DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and zfp91

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_021326898.1	Gene:	zfp91 / 555616	ZFINID:	ZDB-GENE-090313-11	Length:	792	Species:	Danio rerio

Alignment Length:	728	Identity:	145/728 - (19%)
Similarity:	244/728 - (33%)	Gaps:	235/728 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 SSLQETKVALMEDDPLTQETTSFPEIIKLATQEEEG-----VTEPQEL---------GGRNFFYP 127
            |:.:||:.....:....|.|.|.|  .:.:....:|     ||.|.|.         .||
Zfish     7 SNKEETESETAIEKSAGQSTASSP--CRASRGRGDGCFNTEVTCPPETNGAATSATGSGR----- 64

  Fly   128 EIKIEEHELDTLPRIEILERSANTQENQDQLEGAARR-----LRKRLKAEDGSSVDKDKDEDG-- 185
              .:.:....|:|.....:.|.:..|......|..||     .|::..|...:|.|..||..|
Zfish    65 --VLRDRSTRTIPVWRQTDISEDLAEVSRDASGNRRRKAKCPRRRKSPAAAAASSDAGKDSGGDC 127

  Fly   186 -----VEETAEPAPPKKRRGR--------------PR---KSD----------------AAVAPP 212
                 .||..:....:..|||              ||   ||:                ...:..
Zfish   128 DLLDEFEENKDALVNRAARGRRVQVRSGARTCRGSPRTVFKSEPEMDVDYVEANKAVEKTGTSVE 192

  Fly   213 QKPKEDIQLDLKAEELDEFVDEETDPDF---SCLVPS-----------DNSSEDD---------- 253
            :|.:|.:..|:..||...|||:..|.::   |..:||           |:||:.|
Zfish   193 KKEEESMDDDVVEEEECPFVDDPKDENYRPQSNRIPSVRRQDKHSTMTDSSSDSDEAESSSQIPH 257

  Fly   254 GGSDGFDSDSD--FELDNGKQ-----EFAVLPKRTVVRPKKYKKRTKP----------------- 294
            .|.:...||.|  |..|...|     :|:...:|...|.|  :|:.||
Zfish   258 EGEETISSDEDVPFRDDLNDQSYDPKDFSKSKRRPHTRLK--EKKDKPTVQETPTEQETEIKTEG 320

  Fly   295 ---------------AEPKVRMSR--------ELLEQRKKQQEEYDVIIAKFFTSVLPCAI--CN 334
                           |||..:..|        .|.::|||...:|           :.|.:  |.
Zfish   321 GETTEEQTRAEVEEGAEPPRKRGRRRKDDKSPRLPKRRKKPPVQY-----------VRCEMEGCG 374

  Fly   335 LLVHNFTEMQRHHRLTHQVDPGYMMC----CGRKFTQRKVLAEHVLVHWNPDHFKCSVCEKSFQN 395
            .::.:...:|.|.:..|.:...| :|    |||.|..:|.|..|...|.:...:.|..|.::|::
Zfish   375 TVLAHPRYLQHHIKYQHLMKKKY-VCPHPTCGRLFRLQKQLLRHAKHHTDQRDYICEFCARAFKS 438

  Fly   396 SRHLESHQQVHMDPAVKLTFSCDLCSKTFLSKTAIDYHKLNKHVPKSEFKFTCSECNKKFLTERK 460
            |.:|..|:.:|..   :....|::|..|...|.::::| :.||...:.::|:||.|.|||
Zfish   439 SHNLAVHRMIHTG---EKPLQCEICGFTCRQKASLNWH-MKKHDADATYQFSCSICGKKF----- 494

  Fly   461 LKNHMSSMHDPESTIICDKCGKQMRTKIILKKHQELMHSDKPRPEPELQQCQICGA--------- 516
                                         .||...:.|..|..||..:.:.....|
Zfish   495 -----------------------------EKKDSVVAHKAKSHPEVLIAEALAANAGALITTPAG 530

  Fly   517 ---WLKGMTGLKQHMKSIHVESAGEH-----RCHICAKVSPNARALRRHIYHNHECERKFKCTMC 573
               .|:..||..|..:.:. |:.|..     :......|.|.....:.|..|:    .:...|:.
Zfish   531 VTTLLETNTGSGQTEQGVS-ETRGSSTVPAGQVAPVTHVGPVMVVDQNHPLHS----MQVPVTLA 590

  Fly   574 EKAFKRPQELKEHTSTHTGEVLYTCPNCPMTFFCSANMYKHRQRLHRAQYEADKNQPKPPNILKI 638
            ..:.:......:.||:|:.::       |:.|..|....:.:|::        :..|..|::..|
Zfish   591 LSSTEENNTPLQQTSSHSLQM-------PLQFVSSPVSQQQQQQI--------QQHPLHPSVTSI 640

  Fly   639 SRNAS-TQNKPKQ 650
            |:.|: .|..|.|
Zfish   641 SQQATLVQQLPVQ 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071	1/3 (33%)
		FYDLN_acid	<191..268	CDD:302856	28/135 (21%)
		C2H2 Zn finger	330..351	CDD:275368	4/22 (18%)
		C2H2 Zn finger	360..378	CDD:275368	8/21 (38%)
		LIM	361..>400	CDD:295319	12/38 (32%)
		C2H2 Zn finger	386..406	CDD:275368	6/19 (32%)
		zf-C2H2_8	389..465	CDD:292531	20/75 (27%)
		C2H2 Zn finger	417..438	CDD:275368	5/20 (25%)
		C2H2 Zn finger	448..465	CDD:275368	6/16 (38%)
		C2H2 Zn finger	477..498	CDD:275368	2/20 (10%)
		C2H2 Zn finger	511..532	CDD:275368	5/32 (16%)
		C2H2 Zn finger	541..562	CDD:275368	4/20 (20%)
		C2H2 Zn finger	570..590	CDD:275368	3/19 (16%)
		C2H2 Zn finger	598..619	CDD:275368	4/20 (20%)
zfp91	XP_021326898.1	zf-C2H2_8	368..445	CDD:318181	20/77 (26%)
		C2H2 Zn finger	402..421	CDD:275368	7/18 (39%)
		C2H2 Zn finger	429..449	CDD:275368	6/19 (32%)
		zf-C2H2	456..477	CDD:306579	5/21 (24%)
		C2H2 Zn finger	457..477	CDD:275368	5/20 (25%)
		C2H2 Zn finger	487..503	CDD:275368	8/49 (16%)
		Amelogenin	<633..>716	CDD:330537	7/21 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100