DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and Zfp112

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_036009176.1	Gene:	Zfp112 / 57745	MGIID:	1929115	Length:	883	Species:	Mus musculus

Alignment Length:	735	Identity:	160/735 - (21%)
Similarity:	240/735 - (32%)	Gaps:	218/735 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 NQHFPVQISKESD-ERICGR------------------------CWKIVSDFHTLHEFVSAAQSS 78
            ||.||...|::|. |...||                        ||   |.:|:.:|.:.:...|
Mouse   175 NQEFPPPRSQQSQGEPYLGRPCVTCQWKGQQTSIRNHFCRYGSVCW---SPYHSDNEELYSKGKS 236

  Fly    79 L-------QETKVALMEDDPLTQETTSFPEIIKLATQEEEGVTEPQELGGRNFFYPEIKIEE--- 133
            .       :..||.|:..|           .|:|.       .||         .|..|..|
Mouse   237 YGFHDDRGKTVKVLLLNQD-----------FIELG-------PEP---------CPRTKNREAWG 274

  Fly   134 HELDTLPRIEILERSANTQENQDQLEGAARRLRKRLKAE---DGSSVDKDKDEDGVEETAEPAPP 195
            |:.|         .|::|.:   |.....:...:.|..|   |.|::......:..:|.|:.:||
Mouse   275 HDND---------HSSHTHQ---QCHSRGKPCTRSLSGEGCGDRSALHGHPGLEAGDEGADGSPP 327

  Fly   196 KKRRGR------PRKSDAAV-----------APPQKPKEDIQLDLKA----------------EE 227
            .:...|      ||:....|           |.|....:...:..:|                ||
Mouse   328 LQSSPRVCMEQVPRECSGNVHYGSPLNTCGCAHPGNTSQTCSIPKQAVGSPVHCNSTFRAHPREE 392

  Fly   228 LDEFVDEETDPDF---SCLVPSDNSSEDDGGSDGF---------------------------DSD 262
            .:.:  ||....|   |||..|.....::....|.                           |..
Mouse   393 PNNY--EENRNVFNQSSCLQVSRKIGAEEKLCQGVECRKNFTHCSSLNIPHRVPVEETLCNPDCG 455

  Fly   263 SDFELDNGKQEFAVL-----PKRTVVRP-----------KKYKKRTKPAEPKVRMSRELLEQRKK 311
            :.|.|....|:|..:     |...:.|.           :|...|.||:..:...........|.
Mouse   456 NHFSLPPHFQDFPGVRAREQPHNRLCRTGFSQTLCLQGHQKLHIREKPSHREGGSGCNWSSTPKD 520

  Fly   312 QQEEYDVIIAKFFTSVLPCAICNLLVHNFTEMQRHHRLTHQVDPGYMMC--CGRKFTQRKVLAEH 374
            .|::          .:..|..|.....:.:.:..|||: |..:..| .|  ||:.|::...|..|
Mouse   521 PQKQ----------KLHKCNACGKGFSHRSVLDIHHRI-HTGEKPY-KCEECGKGFSRSAYLQGH 573

  Fly   375 VLVHWNPDHFKCSVCEKSFQNSRHLESHQQVHMDPAVKLTFSCDLCSKTFLSKTAIDYHKLNKHV 439
            ..||.....:||..|.|.|..|.||:.||:||..   :..:.|:.|.|.|.....:..|   :.|
Mouse   574 QRVHTGEKPYKCEECGKGFSRSSHLQGHQRVHTG---EKPYKCEECGKGFSWSFNLQIH---QRV 632

  Fly   440 PKSEFKFTCSECNKKFLTERKLKNHMSSMHDPESTIICDKCGKQMRTKIILKKHQELMHSDKPRP 504
            ...|..:.|.||.|.|.....|..| ..:|..|....|.:|||....|..|:.||.:...::|
Mouse   633 HTGEKPYKCGECGKGFSKASTLLAH-ERVHTGEKPYQCHECGKNFSQKSYLQSHQSVHSGERP-- 694

  Fly   505 EPELQQCQICG------AWLKGMTGLKQHMKSIHVESAGE--------------------HRCHI 543
                ..|::||      |:|:|...:...:|....|..|:                    .:|..
Mouse   695 ----HICEVCGKGFSQRAYLQGHLRVHTRVKPYKCEVCGKGFSQGSRLEAHQRVHTGRKPFKCET 755

  Fly   544 CAKVSPNARALRRHIYHNHECERKFKCTMCEKAFKRPQELKEHTSTHTGEVLYTCPNCPMTFFCS 608
            |.|....:..|:.| ...||..|.:||..|.|.|.....|:.|...||||..|.|..|...|...
Mouse   756 CTKGFSESSRLQAH-QRIHEEGRPYKCDQCGKGFSGYSSLQAHHRVHTGEKPYKCEVCGKGFSQR 819

  Fly   609 ANMYKHRQRLHRAQ--YEAD 626
            :|:..| ||:|..:  |..|
Mouse   820 SNLQAH-QRVHTGEKPYTCD 838

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071	15/73 (21%)
		FYDLN_acid	<191..268	CDD:302856	21/139 (15%)
		C2H2 Zn finger	330..351	CDD:275368	5/20 (25%)
		C2H2 Zn finger	360..378	CDD:275368	6/19 (32%)
		LIM	361..>400	CDD:295319	14/38 (37%)
		C2H2 Zn finger	386..406	CDD:275368	9/19 (47%)
		zf-C2H2_8	389..465	CDD:292531	23/75 (31%)
		C2H2 Zn finger	417..438	CDD:275368	5/20 (25%)
		C2H2 Zn finger	448..465	CDD:275368	6/16 (38%)
		C2H2 Zn finger	477..498	CDD:275368	8/20 (40%)
		C2H2 Zn finger	511..532	CDD:275368	7/26 (27%)
		C2H2 Zn finger	541..562	CDD:275368	5/20 (25%)
		C2H2 Zn finger	570..590	CDD:275368	6/19 (32%)
		C2H2 Zn finger	598..619	CDD:275368	7/20 (35%)
Zfp112	XP_036009176.1	KRAB	12..72	CDD:214630
		COG5048	251..716	CDD:227381	110/530 (21%)
		C2H2 Zn finger	481..498	CDD:275368	2/16 (13%)
		C2H2 Zn finger	529..549	CDD:275368	5/20 (25%)
		C2H2 Zn finger	557..577	CDD:275368	6/19 (32%)
		C2H2 Zn finger	585..605	CDD:275368	9/19 (47%)
		C2H2 Zn finger	613..633	CDD:275368	5/22 (23%)
		C2H2 Zn finger	641..661	CDD:275368	7/20 (35%)
		C2H2 Zn finger	669..689	CDD:275368	8/19 (42%)
		COG5048	<674..842	CDD:227381	45/173 (26%)
		C2H2 Zn finger	697..717	CDD:275368	6/19 (32%)
		C2H2 Zn finger	725..745	CDD:275368	2/19 (11%)
		C2H2 Zn finger	753..773	CDD:275368	5/20 (25%)
		C2H2 Zn finger	781..801	CDD:275368	6/19 (32%)
		C2H2 Zn finger	809..829	CDD:275368	7/20 (35%)
		C2H2 Zn finger	837..857	CDD:275368	1/2 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910