DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and si:ch211-216l23.1

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_005159186.1	Gene:	si:ch211-216l23.1 / 566696	ZFINID:	ZDB-GENE-060503-121	Length:	1372	Species:	Danio rerio

Alignment Length:	667	Identity:	124/667 - (18%)
Similarity:	195/667 - (29%)	Gaps:	253/667 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   196 KKRRGRPRKSDAAVAPPQKPK------EDIQLDLKAEELDEFVDEETDPDFSCLVPSD-----NS 249
            ::::.:|| |..||...:..:      ..:|.|....|.|      :|...|..|..|     .|
Zfish     3 RRKQAKPR-SVKAVEEAESTECASGWDSSVQTDAAVSERD------SDRKESRAVGEDGEQSVTS 60

  Fly   250 SEDDGGSDGFDSDSDFELDNGKQEFAVLPKRTVVR-----------PKKYKKRTKPAEPKVRMSR 303
            .::..|.:..|.||.|..||.:|:|..|...|..|           |......:.|:...|....
Zfish    61 HDERVGEEDLDDDSIFTCDNCQQDFECLADLTEHRTNHCPADGDDDPGLSWVASSPSSKDVASPS 125

  Fly   304 ELL------------EQRKKQQEEYDVIIAKFFTSVLPCAICNLLVHNFTEMQRHHRLTHQVDPG 356
            ::|            |:.......|            ||..|:......:.::||.::.....|.
Zfish   126 QMLGDGCCDMGMGTGEEEGGSGLPY------------PCQFCDKSFSRLSYLKRHEQIHSDKLPF 178

  Fly   357 YMMCCGRKFTQRKVLAEHVLVHW---------------NPDH-------------FKCSVCEKSF 393
            ....|.|.|..::....||.:|.               ..||             ||||:|::.|
Zfish   179 KCTFCSRLFKHKRSRDRHVKLHTGDKKYSCQECEAAFSRSDHLKIHLKTHSSSKPFKCSICKRGF 243

  Fly   394 QNSRHLESHQQVHMDPAVKLT---------------------FSCDLCSKTFLSKTAIDYHKLNK 437
            .::..|:||.|.|......|.                     :.||.|.:||.....::.|.|.:
Zfish   244 SSTSSLQSHMQAHRKNKEHLAKKDQGKRDGSSSDVTEQDQDLYMCDYCEETFSQTDELEKHVLTQ 308

  Fly   438 HVPKSE-FKFTCSECNKKFLTERKLKNHMSSMH-------------------------------- 469
            |...|: .:..|..|.:.|..|..|..|:...|
Zfish   309 HPQLSDRAELQCIHCPEIFSDEGTLLTHIDRTHANKKHKCPMCAEQFPSVEDVYCHLDSHRQPDS 373

  Fly   470 --------------------------------DPESTI--------------------------I 476
                                            .|:||:                          .
Zfish   374 SNHSASPDPVLGSVASMSSATPDSSASLERGSTPDSTLKPGQSRRKLAPSSDHDDGTWSGKVTYS 438

  Fly   477 CDKCGKQ-MRTKIILKKHQELMHSDKPRPEPELQQCQICGAWLKGMTGLKQHMKSIHVESAGE-- 538
            |..|.|: ..:..:|:.|.:.:|:|||:   :...||:|...|..:..|.:|::..|..|...
Zfish   439 CPYCSKRDFNSLAVLEIHLKTIHADKPQ---QSHTCQLCLETLPTLYNLNEHVRKAHRSSGNSAS 500

  Fly   539 ------------HRCHICAKVSPNARALRRHIYHNH-------------ECERKFKCTMCEKAFK 578
                        ..|:.|..:..:..:|:.||..:|             |....|.|..|...|.
Zfish   501 NFPLLQFSNVSAFHCNYCPDMFADINSLQEHIRVSHCLSGGVVAGSTTLEGNHAFFCNQCSMGFL 565

  Fly   579 RPQELKEH-TSTHTGEV-------------------LYTCPNCPMT--FFCSANMYKHRQRLHRA 621
            ....|.|| ..||...|                   :|:||.|..:  |.....:.||.:..|
Zfish   566 TESSLTEHIQQTHCSSVGGVTKMESPVLQPSQSFMEVYSCPYCTNSPIFGSLLKLTKHIKENH-- 628

  Fly   622 QYEADKNQPKPPNILKI 638
                 ||.|...|..|:
Zfish   629 -----KNIPLANNKRKV 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856	19/82 (23%)
		C2H2 Zn finger	330..351	CDD:275368	4/20 (20%)
		C2H2 Zn finger	360..378	CDD:275368	5/17 (29%)
		LIM	361..>400	CDD:295319	14/66 (21%)
		C2H2 Zn finger	386..406	CDD:275368	8/19 (42%)
		zf-C2H2_8	389..465	CDD:292531	22/97 (23%)
		C2H2 Zn finger	417..438	CDD:275368	7/20 (35%)
		C2H2 Zn finger	448..465	CDD:275368	5/16 (31%)
		C2H2 Zn finger	477..498	CDD:275368	5/21 (24%)
		C2H2 Zn finger	511..532	CDD:275368	6/20 (30%)
		C2H2 Zn finger	541..562	CDD:275368	5/20 (25%)
		C2H2 Zn finger	570..590	CDD:275368	6/20 (30%)
		C2H2 Zn finger	598..619	CDD:275368	6/22 (27%)
si:ch211-216l23.1	XP_005159186.1	COG5048	<151..256	CDD:227381	24/104 (23%)
		C2H2 Zn finger	152..172	CDD:275368	4/19 (21%)
		C2H2 Zn finger	180..200	CDD:275368	5/19 (26%)
		COG5048	206..>539	CDD:227381	56/335 (17%)
		C2H2 Zn finger	208..228	CDD:275368	2/19 (11%)
		C2H2 Zn finger	236..256	CDD:275368	8/19 (42%)
		C2H2 Zn finger	288..307	CDD:275368	6/18 (33%)
		C2H2 Zn finger	439..460	CDD:275368	5/20 (25%)
		C2H2 Zn finger	471..492	CDD:275368	6/20 (30%)
		C2H2 Zn finger	515..534	CDD:275368	5/18 (28%)
		C2H2 Zn finger	677..697	CDD:275368
		C2H2 Zn finger	707..728	CDD:275368
		C2H2 Zn finger	738..755	CDD:275368
		C2H2 Zn finger	766..783	CDD:275368
		C2H2 Zn finger	796..817	CDD:275368
		C2H2 Zn finger	833..853	CDD:275368
		C2H2 Zn finger	859..877	CDD:275368
		C2H2 Zn finger	956..977	CDD:275368
		C2H2 Zn finger	1002..1022	CDD:275368
		C2H2 Zn finger	1031..1051	CDD:275368
		C2H2 Zn finger	1288..1308	CDD:275368
		C2H2 Zn finger	1319..1340	CDD:275368
		C2H2 Zn finger	1349..1365	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910