DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and znf971

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_001013364.2	Gene:	znf971 / 503768	ZFINID:	ZDB-GENE-050306-52	Length:	406	Species:	Danio rerio

Alignment Length:	470	Identity:	119/470 - (25%)
Similarity:	184/470 - (39%)	Gaps:	86/470 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   170 KAEDGSSVD----KDKDEDGVEETAEPAPPKKRRGRPRKSDAAVAPPQ-----KPKEDIQLDLKA 225
            ::||....|    |.:|.:..|||.          |.:..|    |.|     :||::.::..|.
Zfish     7 ESEDIRIADVFTLKQEDPERTEETF----------RVKHED----PEQLTELIEPKQETEVPNKL 57

  Fly   226 EELDEFVDEETDPDFSCLVPSDNSSEDDGGSDGFDSDSDFELDNGKQEFAVLPKRTVVRPKKYKK 290
            ||.|::.   :..||:....|.:|||.:..|    |....:.:.|...|..        .:..:.
Zfish    58 EENDQYT---SHLDFNTEEQSLSSSETEKTS----SQKRAQKNKGANSFTC--------QECGRS 107

  Fly   291 RTKPAEPKVRMSRELLEQRKKQQEEYDVIIAKFFTSVLP--CAICNLLVHNFTEMQRHHRLTHQV 353
            .::....||.|                    :..|...|  |..|.......|.:..|.| ||..
Zfish   108 FSQSGTLKVHM--------------------RIHTGEKPYSCQQCGKTFRQSTTLNVHMR-THTG 151

  Fly   354 DPGYMMC--CGRKFTQRKVLAEHVLVHWNPDHFKCSVCEKSFQNSRHLESHQQVHMDPAVKLTFS 416
            ...| .|  ||:.|:.|.....|:.||.....:.||.|||||..:..|:.|.:||..   :..|:
Zfish   152 GKPY-SCQQCGKSFSHRLSFTMHMRVHTGEKPYPCSQCEKSFNRNSDLQLHMRVHTG---EKPFT 212

  Fly   417 CDLCSKTFLSKTAIDYHKLNKHVPKSEFKFTCSECNKKFLTERKLKNHMSSMHDPESTIICDKCG 481
            |..|.|.|..|..:..| :..|.  .|..|||..|...|..:...|.|: .:|:.|....|::||
Zfish   213 CQQCGKGFTRKGTLKDH-MTTHT--QEKLFTCKTCGITFTQKEIFKIHI-VIHNSEKPFTCNQCG 273

  Fly   482 KQMRTKIILKKHQELMHSDKPRPEPELQQCQICGAWLKGMTGLKQHMKSIHVESAGE--HRCHIC 544
            |....:...|.|:....::|..|      |..||...:.....:.||::    ..||  :.|..|
Zfish   274 KSFDQEEKFKLHKRFHSAEKHFP------CSHCGKTFRQKQHFEDHMRT----HTGEEVYACPHC 328

  Fly   545 AKVSPNARALRRHI-YHNHECERKFKCTMCEKAFKRPQELKEHTSTHTGEVLYTCPNCPMTFFCS 608
            .:.......|..|| .||.| :|:|.|..|.|:|.:..||..|...||||..::|.:|..:|..:
Zfish   329 ERSFSFKYRLDDHIRIHNRE-KREFPCDQCGKSFSQKSELNRHMRVHTGEKPFSCGHCGKSFKHN 392

  Fly   609 ANMYKHRQRLHRAQY 623
            :.: |:....|:..:
Zfish   393 SGL-KYHMNSHKCTH 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856	18/81 (22%)
		C2H2 Zn finger	330..351	CDD:275368	5/20 (25%)
		C2H2 Zn finger	360..378	CDD:275368	6/19 (32%)
		LIM	361..>400	CDD:295319	14/38 (37%)
		C2H2 Zn finger	386..406	CDD:275368	9/19 (47%)
		zf-C2H2_8	389..465	CDD:292531	24/75 (32%)
		C2H2 Zn finger	417..438	CDD:275368	6/20 (30%)
		C2H2 Zn finger	448..465	CDD:275368	4/16 (25%)
		C2H2 Zn finger	477..498	CDD:275368	6/20 (30%)
		C2H2 Zn finger	511..532	CDD:275368	5/20 (25%)
		C2H2 Zn finger	541..562	CDD:275368	6/21 (29%)
		C2H2 Zn finger	570..590	CDD:275368	7/19 (37%)
		C2H2 Zn finger	598..619	CDD:275368	4/20 (20%)
znf971	NP_001013364.2	COG5048	97..>402	CDD:227381	91/353 (26%)
		C2H2 Zn finger	101..121	CDD:275368	3/47 (6%)
		zf-H2C2_2	114..138	CDD:290200	7/43 (16%)
		C2H2 Zn finger	129..149	CDD:275368	5/20 (25%)
		zf-H2C2_2	142..166	CDD:290200	9/25 (36%)
		C2H2 Zn finger	157..177	CDD:275368	6/19 (32%)
		zf-H2C2_2	169..194	CDD:290200	10/24 (42%)
		C2H2 Zn finger	185..205	CDD:275368	9/19 (47%)
		zf-H2C2_2	197..222	CDD:290200	9/27 (33%)
		C2H2 Zn finger	213..233	CDD:275368	6/20 (30%)
		C2H2 Zn finger	241..261	CDD:275368	5/20 (25%)
		C2H2 Zn finger	269..289	CDD:275368	6/19 (32%)
		C2H2 Zn finger	297..317	CDD:275368	5/23 (22%)
		C2H2 Zn finger	325..345	CDD:275368	5/19 (26%)
		zf-C2H2	352..374	CDD:278523	8/21 (38%)
		C2H2 Zn finger	354..374	CDD:275368	7/19 (37%)
		zf-H2C2_2	366..391	CDD:290200	10/24 (42%)
		C2H2 Zn finger	382..402	CDD:275368	4/20 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910