DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and znf526

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_694427.4	Gene:	znf526 / 566071	ZFINID:	ZDB-GENE-100922-260	Length:	1057	Species:	Danio rerio

Alignment Length:	798	Identity:	166/798 - (20%)
Similarity:	261/798 - (32%)	Gaps:	244/798 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SSPSCLLCMCEYPAMMGDYIDVHSARGDQLEVTTIVNQHFPVQISKESDERI-------CGRCWK 60
            |:||.|    ....::...:.....|.|.:....::.....|...|:.:|.|       |..|..
Zfish   221 SAPSTL----RKAKLLSPLLPAEPIRLDNVTTLNLLPSSGQVNAVKKENEEILIIHPYECSECNL 281

  Fly    61 IVSDFHTLHEFVSAAQSSLQETKVALMEDDPLTQET---TSFPEIIKLATQEEEGVTEPQE---- 118
            :   |.|..:|       ||......:..|..|.:|   ..:.:  .|..:::||.::..|
Zfish   282 L---FSTPEDF-------LQHQGEHFLGQDKETGDTGVMVGYED--SLGAKDDEGRSDGSEEGKV 334

  Fly   119 ---LGGRNFFY--------------PEIKIEE-----------------HELDT--LPRIE-ILE 146
               .|||..:.              ..::.||                 ||..|  .|..: :.:
Zfish   335 GRVSGGRRMYTARSAGLGLTSPVSPSSLRCEECNRTFTSANRLVAHLRVHEQGTHECPECDKVFK 399

  Fly   147 RSANTQENQDQLEGAARRL-----------------RKR----------LKAEDGSSVDKDKDED 184
            :..:.|.:.....|.||.|                 ||.          ..|:..:::.|.....
Zfish   400 KLVSLQTHMRTHSGEARFLCVDCGHGFTTEMTLMIHRKSHTSEPLHKCPFCAKTFTNMTKFLYHR 464

  Fly   185 GVEETAEPAPPKK-------------RRGRPRKSDAAVAPPQKPKEDIQLDLKAEELD------- 229
            ......||..|..             :|.|.|:     |..:|.::.:.:..|.|..|
Zfish   465 RTHRVREPTTPVSQFVLAQQSPVSIIQRARERE-----AAWRKDRQVLTIPSKDESSDAGPVLIE 524

  Fly   230 --EFVDEETDPDFSCL-VPSDNSSEDDGGSDGFDSDSDFELDNGKQEFAVLPKRTVVRPKKYKKR 291
              ..|.:.|:|..:.| |...|:.:...|......|.:: |...|.|...:.          .||
Zfish   525 GITVVSQSTEPTENGLYVEPSNTEQTQNGGKRLADDPNY-LTIAKSEGGGVE----------DKR 578

  Fly   292 TKPA---EPKVRMSRELLEQRKKQQEEYDVIIAKFFTSVLPCAICNLLVHNFTEMQRHHRLTHQV 353
            ..||   :||                             .||:||.....:...:.||.|.||..
Zfish   579 MVPAAEEDPK-----------------------------FPCSICGKRFSSQVRLLRHRRTTHTT 614

  Fly   354 D-----------------------------PGYMMCCGRKFTQRKVLAEHVLVHWNPDHFKCSVC 389
            :                             |.....||:.|:....|:.|.|.|.....::|.:|
Zfish   615 ERRFKCNICGKPFKKQIHLRNHLRTHTGERPFQCSVCGKTFSSLANLSRHGLTHTGVRPYRCDIC 679

  Fly   390 EKSFQNSRHLESHQQVHMDPAVKLTFSCDLCSKTFLSKTAIDYHKLNKHVPKSEFKFTCSECNKK 454
            .|:|..|.:|..|:| |:...|..: ||..||.||:....:..|:...| |.|...:.|..|.:.
Zfish   680 HKAFSQSSNLRQHRQ-HLHSNVTPS-SCPDCSATFIRPAKLVAHRFLHH-PGSPAPYPCPHCTEG 741

  Fly   455 FLTERKLKNHMSSMHD--------------------------------PESTIICDKCGKQMRTK 487
            ||.:|:...|....|.                                |:..:.|..|||::.:.
Zfish   742 FLRKRQRDVHCLEEHPCLAQPHSISQESQGRGQEGSADDTEQQSASSIPKPNLDCTICGKRLNSP 806

