DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and zgc:162972

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_021323880.1	Gene:	zgc:162972 / 558355	ZFINID:	ZDB-GENE-070424-49	Length:	817	Species:	Danio rerio

Alignment Length:	464	Identity:	114/464 - (24%)
Similarity:	173/464 - (37%)	Gaps:	110/464 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   283 VRPKKYKKRTKPAEPKVRMSREL----LEQRKKQQE-----------EYDVIIAKFFTSVLPCAI 332
            ::.|.....|...|.|..:..|:    |:|...::|           |...:..|...:...|..
Zfish   329 LKQKLISHMTVHTEVKPALGIEIVLFTLDQMDIKEEDCVSQSGTHITEQSSLKIKTGETAFTCKQ 393

  Fly   333 CNLLVHNFTEMQ--RHHRLTHQVDPGYMMC--CGRKFTQRKVLAEHVLVHWNPDHFKCSVCEKSF 393
            |..:   ||..|  ..|::.|..:..| .|  ||:.|||.:.|..|:.:|.....|.|..|:|.|
Zfish   394 CGEI---FTTNQSLESHKVIHTGEQHY-FCSECGKSFTQMRYLKNHMKIHAGDHPFTCPECDKCF 454

  Fly   394 QNSRHLESHQQVH--------------------MDPAVKL-----TFSCDLCSKTFLSKTAIDYH 433
            .....||||.::|                    ::..:::     .::|..|.|:|..|..:|.|
Zfish   455 TMKHSLESHLKIHTGEKPFTCPDCGKKFRLKQSLEGHMRIHTGEKPYTCQNCGKSFREKQILDTH 519

  Fly   434 KLNKHVPKSEFKFTCSECNKKFLTERKLKNHMSSMHDPESTIICDKCGKQMRTKIILKKHQELMH 498
             |..|.  .|..::|.||.|.|..::.|:||:.: |..|....|.:|||....|..|::|..:..
Zfish   520 -LTIHT--GEKPYSCPECGKSFRVKKCLENHIKT-HTGEKPYTCQECGKSFAIKQNLERHMRIHT 580

  Fly   499 SDKPRPEPE-------------------------LQQ-------------------------CQI 513
            .:||...||                         .||                         |..
Zfish   581 GEKPYSCPECGRSFRVKQDLKIHVRIHTGEKPFSCQQCGKSFTENKKLESHMRIHTGEKPFVCSH 645

  Fly   514 CGAWLKGMTGLKQHMKSIHVESAGEHRCHICAKVSPNARALRRHIYHNHECERKFKCTMCEKAFK 578
            ||...:|...|:.||: :|..|. .:.|..|.|.....::|..|| ..|..|:.|.|..|.|:|.
Zfish   646 CGKNFRGKQNLESHMR-LHTGSK-PYTCPQCGKSYNQQKSLDIHI-RTHTGEKPFACDQCGKSFT 707

  Fly   579 RPQELKEHTSTHTGEVLYTCPNCPMTFFCSANMYKHRQRLHRAQYEADKNQPKPPNILK----IS 639
            ....||.|...||||..:|||.|..:|.....:.:|: ::|..:...|....|....||    |.
Zfish   708 HQSNLKGHIRIHTGEKPFTCPQCGKSFIEKTKLERHK-KIHSGEKPYDCQHCKKSFTLKQSLDIH 771

  Fly   640 RNASTQNKP 648
            ....|:.||
Zfish   772 MKLHTREKP 780

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856
		C2H2 Zn finger	330..351	CDD:275368	6/22 (27%)
		C2H2 Zn finger	360..378	CDD:275368	8/19 (42%)
		LIM	361..>400	CDD:295319	13/38 (34%)
		C2H2 Zn finger	386..406	CDD:275368	8/19 (42%)
		zf-C2H2_8	389..465	CDD:292531	25/100 (25%)
		C2H2 Zn finger	417..438	CDD:275368	8/20 (40%)
		C2H2 Zn finger	448..465	CDD:275368	7/16 (44%)
		C2H2 Zn finger	477..498	CDD:275368	7/20 (35%)
		C2H2 Zn finger	511..532	CDD:275368	7/20 (35%)
		C2H2 Zn finger	541..562	CDD:275368	6/20 (30%)
		C2H2 Zn finger	570..590	CDD:275368	7/19 (37%)
		C2H2 Zn finger	598..619	CDD:275368	5/20 (25%)
zgc:162972	XP_021323880.1	COG5048	8..328	CDD:227381
		C2H2 Zn finger	12..32	CDD:275368
		C2H2 Zn finger	40..60	CDD:275368
		C2H2 Zn finger	68..88	CDD:275368
		C2H2 Zn finger	96..116	CDD:275368
		C2H2 Zn finger	124..144	CDD:275368
		C2H2 Zn finger	152..172	CDD:275368
		COG5048	176..603	CDD:227381	68/281 (24%)
		C2H2 Zn finger	180..200	CDD:275368
		C2H2 Zn finger	208..228	CDD:275368
		C2H2 Zn finger	236..256	CDD:275368
		C2H2 Zn finger	264..284	CDD:275368
		C2H2 Zn finger	292..312	CDD:275368
		C2H2 Zn finger	320..340	CDD:275368	2/10 (20%)
		C2H2 Zn finger	391..411	CDD:275368	6/22 (27%)
		COG5048	417..799	CDD:227381	97/373 (26%)
		C2H2 Zn finger	419..439	CDD:275368	8/19 (42%)
		C2H2 Zn finger	447..467	CDD:275368	8/19 (42%)
		C2H2 Zn finger	475..495	CDD:275368	0/19 (0%)
		C2H2 Zn finger	503..523	CDD:275368	8/20 (40%)
		C2H2 Zn finger	531..551	CDD:275368	8/20 (40%)
		C2H2 Zn finger	559..579	CDD:275368	7/19 (37%)
		C2H2 Zn finger	587..607	CDD:275368	2/19 (11%)
		C2H2 Zn finger	615..635	CDD:275368	2/19 (11%)
		C2H2 Zn finger	643..663	CDD:275368	7/20 (35%)
		C2H2 Zn finger	671..691	CDD:275368	6/20 (30%)
		C2H2 Zn finger	699..719	CDD:275368	7/19 (37%)
		C2H2 Zn finger	727..747	CDD:275368	5/20 (25%)
		C2H2 Zn finger	755..775	CDD:275368	4/19 (21%)
		C2H2 Zn finger	783..803	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910