DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and ZNF471

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_065864.2	Gene:	ZNF471 / 57573	HGNCID:	23226	Length:	626	Species:	Homo sapiens

Alignment Length:	582	Identity:	134/582 - (23%)
Similarity:	206/582 - (35%)	Gaps:	123/582 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 IKIEEHELDTLPRIEILERSANTQENQDQLEGAARRLRKRLKAED-------GSSVDKDKDEDGV 186
            :|:...:|.|...:.|    ..:||....:..|.:||.:.:..|:       |..:.|......:
Human     6 VKVMPQDLVTFKDVAI----DFSQEEWQWMNPAQKRLYRSMMLENYQSLVSLGLCISKPYVISLL 66

  Fly   187 EETAEPAPPKKRRGRPRKSD--AAVAPPQKPKEDIQLDLKAEELDEFVDEETDPDFSCLVPSDNS 249
            |:..||........|...||  :.....:.|.:....|      |..::..|.....|....:|.
Human    67 EQGREPWEMTSEMTRSPFSDWESIYVTQELPLKQFMYD------DACMEGITSYGLECSTFEENW 125

  Fly   250 SEDDGGSDGFDSDSDFELDNGKQEF-----AVLPKRTVVRPK--KYKKRTK-------------- 293
            ..:|          .||...|..|.     .:..|.|:.:..  ||.|..|
Human   126 KWED----------LFEKQMGSHEMFSKKEIITHKETITKETEFKYTKFGKCIHLENIEESIYNH 180

  Fly   294 PAEPKVRMSRELLEQRKKQQEEYDVIIAKFFTSVLPCAICNLLVHNFTEMQRHHRLTHQVDPGYM 358
            .::.|......::.:.||      |.:.|   .:..|..|:....:.:.:..|.|: |..:..|
Human   181 TSDKKSFSKNSMVIKHKK------VYVGK---KLFKCNECDKTFTHSSSLTVHFRI-HTGEKPY- 234

  Fly   359 MC--CGRKFTQRKVLAEHVLVHWNPDHFKCSVCEKSFQNSRHLESHQQVH--------------- 406
            .|  ||:.|.||:.||:|...|.....|:|..|.|:|:.|.||..||::|
Human   235 ACEECGKAFKQRQHLAQHHRTHTGEKLFECKECRKAFKQSEHLIQHQRIHTGEKPYKCKECRKAF 299

  Fly   407 MDPA----------VKLTFSCDLCSKTFLSKTAIDYHKLNKHVPKSEFKFTCSECNKKFLTERKL 461
            ..||          .:..:.|..|.|.|...::...|: ..|..|..::  |.||.|.|......
Human   300 RQPAHLAQHQRIHTGEKPYECKECGKAFSDGSSFARHQ-RCHTGKRPYE--CIECGKAFRYNTSF 361

  Fly   462 KNHMSSMHDPESTIICDKCGKQMRTKIILKKHQELMHSDKPRPEPELQQCQICGAWLKGMTGLKQ 526
            ..|..|.|..|....|..|||.....|.|..|:.:...:||      .:|.:||......:....
Human   362 IRHWRSYHTGEKPFNCIDCGKAFSVHIGLILHRRIHTGEKP------YKCGVCGKTFSSGSSRTV 420

  Fly   527 HMKSIHVESAGE--HRCHICAKVSPNARALRRHIYHNHECERKFKCTMCEKAFKRPQELKEHTST 589
            |.: ||   .||  :.|.||.|...:..:|.:| ...|..|:.::|..|.|||::...|..|...
Human   421 HQR-IH---TGEKPYECDICGKDFSHHASLTQH-QRVHSGEKPYECKECGKAFRQNVHLVSHLRI 480

  Fly   590 HTGEVLYTCPNCPMTFFCSANMYKH-------------------RQRLHRAQYEADKNQPKP 632
            ||||..|.|..|...|..|:.:..|                   :||.|.||::......||
Human   481 HTGEKPYECKECGKAFRISSQLATHQRIHTGEKPYECIECGNAFKQRSHLAQHQKTHTGEKP 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856	14/78 (18%)
		C2H2 Zn finger	330..351	CDD:275368	4/20 (20%)
		C2H2 Zn finger	360..378	CDD:275368	9/19 (47%)
		LIM	361..>400	CDD:295319	16/38 (42%)
		C2H2 Zn finger	386..406	CDD:275368	9/19 (47%)
		zf-C2H2_8	389..465	CDD:292531	23/100 (23%)
		C2H2 Zn finger	417..438	CDD:275368	5/20 (25%)
		C2H2 Zn finger	448..465	CDD:275368	5/16 (31%)
		C2H2 Zn finger	477..498	CDD:275368	7/20 (35%)
		C2H2 Zn finger	511..532	CDD:275368	4/20 (20%)
		C2H2 Zn finger	541..562	CDD:275368	6/20 (30%)
		C2H2 Zn finger	570..590	CDD:275368	7/19 (37%)
		C2H2 Zn finger	598..619	CDD:275368	7/39 (18%)
ZNF471	NP_065864.2	KRAB	14..73	CDD:214630	12/62 (19%)
		KRAB	14..53	CDD:279668	8/42 (19%)
		COG5048	203..610	CDD:227381	95/359 (26%)
		C2H2 Zn finger	208..228	CDD:275368	4/20 (20%)
		zf-H2C2_2	220..245	CDD:290200	8/26 (31%)
		C2H2 Zn finger	236..256	CDD:275368	9/19 (47%)
		zf-H2C2_2	248..273	CDD:290200	9/24 (38%)
		C2H2 Zn finger	264..284	CDD:275368	9/19 (47%)
		zf-H2C2_2	276..301	CDD:290200	5/24 (21%)
		C2H2 Zn finger	292..312	CDD:275368	2/19 (11%)
		zf-H2C2_2	304..328	CDD:290200	3/23 (13%)
		C2H2 Zn finger	320..340	CDD:275368	5/20 (25%)
		zf-H2C2_2	332..357	CDD:290200	8/27 (30%)
		C2H2 Zn finger	348..366	CDD:275368	6/17 (35%)
		C2H2 Zn finger	377..397	CDD:275368	7/19 (37%)
		zf-H2C2_2	393..414	CDD:290200	6/26 (23%)
		C2H2 Zn finger	405..425	CDD:275368	4/20 (20%)
		zf-H2C2_2	420..442	CDD:290200	9/25 (36%)
		C2H2 Zn finger	433..453	CDD:275368	6/20 (30%)
		zf-H2C2_2	445..470	CDD:290200	9/25 (36%)
		C2H2 Zn finger	461..481	CDD:275368	7/19 (37%)
		zf-H2C2_2	473..496	CDD:290200	9/22 (41%)
		C2H2 Zn finger	489..509	CDD:275368	5/19 (26%)
		zf-H2C2_2	502..526	CDD:290200	1/23 (4%)
		C2H2 Zn finger	517..537	CDD:275368	5/19 (26%)
		zf-H2C2_2	529..554	CDD:290200	5/14 (36%)
		C2H2 Zn finger	545..565	CDD:275368
		zf-H2C2_2	557..581	CDD:290200
		C2H2 Zn finger	573..593	CDD:275368
		C2H2 Zn finger	601..621	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910