DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and AgaP_AGAP005473

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_001237665.1	Gene:	AgaP_AGAP005473 / 4576351	VectorBaseID:	AGAP005473	Length:	542	Species:	Anopheles gambiae

Alignment Length:	643	Identity:	166/643 - (25%)
Similarity:	252/643 - (39%)	Gaps:	157/643 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDSSP-SCLLCMCEYPAMMGDYIDVHSARGDQLEVTTIVNQHFPVQI-----SKESDERICGRCW 59
            |.:.| :|.||:..            |.||.::.:|   |..|..::     ::......|..|.
Mosquito    29 MKNEPQTCRLCLRS------------SFRGRKIAIT---NGDFQQKLKAIAPAENLPADACRGCR 78

  Fly    60 KIVSDFHTLHEFVSAAQSSLQE--TKVALMEDDPLTQETTSFPEIIKLATQEEEGVTEPQELGGR 122
            :.|..|:...|.|.|.|.|||.  |......|..:.:|:.:     |:|: |....|:|.:
Mosquito    79 ETVEQFYEYSEKVRANQDSLQASITAAGADPDGKVKKESPA-----KVAS-EPNVHTDPAD---- 133

  Fly   123 NFFYPEIKIEEHELDTL---PRIEILERSANTQENQDQLEGAARRLRKRLKAEDGSSVDKDKDED 184
                ..:::|.:.::.|   |.:...::|.:...::..:|..:..|   :|||...|::.|.|..
Mosquito   134 ----SIVQVENYHIELLKVEPCLPATKQSGDVSSDEPVVEYLSESL---VKAESNDSLNYDDDNG 191

  Fly   185 GVEETAEPAPPKKRRGRPRKSDAAVAPPQKPKEDIQLDLKAEELDEFVDEETDPDFSCLVPSDNS 249
            .|.|..||                                       |.||...|
Mosquito   192 DVLEDTEP---------------------------------------VREEPTTD---------- 207

  Fly   250 SEDDGGSDGFDSDSDFELDNGKQEFAVLPKRTVVRPKKYKKRTKPAEPKVRMSRELLEQRKKQQE 314
                             .|.|||...         |::.|:..:|                  :|
Mosquito   208 -----------------EDKGKQNNT---------PQRRKRENRP------------------RE 228

  Fly   315 EYDVIIAKFFTSVLPCAICNLLVHNFTEMQRHHRLTHQVDPGYMMCCGRKFTQRKVLAEHVLVHW 379
            |.:.::.|.|.  |.|..|.........:..|:||.||. |||:.||.|||.:|..|.||:..|.
Mosquito   229 EDEELLRKHFH--LGCEKCPFKAETVAALFHHYRLDHQT-PGYVECCNRKFFRRARLLEHLGAHL 290

  Fly   380 NPDHFKCSVCEKSFQNSRHLESHQQVHMDPAVKLTFSCDLCSKTFLSKTAIDYHK---LNKHVPK 441
            .  ...|.||.|.|:|...|..|:..|..|.....:.|:.|:.:|        ||   |.:|..:
Mosquito   291 G--SIVCDVCGKVFRNVCSLNLHKLDHEQPKHARQYKCERCNYSF--------HKLYHLKQHQKR 345

  Fly   442 SEFKFTCSECNKKFLTERKLKNHMSSMHDPESTIICDKCGKQMRTKIILKKHQELMHSDKPRPEP 506
            .| :..|:.|:|....|:.||.||..:|..::|.||..|||:.|..:.:|:|   :.:.......
Mosquito   346 HE-RLRCTVCDKVLAGEQGLKTHMQKVHGTDNTQICPTCGKEFRCLLAMKRH---IRAHLGIVTV 406

  Fly   507 ELQQCQICGAWLKGMTGLKQHMKSIHVESAGEHRCHICAKVSPNARALRRHIYHNHECERKFKCT 571
            |..||..|..|......|:.|:|.:| :.||..:|..|..||||.|||..|....|..::.|:|.
Mosquito   407 ERVQCDQCAKWFDSKLNLRNHIKGVH-DGAGPIQCDECQHVSPNRRALTNHKLRTHGRKQTFECE 470

  Fly   572 MCEKAFKRPQELKEHTSTHTGEVLYTCPNCPMTFFCSANMYKHRQRLHRAQYEADKNQ 629
            .|.|.......||||.:|||...||:|..|.:||..:||.|.||:..|..::||...|
Mosquito   471 HCGKKLNTKLTLKEHMATHTNIPLYSCEFCGITFNSNANKYVHRKSKHPQEWEAMMQQ 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071	19/78 (24%)
		FYDLN_acid	<191..268	CDD:302856	6/76 (8%)
		C2H2 Zn finger	330..351	CDD:275368	5/20 (25%)
		C2H2 Zn finger	360..378	CDD:275368	9/17 (53%)
		LIM	361..>400	CDD:295319	15/38 (39%)
		C2H2 Zn finger	386..406	CDD:275368	8/19 (42%)
		zf-C2H2_8	389..465	CDD:292531	22/78 (28%)
		C2H2 Zn finger	417..438	CDD:275368	6/23 (26%)
		C2H2 Zn finger	448..465	CDD:275368	6/16 (38%)
		C2H2 Zn finger	477..498	CDD:275368	7/20 (35%)
		C2H2 Zn finger	511..532	CDD:275368	6/20 (30%)
		C2H2 Zn finger	541..562	CDD:275368	10/20 (50%)
		C2H2 Zn finger	570..590	CDD:275368	7/19 (37%)
		C2H2 Zn finger	598..619	CDD:275368	9/20 (45%)
AgaP_AGAP005473	XP_001237665.1	zf-AD	35..100	CDD:285071	19/79 (24%)
		C2H2 Zn finger	272..289	CDD:275368	8/16 (50%)
		C2H2 Zn finger	295..315	CDD:275368	8/19 (42%)
		C2H2 Zn finger	326..346	CDD:275368	7/27 (26%)
		C2H2 Zn finger	380..400	CDD:275368	7/22 (32%)
		C2H2 Zn finger	411..432	CDD:275368	6/20 (30%)
		C2H2 Zn finger	440..461	CDD:275368	10/20 (50%)
		C2H2 Zn finger	469..489	CDD:275368	7/19 (37%)
		C2H2 Zn finger	497..515	CDD:275368	8/17 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000909
OrthoInspector	1	1.000	-	-		mtm14827
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.870