DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and PLAGL2

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_002648.1	Gene:	PLAGL2 / 5326	HGNCID:	9047	Length:	496	Species:	Homo sapiens

Alignment Length:	281	Identity:	66/281 - (23%)
Similarity:	118/281 - (41%)	Gaps:	62/281 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   385 KCSVCEKSFQNSRHLESHQ--QVHMDPAVKLTFSCDL--CSKTFLSKTAIDYHKLNKHVP--KSE 443
            :|.:....|.|...|..|.  |....|     :||..  |.|.|.||     :||.:|:.  .::
Human    41 QCEISGTPFSNGEKLRPHSLPQPEQRP-----YSCPQLHCGKAFASK-----YKLYRHMATHSAQ 95

  Fly   444 FKFTCSECNKKFLTERKLKNHMSSMHDP-ESTIICDKCGKQMRTKIILKKHQELMHSDKPRPEPE 507
            ....|..|:|.|..:..|:||:.: ||| :..:.|.:|||...||:
Human    96 KPHQCMYCDKMFHRKDHLRNHLQT-HDPNKEALHCSECGKNYNTKL------------------- 140

  Fly   508 LQQCQICGAWLKGMTGLKQHMKSIHVESAGEHRCHICAKVSPNARALRRHI-YHNHEC-----ER 566
                           |.::|: ::|..|:|:..|.:|.:...:.:||..|: .|:...     |:
Human   141 ---------------GYRRHL-AMHAASSGDLSCKVCLQTFESTQALLEHLKAHSRRVAGGAKEK 189

  Fly   567 KFKCTMCEKAFKRPQELKEHTSTHTGEVLYTCPNCPMTFFCSANMYKHRQRLHRAQYEADKNQPK 631
            |..|..|::.|...::::.|...|||...:.|..|...|....::.:|.::.|  ..|..|.:.:
Human   190 KHPCDHCDRRFYTRKDVRRHLVVHTGRKDFLCQYCAQRFGRKDHLTRHVKKSH--SQELLKIKTE 252

  Fly   632 PPNILKISRNASTQNKPKQEI 652
            |.::|.:...:||.: .|:|:
Human   253 PVDMLGLLSCSSTVS-VKEEL 272

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856
		C2H2 Zn finger	330..351	CDD:275368
		C2H2 Zn finger	360..378	CDD:275368
		LIM	361..>400	CDD:295319	3/14 (21%)
		C2H2 Zn finger	386..406	CDD:275368	6/21 (29%)
		zf-C2H2_8	389..465	CDD:292531	22/81 (27%)
		C2H2 Zn finger	417..438	CDD:275368	8/22 (36%)
		C2H2 Zn finger	448..465	CDD:275368	6/16 (38%)
		C2H2 Zn finger	477..498	CDD:275368	6/20 (30%)
		C2H2 Zn finger	511..532	CDD:275368	2/20 (10%)
		C2H2 Zn finger	541..562	CDD:275368	6/21 (29%)
		C2H2 Zn finger	570..590	CDD:275368	4/19 (21%)
		C2H2 Zn finger	598..619	CDD:275368	4/20 (20%)
PLAGL2	NP_002648.1	C2H2 Zn finger	70..92	CDD:275368	9/26 (35%)
		zf-H2C2_2	85..109	CDD:404364	6/23 (26%)
		C2H2 Zn finger	100..120	CDD:275368	7/20 (35%)
		C2H2 Zn finger	129..149	CDD:275368	8/54 (15%)
		C2H2 Zn finger	158..178	CDD:275368	5/19 (26%)
		C2H2 Zn finger	193..213	CDD:275368	4/19 (21%)
		C2H2 Zn finger	221..239	CDD:275368	4/17 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910