DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and ZNF398

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_011514741.1	Gene:	ZNF398 / 57541	HGNCID:	18373	Length:	647	Species:	Homo sapiens

Alignment Length:	673	Identity:	150/673 - (22%)
Similarity:	229/673 - (34%)	Gaps:	176/673 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 IDVHSARGDQLEVTTIVNQHFPVQISKESDERICGRCWKIVSDFHTLHEFVSAAQSSLQETKVAL 86
            :::||.|...||..|            .:.|:....|.|.|::.....|...|...:|      |
Human    62 VEIHSRRLLHLEGRT------------GTAEKKLASCEKTVTELGNQLEGKWAVLGTL------L 108

  Fly    87 MEDDPLTQETTSFPEIIKLATQEEEGVTEPQELGGRNFFY----PEIKIEEHELDTLPRIEILER 147
            .|...|.:...:...:::                .|||:.    |.||      ..:|::.:...
Human   109 QEYGLLQRRLENLENLLR----------------NRNFWILRLPPGIK------GDIPKVPVAFD 151

  Fly   148 SAN---TQENQDQLEGAARRLRKR-LKAEDGSSVDKD--------------------KDEDGVEE 188
            ..:   :....::||...:.|.|. :|....|.:..|                    :|:.|.||
Human   152 DVSIYFSTPEWEKLEEWQKELYKNIMKGNYESLISMDYAINQPDVLSQIQPEGEHNTEDQAGPEE 216

  Fly   189 TAEPAPPKKRRG----------RPRKSDAAVAPPQKPKEDI--------QLDLKAEELDEFVDEE 235
            :..|..|.:..|          :..:.....|||:..:.|:        :|.:|||.|   ....
Human   217 SEIPTDPSEEPGISTSDILSWIKQEEEPQVGAPPESKESDVYKSTYADEELVIKAEGL---ARSS 278

  Fly   236 TDPDFSCLVPSDNSSEDDGGSDGFDSDSDFELDNGKQEFAVLPKRTVVRPKKYKKRTKPAEPKVR 300
            ..|:    ||...||......|.| ||..|:                      .:::....|..|
Human   279 LCPE----VPVPFSSPPAAAKDAF-SDVAFK----------------------SQQSTSMTPFGR 316

  Fly   301 MSRELLEQRKKQQEEYDVIIAKFFTSVLPCAI------CNLLVHNFTEMQRHHRLTHQVDPGYMM 359
            .:.:|.|..:.|     |...:..:..||..:      |            ||
Human   317 PATDLPEASEGQ-----VTFTQLGSYPLPPPVGEQVFSC------------HH------------ 352

  Fly   360 CCGRKFTQRKVLAEHVLVHWNPDHFKCSVCEKSFQNSRHLESHQQVHMDPAVKLTFSCDLCSKTF 424
             ||:..:| .:|..|...|.......|:.|.|.|.....|.|..|.|   |.:...:|..|::||
Human   353 -CGKNLSQ-DMLLTHQCSHATEHPLPCAQCPKHFTPQADLSSTSQDH---ASETPPTCPHCARTF 412

  Fly   425 LSKTAIDYHKLNKHVPKSEFKFTCSECNKKFLTERKLKNHMSSMHDPESTIICDKCGKQMRTKII 489
            ...:.:.|| |..| ..:|..|.|.:|.|:|..:.:|.:|..: |..|....|.:||:....||.
Human   413 THPSRLTYH-LRVH-NSTERPFPCPDCPKRFADQARLTSHRRA-HASERPFRCAQCGRSFSLKIS 474

  Fly   490 LKKHQELMHSDKPRPEPELQQCQICGAWLKGMTGLKQHMKSIHVESAGE--HRCHICAKVSPNAR 552
            |..||.....::|      ..|..||....|.:.|.:| :.||   .||  :.|..|:|......
Human   475 LLLHQRGHAQERP------FSCPQCGIDFNGHSALIRH-QMIH---TGERPYPCTDCSKSFMRKE 529

  Fly   553 ALRRHIYHNHECERKFKCTMCEKAFKRPQELKEHTSTHTGEVLYTCPNCPMTFFCSANMYKHRQR 617
            .|..| ...|..||.|.|..|.|:|.|...|.:|...||||..|.|..|..:|.....:..|.:.
Human   530 HLLNH-RRLHTGERPFSCPHCGKSFIRKHHLMKHQRIHTGERPYPCSYCGRSFRYKQTLKDHLRS 593

  Fly   618 LHRAQYEADKN----QPKPPNIL 636
            .|......|.:    .|.||..|
Human   594 GHNGGCGGDSDPSGQPPNPPGPL 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071	13/58 (22%)
		FYDLN_acid	<191..268	CDD:302856	22/94 (23%)
		C2H2 Zn finger	330..351	CDD:275368	3/26 (12%)
		C2H2 Zn finger	360..378	CDD:275368	5/17 (29%)
		LIM	361..>400	CDD:295319	10/38 (26%)
		C2H2 Zn finger	386..406	CDD:275368	7/19 (37%)
		zf-C2H2_8	389..465	CDD:292531	23/75 (31%)
		C2H2 Zn finger	417..438	CDD:275368	7/20 (35%)
		C2H2 Zn finger	448..465	CDD:275368	5/16 (31%)
		C2H2 Zn finger	477..498	CDD:275368	8/20 (40%)
		C2H2 Zn finger	511..532	CDD:275368	6/20 (30%)
		C2H2 Zn finger	541..562	CDD:275368	5/20 (25%)
		C2H2 Zn finger	570..590	CDD:275368	7/19 (37%)
		C2H2 Zn finger	598..619	CDD:275368	4/20 (20%)
ZNF398	XP_011514741.1	DUF3669	62..117	CDD:289202	16/72 (22%)
		KRAB	148..206	CDD:214630	7/57 (12%)
		KRAB_A-box	148..187	CDD:143639	6/38 (16%)
		COG5048	<349..593	CDD:227381	80/286 (28%)
		C2H2 Zn finger	377..397	CDD:275368	7/19 (37%)
		C2H2 Zn finger	405..425	CDD:275368	7/20 (35%)
		C2H2 Zn finger	434..454	CDD:275368	6/20 (30%)
		C2H2 Zn finger	462..482	CDD:275368	8/19 (42%)
		C2H2 Zn finger	490..510	CDD:275368	6/20 (30%)
		zf-H2C2_2	502..525	CDD:290200	9/26 (35%)
		C2H2 Zn finger	518..538	CDD:275368	5/20 (25%)
		zf-H2C2_2	530..555	CDD:290200	10/25 (40%)
		zf-C2H2	544..566	CDD:278523	8/21 (38%)
		C2H2 Zn finger	546..566	CDD:275368	7/19 (37%)
		zf-H2C2_2	558..583	CDD:290200	10/24 (42%)
		C2H2 Zn finger	574..592	CDD:275368	4/17 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910