DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and Plagl2

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_061277.2	Gene:	Plagl2 / 54711	MGIID:	1933165	Length:	496	Species:	Mus musculus

Alignment Length:	279	Identity:	65/279 - (23%)
Similarity:	119/279 - (42%)	Gaps:	58/279 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   385 KCSVCEKSFQNSRHLESHQQVHMDPAVKLTFSCDL--CSKTFLSKTAIDYHKLNKHVP--KSEFK 445
            :|.:....|.|...|..|...|.:   :..:||..  |.|.|.||     :||.:|:.  .::..
Mouse    41 QCEISGTPFSNGEKLRPHSLPHPE---QRPYSCPQLHCGKAFASK-----YKLYRHMATHSAQKP 97

  Fly   446 FTCSECNKKFLTERKLKNHMSSMHDP-ESTIICDKCGKQMRTKIILKKHQELMHSDKPRPEPELQ 509
            ..|..|:|.|..:..|:||:.: ||| :..:.|.:|||...||:
Mouse    98 HQCMYCDKMFHRKDHLRNHLQT-HDPNKEALHCSECGKNYNTKL--------------------- 140

  Fly   510 QCQICGAWLKGMTGLKQHMKSIHVESAGEHRCHICAKVSPNARALRRHI-YHNHEC-----ERKF 568
                         |.::|: ::|..|:|:..|.:|.:...:.:||..|: .|:...     |:|.
Mouse   141 -------------GYRRHL-AMHAASSGDLSCKVCLQTFESTQALLEHLKAHSRRVAGGAKEKKH 191

  Fly   569 KCTMCEKAFKRPQELKEHTSTHTGEVLYTCPNCPMTFFCSANMYKHRQRLHRAQYEADKNQPKPP 633
            .|..|::.|...::::.|...|||...:.|..|...|....::.:|.::.|  ..|..|.:.:|.
Mouse   192 PCDHCDRRFYTRKDVRRHLVVHTGRKDFLCQYCAQRFGRKDHLTRHVKKSH--SQELLKIKTEPV 254

  Fly   634 NILKISRNASTQNKPKQEI 652
            ::|.:...:||.: .|:|:
Mouse   255 DMLGLLSCSSTVS-VKEEL 272

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856
		C2H2 Zn finger	330..351	CDD:275368
		C2H2 Zn finger	360..378	CDD:275368
		LIM	361..>400	CDD:295319	3/14 (21%)
		C2H2 Zn finger	386..406	CDD:275368	5/19 (26%)
		zf-C2H2_8	389..465	CDD:292531	21/79 (27%)
		C2H2 Zn finger	417..438	CDD:275368	8/22 (36%)
		C2H2 Zn finger	448..465	CDD:275368	6/16 (38%)
		C2H2 Zn finger	477..498	CDD:275368	6/20 (30%)
		C2H2 Zn finger	511..532	CDD:275368	2/20 (10%)
		C2H2 Zn finger	541..562	CDD:275368	6/21 (29%)
		C2H2 Zn finger	570..590	CDD:275368	4/19 (21%)
		C2H2 Zn finger	598..619	CDD:275368	4/20 (20%)
Plagl2	NP_061277.2	C2H2 Zn finger	42..62	CDD:275368	5/19 (26%)
		C2H2 Zn finger	70..92	CDD:275368	9/26 (35%)
		zf-H2C2_2	85..109	CDD:372612	6/23 (26%)
		C2H2 Zn finger	100..120	CDD:275368	7/20 (35%)
		C2H2 Zn finger	129..149	CDD:275368	8/54 (15%)
		C2H2 Zn finger	158..178	CDD:275368	5/19 (26%)
		C2H2 Zn finger	193..213	CDD:275368	4/19 (21%)
		C2H2 Zn finger	221..239	CDD:275368	4/17 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910