DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and ZNF407

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_001371404.1	Gene:	ZNF407 / 55628	HGNCID:	19904	Length:	2248	Species:	Homo sapiens

Alignment Length:	752	Identity:	151/752 - (20%)
Similarity:	236/752 - (31%)	Gaps:	258/752 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 TIVNQHFPVQISK----------ESDERICGRCWKIVSDFHTLHEFVSAAQSSLQETKVALMEDD 90
            :|:|::..:.:||          |::|.         |:|:..|.|....|.:..:.||...|
Human  1128 SILNENTNLDMSKVLCAADSVEVETEEE---------SNFNEDHSFCETFQQAPVKDKVRKPE-- 1181

  Fly    91 PLTQETTSFPEIIKLATQEEEGVTE--PQELGGRNFFYPEIKIEEHELD---------------- 137
                      |::.|......|...  ..|..|.:....|...:.||:.
Human  1182 ----------EMMSLTMSSNYGSPSRFQNENSGSSALNCETAKKNHEISNDAGELRVHCEGEGGN 1236

  Fly   138 ------TLPRIEIL------ERSAN---------TQENQDQLEGAARRLRKRLKAEDGSSVDKDK 181
                  .:|...:.      ||||.         |:|..:...|...|:.:....||...|.:|
Human  1237 AGDGGGVVPHRHLCPVTLDGERSAESPVLVVTRITREQGNLESGGQNRVARGHGLEDLKGVQED- 1300

  Fly   182 DEDGVEETAEPAPPKKRRGRPRKSDAAVAPPQKPKEDIQLDLKAEELDEFVDEETDPDFSCLVPS 246
                                          |....::|.::.:.|  .||:.||..|.....|.|
Human  1301 ------------------------------PVLGNKEILMNSQHE--TEFILEEDGPASDSTVES 1333

  Fly   247 DNSSE-----DDGG----SDG-FDSD-------SDFELDNGKQE--------FAVLPKRTV---V 283
            .:..|     ||.|    |.| |||.       .|.||.:..:|        .:.||.:..   |
Human  1334 SDVYETIISIDDKGQAMYSFGRFDSSIIRIKNPEDGELIDQSEEGLIATGVRISELPLKDCAQGV 1398

  Fly   284 RPKKYKKRTKPAEPKVR-------------MSRELLEQRKKQQEEYDVIIA--KFFT-------- 325
            :.||.:..:.....::|             ::..:..:...:::.:..::.  .|:|
Human  1399 KKKKSEGSSIGESTRIRCDDCGFLADGLSGLNVHIAMKHPTKEKHFHCLLCGKSFYTESNLHQHL 1463

  Fly   326 --------------------SVLPCAIC--------NLLVHNFTEMQRHHRLTHQVDPGYM---- 358
                                :...|..|        ||.:|   ...:|..|..:|:. |:
Human  1464 ASAGHMRNEQASVEELPEGGATFKCVKCTEPFDSEQNLFLH---IKGQHEELLREVNK-YIVEDT 1524

  Fly   359 -------------MC--CGRKFTQRKVLA--EHVLVHWNPDHFKCSVCEKSFQNSRHLESHQQVH 406
                         :|  ||:.......:|  .|:..|.....|||.:|..:........:|.:.|
Human  1525 EQINREREENQGNVCKYCGKMCRSSNSMAFLAHIRTHTGSKPFKCKICHFATAQLGDARNHVKRH 1589

  Fly   407 MDPAVKLTFSCDLCSKTFLSKTAIDYHKLNKH---VPKSEFKFTCSECNKKFLTERKLKNHMSSM 468
            :.   ...:.|.:|...|:.|..::.|.|.||   .|| |.||||..|::.|..:..|.||| .:
Human  1590 LG---MREYKCHVCGVAFVMKKHLNTHLLGKHGVGTPK-ERKFTCHLCDRSFTEKWALNNHM-KL 1649

  Fly   469 HDPESTIIC--DKCGKQMRTKIILKKHQELMHSDKPRPEPELQQCQICGAWLKGMTGLKQHMKSI 531
            |..|....|  ..|.....|...:|.|                        .:..||.|..:
Human  1650 HTGEKPFKCTWPTCHYSFLTASAMKDH------------------------YRTHTGEKSFL--- 1687

  Fly   532 HVESAGEHRCHICAKVSPNARALRRHIYHNHECERKFKCTMCEKAFKRPQELKEHTSTHTGEVLY 596
                     |.:|........||.:| ...|..|:.|||..|..|......|..|...||||..|
Human  1688 ---------CDLCGFAGGTRHALTKH-RRQHTGEKPFKCDECNFASTTQSHLTRHKRVHTGEKPY 1742

  Fly   597 TCPNCPMTFFCSANMYKHRQRLHRAQYEADK--NQPK 631
            .||.|.....|:.|:.||  .||..::|..|  |.||
Human  1743 RCPWCDYRSNCAENIRKH--ILHTGKHEGVKMYNCPK 1777

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071	11/54 (20%)
		FYDLN_acid	<191..268	CDD:302856	21/93 (23%)
		C2H2 Zn finger	330..351	CDD:275368	7/28 (25%)
		C2H2 Zn finger	360..378	CDD:275368	5/21 (24%)
		LIM	361..>400	CDD:295319	9/40 (23%)
		C2H2 Zn finger	386..406	CDD:275368	3/19 (16%)
		zf-C2H2_8	389..465	CDD:292531	22/78 (28%)
		C2H2 Zn finger	417..438	CDD:275368	6/20 (30%)
		C2H2 Zn finger	448..465	CDD:275368	5/16 (31%)
		C2H2 Zn finger	477..498	CDD:275368	5/22 (23%)
		C2H2 Zn finger	511..532	CDD:275368	3/20 (15%)
		C2H2 Zn finger	541..562	CDD:275368	5/20 (25%)
		C2H2 Zn finger	570..590	CDD:275368	5/19 (26%)
		C2H2 Zn finger	598..619	CDD:275368	7/20 (35%)
ZNF407	NP_001371404.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..84
		C2H2 Zn finger	188..208	CDD:275368
		C2H2 Zn finger	217..238	CDD:275368
		C2H2 Zn finger	246..268	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	291..322
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	494..515
		C2H2 Zn finger	590..614	CDD:275371
		C2H2 Zn finger	617..639	CDD:275371
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	667..700
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	821..847
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	910..962
		C2H2 Zn finger	1416..1445	CDD:275371	0/28 (0%)
		C2H2 Zn finger	1446..1468	CDD:275371	2/21 (10%)
		C2H2 Zn finger	1488..1509	CDD:275371	5/23 (22%)
		C2H2 Zn finger	1539..1561	CDD:275368	5/21 (24%)
		zf-H2C2_2	1557..1578	CDD:404364	6/20 (30%)
		C2H2 Zn finger	1569..1589	CDD:275368	3/19 (16%)
		C2H2 Zn finger	1597..1617	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1630..1650	CDD:275368	7/20 (35%)
		zf-H2C2_2	1642..1669	CDD:404364	8/27 (30%)
		C2H2 Zn finger	1658..1680	CDD:275368	5/45 (11%)
		C2H2 Zn finger	1688..1708	CDD:275368	5/20 (25%)
		zf-H2C2_2	1700..1725	CDD:404364	10/25 (40%)
		zf-H2C2_5	1714..1738	CDD:404746	8/23 (35%)
		C2H2 Zn finger	1716..1736	CDD:275368	5/19 (26%)
		zf-H2C2_2	1728..1753	CDD:404364	10/24 (42%)
		C2H2 Zn finger	1744..1761	CDD:275368	7/18 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100