DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and ZFP64

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_060667.2	Gene:	ZFP64 / 55734	HGNCID:	15940	Length:	681	Species:	Homo sapiens

Alignment Length:	486	Identity:	105/486 - (21%)
Similarity:	170/486 - (34%)	Gaps:	113/486 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   206 DAAVAPPQKPKEDIQLDLKAEELDEFVDEETDPDFSCLVPSDNSSEDDGGSDGFDSDS------- 263
            ||.||..|...:.......|....:||.|||.|          :::....:....|::
Human    44 DAFVAHKQSGCQLTGTSAAAPSTVQFVSEETVP----------ATQTQTTTRTITSETQTITVSA 98

  Fly   264 -DFELDNGKQEFAVLPKR-------TVVRPKKYKKRTKPAEPKVRMSRELLEQRKKQQEEYDVII 320
             :|..::|.|.:  ||..       ||:......:..||..|..        |::
Human    99 PEFVFEHGYQTY--LPTESNENQTATVISLPAKSRTKKPTTPPA--------QKR---------- 143

  Fly   321 AKFFTSVLPCAI--CNL-LVHNFTEMQRHHRLTHQVDPGYMMCCGRKFTQRKVLAEHVLVHWNPD 382
                   |.|..  |.. ..:...:|:||.::.....|.....||:.|:::..|..|:..|....
Human   144 -------LNCCYPGCQFKTAYGMKDMERHLKIHTGDKPHKCEVCGKCFSRKDKLKTHMRCHTGVK 201

  Fly   383 HFKCSVCEKSFQNSRHLESHQQVHMDPAVKLTFSCDLCSKTFLSKTAIDYHKLNKHVPKSEFKFT 447
            .:||..|:.:..:|..|..|.::|.|   :..|.|.:|.....:.:.:..| |..|.  .:..|.
Human   202 PYKCKTCDYAAADSSSLNKHLRIHSD---ERPFKCQICPYASRNSSQLTVH-LRSHT--GDAPFQ 260

  Fly   448 CSECNKKFLTERKLKNHMSSMHDPESTIICDKCGKQMRTKIILKKHQELMHSDKPRPEPELQQCQ 512
            |..|:.||.....||.|| .:|..|....|:.|..:...|..||.|..:.||......|   .|.
Human   261 CWLCSAKFKISSDLKRHM-RVHSGEKPFKCEFCNVRCTMKGNLKSHIRIKHSGNNFKCP---HCD 321

  Fly   513 ICGAWLKGMTGLKQHMKSIHVESAGEHRCHICAKVSPNARALRRHIYHNHECERKFKCTMCEKAF 577
            ..|   .....|::|.: :| :|....:|..|:....:..|||.| ...|..:|.|||..|....
Human   322 FLG---DSKATLRKHSR-VH-QSEHPEKCSECSYSCSSKAALRIH-ERIHCTDRPFKCNYCSFDT 380

  Fly   578 KRPQELKEHTSTHTGEVLYT--------------------------CPNCPMTFFCSANMYKHRQ 616
            |:|..|.:|.....|:::.|                          |..|..:|....::..|::
Human   381 KQPSNLSKHMKKFHGDMVKTEALERKDTGRQSSRQVAKLDAKKSFHCDICDASFMREDSLRSHKR 445

  Fly   617 RLHRAQYEADKN--------------QPKPP 633
            :  .::|...||              ||..|
Human   446 Q--HSEYSESKNSDVTVLQFQIDPSKQPATP 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856	14/69 (20%)
		C2H2 Zn finger	330..351	CDD:275368	5/23 (22%)
		C2H2 Zn finger	360..378	CDD:275368	5/17 (29%)
		LIM	361..>400	CDD:295319	10/38 (26%)
		C2H2 Zn finger	386..406	CDD:275368	5/19 (26%)
		zf-C2H2_8	389..465	CDD:292531	19/75 (25%)
		C2H2 Zn finger	417..438	CDD:275368	4/20 (20%)
		C2H2 Zn finger	448..465	CDD:275368	6/16 (38%)
		C2H2 Zn finger	477..498	CDD:275368	6/20 (30%)
		C2H2 Zn finger	511..532	CDD:275368	4/20 (20%)
		C2H2 Zn finger	541..562	CDD:275368	6/20 (30%)
		C2H2 Zn finger	570..590	CDD:275368	6/19 (32%)
		C2H2 Zn finger	598..619	CDD:275368	4/20 (20%)
ZFP64	NP_060667.2	COG5048	<151..450	CDD:227381	73/316 (23%)
		zf-H2C2_2	161..186	CDD:290200	7/24 (29%)
		C2H2 Zn finger	177..197	CDD:275368	5/19 (26%)
		zf-H2C2_2	190..211	CDD:290200	6/20 (30%)
		C2H2 Zn finger	205..225	CDD:275368	5/19 (26%)
		zf-H2C2_2	217..239	CDD:290200	7/24 (29%)
		C2H2 Zn finger	233..253	CDD:275368	4/20 (20%)
		C2H2 Zn finger	261..281	CDD:275368	8/20 (40%)
		zf-H2C2_2	273..297	CDD:290200	8/24 (33%)
		C2H2 Zn finger	289..308	CDD:275368	6/18 (33%)
		C2H2 Zn finger	373..391	CDD:275368	6/17 (35%)
		zf-C2H2_6	425..450	CDD:290623	4/26 (15%)
		C2H2 Zn finger	427..447	CDD:275368	4/21 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144323
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.030