DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and si:dkey-154p10.3

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_692110.2	Gene:	si:dkey-154p10.3 / 563659	ZFINID:	ZDB-GENE-070912-380	Length:	646	Species:	Danio rerio

Alignment Length:	749	Identity:	136/749 - (18%)
Similarity:	237/749 - (31%)	Gaps:	295/749 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 HSARGDQLEVTTIVNQHFPVQISKESDERICGRCWKIVSDFHTLHEFVSAAQSSLQETKVALME- 88
            :||.|.:..|:|:| :.|.|::.:   .|||              :|.|:.::.:..   .:||
Zfish    30 NSAVGIEAHVSTLV-EAFLVEVYR---CRIC--------------QFTSSHKAKISH---HVMER 73

  Fly    89 DDPLTQETTSFPEIIKLATQEEEGVTEPQELGGRNFFYPEIKIEEHELDTLPRIEILERSANTQE 153
            .||:    :..|.:..|..::||.:.....:...         ||.|.::.|.....:..:.::.
Zfish    74 HDPV----SPCPHLPCLEKEDEESLCVEMRVNDE---------EEVEHNSSPYDLESDLQSGSKS 125

  Fly   154 NQDQLE-----------GAARRLRKRL------KAEDGS----------------SVDKDKDEDG 185
            |:||::           |..:.:..|.      .:.||:                ..|.:.||:.
Zfish   126 NEDQMDMERISFLLPMYGMFQNISPRSCDIGLGSSSDGNLHVAQTCEVSTLFEEDRHDDNSDEER 190

  Fly   186 V------------------------EETAEPA--------PPKKRRGRPRKSDAAVAPPQKPKE- 217
            |                        ||.|:.|        .....:|:|..:.:|.:.|:..::
Zfish   191 VFQLEDASTDLTVPLNSGMDTEVQDEEMAQSAHLMTLGLCRISSTKGQPSSATSAKSLPEGEQDA 255

  Fly   218 -DIQLDLKAEELDEFVDEETDPDFSCL---------VPSDNSSEDDGGSDGF------------- 259
             |..:|...::.:|      |...:|:         |..|...:...|..||
Zfish   256 GDASMDAVMQKTEE------DGGLACILCQTVASSRVMLDVHLKCHSGEQGFRCPRCGWESEEWA 314

  Fly   260 DSDSDFELDNGKQEFAVLPKRTVVRPKKYKKRTKPAEPKVRMSRELLEQRKKQQEEYDVIIAKFF 324
            |.:..:.| :||:: .....|..|.|:.:::..         ||:..|:|
Zfish   315 DMEHHWRL-HGKRK-GTKRHRCSVCPRSFRRAD---------SRDAHEER--------------- 353

  Fly   325 TSVLPCAICNLLVHNFTEMQRHHRLTHQVDPGYMMCCGRKFTQRKVLAEHVLVHWNPDHFKCSVC 389
                         ||.   |||||.:...:|                            .:||.|
Zfish   354 -------------HNH---QRHHRRSESGEP----------------------------VQCSFC 374

  Fly   390 EKSFQNSRHLESHQQVHMDPAVKLTFSCDLCSKTFLSKTAIDYHKLNKHVP-------------- 440
            .:...:.:..|.||..|:....| ...||...||: .||....|..:|...
Zfish   375 LEWCHSGKEWEIHQHCHVQGGFK-CLHCDFKEKTW-KKTLKHIHTQHKQAEANQDNQIAHSRDIQ 437

  Fly   441 --KSEFKFTCSECNKKF-------LTERKLKN-----------------HMSSMHDPESTI---- 475
              .|..|:  .||.::.       :.::|:||                 |:.:......|:
Zfish   438 QLSSSAKY--PECLRRMQPELWSQIRKKKVKNRAVGKEKSNEGGKDRVKHLKAETSVGLTVTRRK 500

  Fly   476 --ICDKCGKQMRTKIILKKHQELMHSDKPRPEPELQQCQICGAWLKGMTGLKQHMKSIHVESAGE 538
              .|:.|.|:..||:.:::|..:...|||                         .|..|
Zfish   501 EFCCNLCDKKFSTKLTMRRHMGIHQGDKP-------------------------FKCPH------ 534

  Fly   539 HRCHICAKVSPNARALRRHIYHNHECERKFKCTMCEKAFKRPQELKEHTSTHTGEVLYTCPNCPM 603
              ||.|.::.   .:|.:|: ..|..|:.:||..|..|......|:.|:.|||.|..|.|..||.
Zfish   535 --CHYCTRLK---ASLIQHL-RIHTGEKPYKCLQCSYASIDRSSLRRHSRTHTQEKPYCCQYCPY 593

  Fly   604 TFFCSANMYKHRQR--------LHRAQYEADKNQ 629
            :......:..|.:|        .|..||.....|
Zfish   594 SSIQKKCLDLHSRRHHTGESFPCHLCQYSTPDRQ 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071	13/55 (24%)
		FYDLN_acid	<191..268	CDD:302856	16/108 (15%)
		C2H2 Zn finger	330..351	CDD:275368	7/20 (35%)
		C2H2 Zn finger	360..378	CDD:275368	0/17 (0%)
		LIM	361..>400	CDD:295319	3/38 (8%)
		C2H2 Zn finger	386..406	CDD:275368	6/19 (32%)
		zf-C2H2_8	389..465	CDD:292531	21/115 (18%)
		C2H2 Zn finger	417..438	CDD:275368	7/20 (35%)
		C2H2 Zn finger	448..465	CDD:275368	5/40 (13%)
		C2H2 Zn finger	477..498	CDD:275368	6/20 (30%)
		C2H2 Zn finger	511..532	CDD:275368	1/20 (5%)
		C2H2 Zn finger	541..562	CDD:275368	5/20 (25%)
		C2H2 Zn finger	570..590	CDD:275368	5/19 (26%)
		C2H2 Zn finger	598..619	CDD:275368	5/28 (18%)
si:dkey-154p10.3	XP_692110.2	C2H2 Zn finger	275..295	CDD:275368	3/19 (16%)
		C2H2 Zn finger	303..323	CDD:275368	2/20 (10%)
		C2H2 Zn finger	334..350	CDD:275368	4/24 (17%)
		COG5048	<500..632	CDD:227381	38/165 (23%)
		C2H2 Zn finger	504..524	CDD:275368	6/19 (32%)
		zf-H2C2_2	517..539	CDD:290200	8/54 (15%)
		C2H2 Zn finger	532..552	CDD:275368	6/31 (19%)
		C2H2 Zn finger	560..580	CDD:275368	5/19 (26%)
		zf-H2C2_2	572..594	CDD:290200	10/21 (48%)
		C2H2 Zn finger	588..608	CDD:275368	4/19 (21%)
		C2H2 Zn finger	616..636	CDD:275368	4/12 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100