DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and zbtb40

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_002937082.3	Gene:	zbtb40 / 548670	XenbaseID:	XB-GENE-967576	Length:	1352	Species:	Xenopus tropicalis

Alignment Length:	774	Identity:	159/774 - (20%)
Similarity:	257/774 - (33%)	Gaps:	254/774 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 VTTIVN------QHFPVQISKESDERICGRCWKIVSDFHTLHEFVSAAQSSLQETKVALMEDDP- 91
            :||.||      :.....:.|.:..:|......:|.|..||      |.::|....:|:.|.:|
Frog   595 ITTTVNLTTHEREVMEQVVKKNTTSKIFSTLVSMVLDEQTL------AVTALWLLLLAMQESNPS 653

  Fly    92 ---LTQETTS-------FPEIIKLATQEEEGVTEPQELGGRNFFYPEIKIEEHELDTLPRIE--- 143
               |.:|...       |..:|....:..|.:....||..:.|...:|      |..:|..|
Frog   654 LKSLMEEIRKEPGAEVFFQSVINRGNEAAEVLVRHNELIAQAFGQCDI------LSYVPSKETAL 712

  Fly   144 ---ILERSANTQENQDQ---------------------------LEGAARRLR---KRLKAEDGS 175
               :.|.....|:|:|.                           ::|::..|:   |.|| :.|.
Frog   713 TDLVKELLKVPQQNEDSELPSKMLLSAALQHTVPAMSFCSLLFTVQGSSPHLQPVIKELK-QIGI 776

  Fly   176 SVDKDKDEDGVEETAEPAPPKKRRGRPRKSDAAVAPPQKPKEDIQLDLKAEELDEFVDEETDPDF 240
            .::.::...||..                        .....:.|| :.||:..|..|||....:
Frog   777 LMEGEESFQGVSR------------------------WNVNSECQL-VVAEDSAEGNDEEEQTKY 816

  Fly   241 SCLVPSDNSSEDDGGSDGFDSDSDFELDNGKQEFAVLPKRTVVRPKKYKKRTKPAEPKVRMSREL 305
                    ...:||.|.....||..|..:.|:.|.                .|..: |:.:.|..
Frog   817 --------DENEDGDSSKESKDSVQEKGSSKKNFI----------------CKSCD-KIFLFRCR 856

  Fly   306 LEQRKKQQEEYDVIIAKFFTSVLPCAICNLLVHNFTEMQRHHRLTHQVDPGYMM----------- 359
            ||...|:..     :||  .:.|.|..||.:..:..|:.:|....|    ||::
Frog   857 LEVHMKRCR-----MAK--RNPLQCKDCNEIQSSRKELDQHREAVH----GYLVSSRTNKGRRRL 910

  Fly   360 ---C--CGRKFTQRKVLAEHVLV-HWNPDHFKCSVCEKSFQNSRHLESHQQVHMDPAVKLTFSCD 418
               |  ||::|.....|..|... |::...|.|..|...|..:..|::||::|..   :..|.|.
Frog   911 LVTCDICGKEFAHPSGLQYHKRTEHFDEKPFSCDECGAKFAANSTLKNHQRLHTG---ERPFVCK 972

  Fly   419 LCSKTFLSKTAIDYHKLNKHVPKSEFK-----------------------------FTCSECNKK 454
            .|..||....|:.||...||   ||.|                             :.|.||.|.
Frog   973 HCHMTFTQAAALSYHTKKKH---SEGKMYACQYCDAVFAQSIELTRHVRTHTGDKPYVCRECGKG 1034

  Fly   455 FLTERKLKNHMSSMHDPESTIICDKCGKQMRTKIILKKHQELMHSDKPRPEPELQQ--------- 510
            |.....|..|:.:.|:.|....|.||.....|....::|.:::||.:..|.|...:
Frog  1035 FSQANGLSIHLRTFHNIEDPYDCQKCRMSFPTLEENRQHIQVVHSKEYHPCPTCDKIFSAPSLLE 1099

  Fly   511 -------------CQICGAWLKGMTGLKQHMKSIHVE--SAGEHR-------CHICAKVSPNARA 553
                         |:||....:.::||..|.::.|.:  :|..||       |..|.:..|||..
Frog  1100 RHVVTHVGGKPYNCEICDKAYQQLSGLWYHNRTHHPDLFAAQNHRSSKFSTQCSSCDQTFPNAAL 1164

  Fly   554 LRRHIYHNH------ECER-----------------------KFKCTMCEKAFKRPQELKEHTST 589
            |::|....|      ||::                       .|:|..|..:|:.|..|:.|.:|
Frog  1165 LQKHTKAEHPDGKVYECDKCKQTYPTSAALQVHIKCKHSGTQPFQCLYCTDSFQFPGALQHHVAT 1229

  Fly   590 ---HTGEVLYTCPNCPMTFFCSANMYKHRQRLHRAQYEADKNQPKPPNILKISRNASTQ 645
               |..:..:.|..|...|...:.:.:|        ||.|    .|..:|..::.|.||
Frog  1230 EHFHESDNTFGCEICGELFTVHSQLERH--------YETD----HPEVVLTENQAADTQ 1276

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071	12/52 (23%)
		FYDLN_acid	<191..268	CDD:302856	14/76 (18%)
		C2H2 Zn finger	330..351	CDD:275368	5/20 (25%)
		C2H2 Zn finger	360..378	CDD:275368	6/20 (30%)
		LIM	361..>400	CDD:295319	10/39 (26%)
		C2H2 Zn finger	386..406	CDD:275368	6/19 (32%)
		zf-C2H2_8	389..465	CDD:292531	25/104 (24%)
		C2H2 Zn finger	417..438	CDD:275368	7/20 (35%)
		C2H2 Zn finger	448..465	CDD:275368	6/16 (38%)
		C2H2 Zn finger	477..498	CDD:275368	5/20 (25%)
		C2H2 Zn finger	511..532	CDD:275368	6/20 (30%)
		C2H2 Zn finger	541..562	CDD:275368	7/20 (35%)
		C2H2 Zn finger	570..590	CDD:275368	7/22 (32%)
		C2H2 Zn finger	598..619	CDD:275368	4/20 (20%)
zbtb40	XP_002937082.3	BTB_POZ_ZBTB40	1..116	CDD:349534
		C2H2 Zn finger	874..904	CDD:275368	8/33 (24%)
		COG5048	<913..1075	CDD:227381	42/167 (25%)
		C2H2 Zn finger	914..935	CDD:275368	6/20 (30%)
		C2H2 Zn finger	943..963	CDD:275368	6/19 (32%)
		C2H2 Zn finger	971..1020	CDD:275368	12/51 (24%)
		zf-H2C2_2	1012..1037	CDD:404364	5/24 (21%)
		SFP1	<1022..1136	CDD:227516	25/113 (22%)
		C2H2 Zn finger	1028..1047	CDD:275368	7/18 (39%)
		C2H2 Zn finger	1057..1078	CDD:275370	5/20 (25%)
		C2H2 Zn finger	1085..1104	CDD:275368	1/18 (6%)
		SFP1	<1106..1173	CDD:227516	17/66 (26%)
		C2H2 Zn finger	1113..1133	CDD:275368	6/19 (32%)
		zf-C2H2_8	1152..1233	CDD:406359	18/80 (23%)
		C2H2 Zn finger	1152..1170	CDD:275368	7/17 (41%)
		C2H2 Zn finger	1181..1202	CDD:275368	1/20 (5%)
		C2H2 Zn finger	1210..1229	CDD:275368	6/18 (33%)
		C2H2 Zn finger	1241..1257	CDD:275368	3/15 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910