DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and Zfp386

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_001004066.1	Gene:	Zfp386 / 56220	MGIID:	1930708	Length:	626	Species:	Mus musculus

Alignment Length:	424	Identity:	105/424 - (24%)
Similarity:	161/424 - (37%)	Gaps:	92/424 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   236 TDPDFSCLVPSDNSSED--------DGGSDGFDSDSDFELDNGKQEFAVLPKRTVVRPKKYKKRT 292
            |||    |:.|.|...|        ...|.||.|.|   |.|...:..:|.|.
Mouse   254 TDP----LLHSQNLDTDIWETPYMYKEISKGFSSGS---LLNSCNDVVILEKS------------ 299

  Fly   293 KPAEPKVRMSRELLEQRKKQQEEYDVIIA----------------KFFT--SVLPCAICNLLVHN 339
                          .||.|.|.::|..::                .|||  |.|....||.:..|
Mouse   300 --------------GQRDKVQNDFDHCLSPNNHQCNLPKKLFNCDNFFTQCSKLTIQQCNYIQDN 350

  Fly   340 ----------FTEMQRHHRLTHQVDPGYMMC--CGRKFTQRKVLAEHVLVHWNPDHFKCSVCEKS 392
                      |.:.....|...|.......|  ||:.|.......:|.::|.....:||.:|.||
Mouse   351 HYKSIDCDTMFNKTLNVTRRKIQHSKKSYKCNECGKAFKYCSSYRKHSIIHTGEKPYKCKLCGKS 415

  Fly   393 FQNSRHLESHQQVHMDPAVKLTFSCDLCSKTFLSKTAIDYHKLNKHVPKSEFKFTCSECNKKFLT 457
            |.....|:.||::|..   :..:.|:.|.::|...:.:..|   :.:...|..:.|.:|.|.|..
Mouse   416 FTQCASLKKHQRIHTG---EKPYRCEECGRSFNHYSILGQH---QRIHTGEKPYKCKQCGKSFTQ 474

  Fly   458 ERKLKNHMSSMHDPESTIICDKCGKQMRTKIILKKHQELMHSDKPRPEPELQQCQICGAWLKGMT 522
            ...|:.| ..:|..|....|.:|||.......|.:||.:...:||      .:|:.||......:
Mouse   475 CSSLQKH-QVIHTGEKPYRCAECGKSFTQNSTLSQHQRIHTGEKP------YKCEECGKAFTQCS 532

  Fly   523 GLKQHMKSIHVESAGE--HRCHICAKVSPNARALRRHIYHNHECERKFKCTMCEKAFKRPQELKE 585
            .|::|.: ||   .||  ::|.:|.:......:..:| ...|..|:.:||..|:|||.....|.:
Mouse   533 SLRKHQR-IH---TGEKPYKCEVCGRAFNCRSSFTKH-KRIHTGEKPYKCKDCDKAFIHCTNLIQ 592

  Fly   586 HTSTHTGEVLYTCPNCPMTFFCSANMYKHRQRLH 619
            |...||||..|.|..|..:|...:|:.|| :|:|
Mouse   593 HQRIHTGEKPYKCNECGKSFSQCSNLRKH-ERIH 625

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856	12/39 (31%)
		C2H2 Zn finger	330..351	CDD:275368	5/30 (17%)
		C2H2 Zn finger	360..378	CDD:275368	5/19 (26%)
		LIM	361..>400	CDD:295319	11/38 (29%)
		C2H2 Zn finger	386..406	CDD:275368	8/19 (42%)
		zf-C2H2_8	389..465	CDD:292531	18/75 (24%)
		C2H2 Zn finger	417..438	CDD:275368	4/20 (20%)
		C2H2 Zn finger	448..465	CDD:275368	5/16 (31%)
		C2H2 Zn finger	477..498	CDD:275368	7/20 (35%)
		C2H2 Zn finger	511..532	CDD:275368	5/20 (25%)
		C2H2 Zn finger	541..562	CDD:275368	3/20 (15%)
		C2H2 Zn finger	570..590	CDD:275368	7/19 (37%)
		C2H2 Zn finger	598..619	CDD:275368	7/20 (35%)
Zfp386	NP_001004066.1	KRAB	6..>46	CDD:214630
		KRAB	6..45	CDD:279668
		C2H2 Zn finger	356..373	CDD:275368	2/16 (13%)
		C2H2 Zn finger	381..401	CDD:275368	5/19 (26%)
		zf-H2C2_2	393..418	CDD:290200	8/24 (33%)
		C2H2 Zn finger	409..429	CDD:275368	8/19 (42%)
		zf-H2C2_2	421..446	CDD:290200	7/27 (26%)
		C2H2 Zn finger	437..457	CDD:275368	4/22 (18%)
		zf-H2C2_2	452..474	CDD:290200	6/24 (25%)
		COG5048	<461..621	CDD:227381	48/171 (28%)
		C2H2 Zn finger	465..485	CDD:275368	6/20 (30%)
		zf-H2C2_2	477..502	CDD:290200	8/25 (32%)
		C2H2 Zn finger	493..513	CDD:275368	7/19 (37%)
		zf-H2C2_2	506..530	CDD:290200	8/29 (28%)
		C2H2 Zn finger	521..541	CDD:275368	5/20 (25%)
		zf-H2C2_2	533..558	CDD:290200	8/28 (29%)
		C2H2 Zn finger	549..569	CDD:275368	3/20 (15%)
		zf-H2C2_2	561..584	CDD:290200	7/23 (30%)
		C2H2 Zn finger	577..597	CDD:275368	7/19 (37%)
		zf-H2C2_2	589..614	CDD:290200	10/24 (42%)
		C2H2 Zn finger	605..625	CDD:275368	7/20 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S12285
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.950