		COG5048	700..1168	CDD:227381	77/479 (16%)
		C2H2 Zn finger	707..727	CDD:275368	5/20 (25%)
		zf-H2C2_2	719..744	CDD:404364	9/25 (36%)
		C2H2 Zn finger	735..755	CDD:275368	7/19 (37%)
		zf-C2H2	765..787	CDD:395048	8/22 (36%)
		C2H2 Zn finger	767..787	CDD:275368	7/19 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	789..855		0/65 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	891..961		2/69 (3%)
		C2H2 Zn finger	1002..1022	CDD:275370	9/20 (45%)
		SUF4-like	1005..>1049	CDD:411020	19/46 (41%)
		C2H2 Zn finger	1005..1023	CDD:411020	7/18 (39%)
		zf-C2H2	1028..1050	CDD:395048	10/21 (48%)
		C2H2 Zn finger	1030..1050	CDD:275370	9/19 (47%)
		C2H2 Zn finger	1030..1049	CDD:411020	9/18 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1094..1119		4/25 (16%)
		SUF4-like	1133..>1180	CDD:411020	17/47 (36%)
		C2H2 Zn finger	1135..1156	CDD:411020	6/21 (29%)
		C2H2 Zn finger	1135..1155	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1163..1183	CDD:275368	8/19 (42%)
		C2H2 Zn finger	1163..1180	CDD:411020	7/16 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910