DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and AgaP_AGAP005480

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_001237668.1	Gene:	AgaP_AGAP005480 / 4576343	VectorBaseID:	AGAP005480	Length:	550	Species:	Anopheles gambiae

Alignment Length:	674	Identity:	188/674 - (27%)
Similarity:	282/674 - (41%)	Gaps:	161/674 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDSSPSCLLCM--CE----YPAMMGDYIDVHSARGDQLEVTTIVNQHFPVQISKESDERICGRCW 59
            ||.  .|.||:  |.    .|...|::       |.:|:...    .||:.......||:|..|.
Mosquito    15 MDE--KCRLCLECCNSTNATPITDGEF-------GSKLQKVF----KFPILPEDTLPERVCHECV 66

  Fly    60 KIVSDFHTLHEFVSAAQSSLQETKVALMEDDPLTQETTSFPEIIKLATQEEEGVTEPQELGGRNF 124
            .|||||||..:.:.:.|..||                          ||.:|...:|.|:
Mosquito    67 TIVSDFHTYSQRIQSNQEQLQ--------------------------TQLKEQKFQPFEV----- 100

  Fly   125 FYPEIKIEEHELDTLPRIEILERSANTQENQDQLEGAARRLRKRLKAEDGSSVDKDKDEDGVEET 189
                :|||                  |.|:.|..:......|:||            :||..|:|
Mosquito   101 ----VKIE------------------TLEDDDFYDAEMEEARERL------------EEDATEQT 131

  Fly   190 AEPA---PPKKRRGRPRKSDAAVAPPQKPKEDIQLDLKAE---ELDEFVDEETDPDFSCLVPSDN 248
            ...:   .|.||..:|..::||         |:...|:.|   |.||.:|:|.|.||   ||..:
Mosquito   132 VHVSATRKPAKRAPKPSDTEAA---------DVSDALREEAEGEEDEEIDDEDDEDF---VPKVD 184

  Fly   249 SSEDDGGSDGFDSDSDFELDNGKQEFAVLPKRTVVRPK---------KYKKRTKPAEPKVRMSRE 304
            ..:                  |..:..|..:|.:.:.|         |.:|:.:..||
Mosquito   185 PKD------------------GTLKVPVRRRRRLAQVKAPPKKRTTLKTEKQVEKLEP------- 224

  Fly   305 LLEQRKKQQEEYDVIIAKFFTSVLPCAICNLLVHNFTEMQRHHRLTHQVDPGYMMCCGRKFTQRK 369
              |:..||.|| |..|.:|:.  ..|..|:|.:.:|.::|.|:|..|.. .||:.||.:.|.:|.
Mosquito   225 --EELAKQHEE-DRRIQEFYK--FECEHCSLPMDSFADLQVHYRREHST-KGYVRCCEKVFYRRF 283

  Fly   370 VLAEHVLVHWNPDHFKCSVCEKSFQNSRHLESHQQVHMDPAVKLTFSCDLCSKTFLSKTAIDYHK 434
            .|.:|:..|...  .||.||:||:::||:|..|............|.||.|.::|..:..:..|:
Mosquito   284 QLLDHIAAHQGT--IKCEVCQKSYKSSRYLALHMMKSHSREEDRPFKCDKCRQSFHKEHLLKAHQ 346

  Fly   435 LNKHVPKSEFKFTCSECNKKFLTERKLKNHMSSMHDPESTIICDKCGKQMRTKIILKKH-QELMH 498
            .| |:.:.     |..|.|...::..||.|::.||..:|..|||.|||:.|||..:::| .|.|.
Mosquito   347 AN-HLSEK-----CPICEKVVSSKYALKTHVAHMHGSDSNQICDVCGKEFRTKQAMERHINEHMG 405

  Fly   499 SDKPRPEPELQQCQICGAWLKGMTGLKQHMKSIHVESAGEHRCHICAKVSPNARALRRHIYHNHE 563
            .|    ..:..||.:|..|..|...|::|::.:|:|.....||.:|...|||:|||..|....|.
Mosquito   406 VD----VVQKLQCNVCQRWFHGKYNLRKHVRFMHLEGGQVFRCDLCPHESPNSRALLDHKKRVHV 466

  Fly   564 CERKFKCTMCEKAFKRPQELKEHTSTHTGEVLYTCPNCPMTFFCSANMYKHRQRLHRAQYEADKN 628
            .|| |.|.:|.|.|||...||||.::|||:.||.|..|...|..:||.|.||:..|..:::|.:.
Mosquito   467 VER-FACELCGKRFKRKLYLKEHIASHTGQPLYECGICDAKFNSNANCYNHRKSKHPEEWQARRQ 530

  Fly   629 QPKPPNILKISRNASTQNKPKQEI 652
            .     ..:..|.|......|:|:
Mosquito   531 A-----FFEAQRKAPDSELKKEEV 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071	23/79 (29%)
		FYDLN_acid	<191..268	CDD:302856	19/82 (23%)
		C2H2 Zn finger	330..351	CDD:275368	7/20 (35%)
		C2H2 Zn finger	360..378	CDD:275368	6/17 (35%)
		LIM	361..>400	CDD:295319	14/38 (37%)
		C2H2 Zn finger	386..406	CDD:275368	9/19 (47%)
		zf-C2H2_8	389..465	CDD:292531	20/75 (27%)
		C2H2 Zn finger	417..438	CDD:275368	6/20 (30%)
		C2H2 Zn finger	448..465	CDD:275368	5/16 (31%)
		C2H2 Zn finger	477..498	CDD:275368	10/21 (48%)
		C2H2 Zn finger	511..532	CDD:275368	6/20 (30%)
		C2H2 Zn finger	541..562	CDD:275368	9/20 (45%)
		C2H2 Zn finger	570..590	CDD:275368	10/19 (53%)
		C2H2 Zn finger	598..619	CDD:275368	8/20 (40%)
AgaP_AGAP005480	XP_001237668.1	zf-AD	19..89	CDD:285071	24/106 (23%)
		C2H2 Zn finger	245..265	CDD:275368	7/19 (37%)
		C2H2 Zn finger	273..292	CDD:275368	6/18 (33%)
		C2H2 Zn finger	298..319	CDD:275368	9/20 (45%)
		C2H2 Zn finger	329..349	CDD:275368	6/20 (30%)
		C2H2 Zn finger	354..371	CDD:275368	5/16 (31%)
		C2H2 Zn finger	383..403	CDD:275368	9/19 (47%)
		C2H2 Zn finger	414..462	CDD:275368	18/47 (38%)
		C2H2 Zn finger	444..465	CDD:275368	9/20 (45%)
		C2H2 Zn finger	472..492	CDD:275368	10/19 (53%)
		C2H2 Zn finger	500..518	CDD:275368	7/17 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	74	1.000	Domainoid score	I16069
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000909
OrthoInspector	1	1.000	-	-		mtm14827
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.870