DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and prdm1

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_002937203.1	Gene:	prdm1 / 493207	XenbaseID:	XB-GENE-853254	Length:	784	Species:	Xenopus tropicalis

Alignment Length:	681	Identity:	138/681 - (20%)
Similarity:	214/681 - (31%)	Gaps:	201/681 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 WKIVSDFHTLH-------------EFVSAAQSSLQETKVALMEDD-----------PLTQE---- 95
            |:|.|:....|             .:|:.|. ||||..:|..::.           |..||
Frog   100 WRIYSNGEFQHFIDGYNEDKSNWMRYVNPAH-SLQEQNLAACQNGMNIYFYTIKPIPANQELLVW 163

  Fly    96 -TTSFPEIIKLATQEEEGVTEPQELGGRNFFYPEIKIEEHELDTLPRIEILERSANTQENQDQLE 159
             ...|.:.:...|..|..|...|.|..|     |.|.:|           |.:..||.:.:..::
Frog   164 YCRDFADRLHYPTSGELVVNLQQSLTIR-----EEKRKE-----------LTQQKNTPKKEHSVK 212

  Fly   160 GAARRLRKRLKAEDG-----SSVDKDKDEDGVEETAEPAPPKKRRGRPRKSDAAVAP-PQKPKED 218
            ...|.....||.:|.     |::..:|::..|.:...|    :|...||    .|.| |....||
Frog   213 EILRDTTSHLKHKDNLLSSMSAITPEKEKVDVHKNCSP----ERTFFPR----VVYPFPSHIHED 269

  Fly   219 -------IQLDLKAEELDEFVDEETDPDFSCLVPSDNSSEDDG-------GSDGFDSDSDFELDN 269
                   ..:|.:...:...:...|.|.     ||..||.|..       .|.|........|.:
Frog   270 YLKASVGYNMDRQNYLMHSPIQPSTTPS-----PSSRSSPDQSFKSSSPHSSPGSAVSPHHPLQD 329

  Fly   270 GKQEFAVLPKRTVVRP---------KKYKKRTKPAEPKVRMSRELLEQRKKQQEEYDVIIAKFFT 325
            .|:.:..     :.||         ..|...|....|.|              ..|:...:|:.
Frog   330 HKEFYPF-----INRPYNTEGLGSFPTYAPPTSHLPPFV--------------SSYNSTYSKYL- 374

  Fly   326 SVLPCAI-CNLL--------VHNFTEMQR---------------HHRLTHQVDPGYMMCCGRKFT 366
             :.|..| ||.|        ::||....|               ||.|||...||.:...|.:..
Frog   375 -LPPYGIGCNGLNSLNNINAINNFNPFSRMYPVYSSMLAGGSLPHHLLTHAALPGSLPHEGGRRL 438

  Fly   367 QRKVLAEHVLVHWNPDHFKCSVCEKSFQNSR--------------HLESHQQVHMDPAVKLTFSC 417
            .:..|....|:......|..:....|.::.:              .||...|.....||..|.|.
Frog   439 LQPELPRDFLIPAPNSAFSITGAAASMKDKQSSPTSGSPTAGTAASLEHIMQPKPTSAVMSTSSE 503

  Fly   418 DLCSKTFLSKTAIDYHKLNKHVPK--SEFKFTCSECNKKFLTERKLKNHMSSMHDPESTIICDKC 480
            :..:.....:....|..|...:.|  .:.|:.|:.|:|.|.....||.|: .:|..|....|..|
Frog   504 EAINLIKSKRNMTGYKTLPYPLKKQNGKIKYECNVCSKTFGQLSNLKVHL-RVHSGERPFKCQTC 567

  Fly   481 GKQMRTKIILKKHQELMHSDKPRPEPELQQCQICGAWLKGMTGLKQHMKSIHVESAGEHRCHICA 545
            .|.......|:||..:...:||      .:||:|.......:.||.|::.
Frog   568 NKGFTQLAHLQKHFLVHTGEKP------HECQVCHKRFSSTSNLKTHLRL--------------- 611

  Fly   546 KVSPNARALRRHIYHNHECERKFKCTMCEKAFKRPQELKEHTSTHTGEVLYTCPNCPMTF--FCS 608
                            |..|:.::|.:|...|.:...||.|...||.|..:.|.:|..::  .||
Frog   612 ----------------HSGEKPYQCKLCPAKFTQFVHLKLHKRLHTRERPHKCIHCHKSYIHLCS 660

  Fly   609 ANMYK------------HRQRLHRAQYEADK 627
            .|.:.            .|:.|:|...|.:|
Frog   661 LNFHMKGNCPVSPRLGVSREDLNRMNEEIEK 691

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071	8/34 (24%)
		FYDLN_acid	<191..268	CDD:302856	19/91 (21%)
		C2H2 Zn finger	330..351	CDD:275368	10/44 (23%)
		C2H2 Zn finger	360..378	CDD:275368	3/17 (18%)
		LIM	361..>400	CDD:295319	5/52 (10%)
		C2H2 Zn finger	386..406	CDD:275368	4/33 (12%)
		zf-C2H2_8	389..465	CDD:292531	18/91 (20%)
		C2H2 Zn finger	417..438	CDD:275368	2/20 (10%)
		C2H2 Zn finger	448..465	CDD:275368	6/16 (38%)
		C2H2 Zn finger	477..498	CDD:275368	6/20 (30%)
		C2H2 Zn finger	511..532	CDD:275368	6/20 (30%)
		C2H2 Zn finger	541..562	CDD:275368	0/20 (0%)
		C2H2 Zn finger	570..590	CDD:275368	6/19 (32%)
		C2H2 Zn finger	598..619	CDD:275368	6/34 (18%)
prdm1	XP_002937203.1	PR-SET_PRDM1	45..172	CDD:380964	15/72 (21%)
		COG5048	<446..647	CDD:227381	48/238 (20%)
		C2H2 Zn finger	536..556	CDD:275368	7/20 (35%)
		C2H2 Zn finger	564..584	CDD:275368	6/19 (32%)
		zf-H2C2_2	576..601	CDD:372612	8/30 (27%)
		C2H2 Zn finger	592..612	CDD:275368	6/50 (12%)
		C2H2 Zn finger	620..640	CDD:275368	6/19 (32%)
		C2H2 Zn finger	648..666	CDD:275368	5/17 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910