  Fly   488 IILKKHQELMHSDKP-RPE------PELQQCQICGAWLKGMTGLKQHMKSIHVESAGE--HRCHI 543
            ..|:.|| |.|...| ||.      .:...|.:||......:.:..|.: :|   .||  :.|.|
Zfish   807 ANLRLHQ-LSHGLGPGRPRGSSSNTGKSHPCPVCGKLFVSASSVTLHQR-VH---TGERPYPCAI 866

  Fly   544 CAKVSPNARALRRHIYHNHECERKFKCTMCEKAFKRPQELKEHTSTHTGEVLYTCPNCPMTFFCS 608
            |.|.......||.|: ..|..||.|:|..|:|.|.:...|.||..|||||..:.|..|..||...
Zfish   867 CGKRFRQNTHLREHL-RTHSGERPFRCEFCDKGFVQSMHLAEHRRTHTGERPHACGECGKTFKTI 930

  Fly   609 ANMYKHRQRLHRAQYEAD 626
            :|:..||:...|:|.:.:
Zfish   931 SNLRTHRKTHSRSQKQQE 948

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071	13/80 (16%)
		FYDLN_acid	<191..268	CDD:302856	19/99 (19%)
		C2H2 Zn finger	330..351	CDD:275368	6/20 (30%)
		C2H2 Zn finger	360..378	CDD:275368	6/17 (35%)
		LIM	361..>400	CDD:295319	12/38 (32%)
		C2H2 Zn finger	386..406	CDD:275368	8/19 (42%)
		zf-C2H2_8	389..465	CDD:292531	24/75 (32%)
		C2H2 Zn finger	417..438	CDD:275368	6/20 (30%)
		C2H2 Zn finger	448..465	CDD:275368	5/16 (31%)
		C2H2 Zn finger	477..498	CDD:275368	8/20 (40%)
		C2H2 Zn finger	511..532	CDD:275368	4/20 (20%)
		C2H2 Zn finger	541..562	CDD:275368	7/20 (35%)
		C2H2 Zn finger	570..590	CDD:275368	7/19 (37%)
		C2H2 Zn finger	598..619	CDD:275368	7/20 (35%)
znf526	XP_694427.4	C2H2 Zn finger	13..33	CDD:275368
		C2H2 Zn finger	57..77	CDD:275368
		COG5048	358..714	CDD:227381	76/402 (19%)
		C2H2 Zn finger	364..384	CDD:275368	2/19 (11%)
		zf-C2H2_6	388..414	CDD:290623	3/25 (12%)
		C2H2 Zn finger	391..411	CDD:275368	2/19 (11%)
		C2H2 Zn finger	419..439	CDD:275368	2/19 (11%)
		C2H2 Zn finger	447..467	CDD:275368	2/19 (11%)
		C2H2 Zn finger	591..612	CDD:275368	6/20 (30%)
		COG5048	618..967	CDD:227381	87/340 (26%)
		zf-C2H2	618..640	CDD:278523	0/21 (0%)
		C2H2 Zn finger	620..640	CDD:275368	0/19 (0%)
		zf-H2C2_2	632..657	CDD:290200	4/24 (17%)
		C2H2 Zn finger	648..668	CDD:275368	6/19 (32%)
		zf-H2C2_2	660..685	CDD:290200	8/24 (33%)
		C2H2 Zn finger	676..697	CDD:275368	9/21 (43%)
		C2H2 Zn finger	705..725	CDD:275370	6/19 (32%)
		C2H2 Zn finger	735..752	CDD:275370	5/16 (31%)
		C2H2 Zn finger	796..816	CDD:275368	8/20 (40%)
		C2H2 Zn finger	836..856	CDD:275368	4/20 (20%)
		zf-H2C2_2	852..873	CDD:290200	8/24 (33%)
		C2H2 Zn finger	864..884	CDD:275368	7/20 (35%)
		zf-H2C2_2	876..901	CDD:290200	11/25 (44%)
		C2H2 Zn finger	892..912	CDD:275368	7/19 (37%)
		zf-H2C2_2	904..929	CDD:290200	12/24 (50%)
		C2H2 Zn finger	920..940	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910