DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and znf513a

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_001296396.1	Gene:	znf513a / 568216	ZFINID:	ZDB-GENE-030131-9895	Length:	548	Species:	Danio rerio

Alignment Length:	629	Identity:	122/629 - (19%)
Similarity:	191/629 - (30%)	Gaps:	193/629 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 PEIIKLATQEEEGVTEPQELGGRNFFYPEIKIEEHELDTLPRIEILER-SANTQ----ENQDQLE 159
            |:.:||.:::..|...|..|...:.|....::|..:.|...:|..||: ||:..    ...|:..
Zfish     9 PQPVKLDSEDGVGTVRPTNLTFESDFLLGQELEFSDPDNDQKIIGLEKFSADISLPGFPLGDEEN 73

  Fly   160 GAARRLRKRLKAEDGSSVDKDKDEDGVEETAEPAPPKKRRGRPRKSDAAVAPPQKPKEDIQLDLK 224
            ....||.....|:|..:.:.:: |:.|.|:|.|: ....||..:..:..:.|        .:||.
Zfish    74 SPFSRLSMESDADDLRATESER-EERVSESAFPS-YLSCRGCGQLLEDPLGP--------GMDLV 128

  Fly   225 AE--------ELDEFVDEETDPDFSCLVPSDNSSEDDGGSDGFDSDSDFELDNGKQEFAVLPKRT 281
            ..        .::..||.:.     |......:....||::|...|...:|.:
Zfish   129 GPYCMRCCKGNVEGIVDRKL-----CSGLGLQAESRGGGNEGTGEDGSLKLHS------------ 176

  Fly   282 VVRPKKYKKRTKPAEPKVRMSRELLEQRKKQQEEYDVIIAKFFTSVLPCAICNLLVHNFTEMQRH 346
                                                            |.:|. ....:|...:.
Zfish   177 ------------------------------------------------CTLCG-FTSRYTNHVKR 192

  Fly   347 HRLTHQVDPGY-MMCCGRKFTQRKVLAEHVLVHWNPDHFKCSVCEKSFQNSRHLESHQQVH--MD 408
            |..||..:..| ...|.....|...|..|:.:|.....:||:.|..:..:..:|:.||::|  :.
Zfish   193 HMKTHNGEKPYGCPLCSYASAQLVNLQRHLRIHTGEKPYKCNTCTFACSSLGNLKRHQRMHATIG 257

  Fly   409 PAVKLTFSCD---LCSKTFLSK------------------------------TAIDYHKLNKH-- 438
            |...:|....   |...|...|                              ...|..:|.:.
Zfish   258 PGQSVTQPVSGNGLNHSTAAQKEKEAVPAPTEVAGAVRSVTRPHMGRDGNYLQTFDGLRLAQQTS 322

  Fly   439 ---------------VPKSEFKFTCSECNKKFLTERKLKNHMSSMHDPESTIICDKCGKQMRTKI 488
                           :|...|.|||..|......|           |..|..||.||..:|.||.
Zfish   323 TGVLQSGQAASQPAALPPMFFPFTCRLCGMALDDE-----------DGSSAQICAKCTLEMLTKD 376

  Fly   489 I--------------------------LKKHQELMHSDKPRPEPELQQCQICGAWLKGMTGLKQH 527
            .                          |.:|.:....:||...|   ||....|   ....||:|
Zfish   377 THGCPAERGDKVYTCAACPFLTHYPNHLARHMKTHSGEKPYKCP---QCDYASA---HFDNLKRH 435

  Fly   528 MKSIHVESAGE--HRCHICAKVSPNARALRRHIYHNHECERKFKCTMCEKAFKRPQELKEHTSTH 590
                |....||  ::||:|.....|...|:|| ...|...:.|:|.:|..:..:...||.|...|
Zfish   436 ----HRVHTGEKPYKCHLCDYACGNLANLKRH-QRVHSGAKPFQCAICNYSCNQSMNLKRHMLRH 495

  Fly   591 TGEVLYTCPNCPMTFFCSANMYKHRQRLHRAQYEADKNQPKPPN 634
            |||..:.|..|..|.....| ||..|:.|....:.....|.|.|
Zfish   496 TGEKPHKCQECGYTTGHWDN-YKRHQKKHSLAGDGWVKVPLPGN 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856	13/84 (15%)
		C2H2 Zn finger	330..351	CDD:275368	4/20 (20%)
		C2H2 Zn finger	360..378	CDD:275368	4/17 (24%)
		LIM	361..>400	CDD:295319	8/38 (21%)
		C2H2 Zn finger	386..406	CDD:275368	5/19 (26%)
		zf-C2H2_8	389..465	CDD:292531	19/127 (15%)
		C2H2 Zn finger	417..438	CDD:275368	5/53 (9%)
		C2H2 Zn finger	448..465	CDD:275368	3/16 (19%)
		C2H2 Zn finger	477..498	CDD:275368	8/46 (17%)
		C2H2 Zn finger	511..532	CDD:275368	5/20 (25%)
		C2H2 Zn finger	541..562	CDD:275368	7/20 (35%)
		C2H2 Zn finger	570..590	CDD:275368	5/19 (26%)
		C2H2 Zn finger	598..619	CDD:275368	7/20 (35%)
znf513a	NP_001296396.1	C2H2 Zn finger	177..197	CDD:275368	4/20 (20%)
		zf-H2C2_2	189..214	CDD:290200	5/24 (21%)
		COG5048	201..>503	CDD:227381	68/323 (21%)
		C2H2 Zn finger	205..225	CDD:275368	4/19 (21%)
		zf-H2C2_2	217..242	CDD:290200	6/24 (25%)
		C2H2 Zn finger	233..253	CDD:275368	5/19 (26%)
		C2H2 Zn finger	391..411	CDD:275368	2/19 (11%)
		zf-H2C2_2	403..428	CDD:290200	8/30 (27%)
		C2H2 Zn finger	419..439	CDD:275368	8/29 (28%)
		zf-H2C2_2	431..454	CDD:290200	9/26 (35%)
		C2H2 Zn finger	447..467	CDD:275368	7/20 (35%)
		zf-H2C2_2	459..484	CDD:290200	7/25 (28%)
		C2H2 Zn finger	475..495	CDD:275368	5/19 (26%)
		zf-H2C2_2	487..510	CDD:290200	9/22 (41%)
		C2H2 Zn finger	503..523	CDD:275368	7/20 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100