DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and AgaP_AGAP005483

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_001237671.2	Gene:	AgaP_AGAP005483 / 4576335	VectorBaseID:	AGAP005483	Length:	548	Species:	Anopheles gambiae

Alignment Length:	690	Identity:	175/690 - (25%)
Similarity:	282/690 - (40%)	Gaps:	187/690 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDSSPSCLLCMCEYPAMMGDYIDVHSARGDQLEVTTIVNQH-----------FPVQISKESDERI 54
            ||.  .|.||:               ||.:.|.....:.:.           ||:...:.....:
Mosquito     1 MDE--KCRLCL---------------ARLENLRSNATIEEEGFREKLKTLFSFPITSIEAFPSTV 48

  Fly    55 CGRCWKIVSDFHTLHEFVSAAQSSLQETKVALMEDDPLTQETTSFPEIIKLATQEEEGVTEPQEL 119
            |.:|...||||||.||.|.:.|..|                         .:||.::
Mosquito    49 CVQCEARVSDFHTYHEQVKSNQDQL-------------------------WSTQHQK-------- 80

  Fly   120 GGRNFFYPEIKIE-----EHELDTLPRIEILERSANTQENQDQLEGAARRLRKRLKAEDGSSVDK 179
                 ::.|:|:|     ::::..||.:|: |.....|:...:.|..::..:::|:..|..::|.
Mosquito    81 -----YFEEVKVEPAPDADYDVFELPFVEV-EPVEGAQKESCKNEPDSKCQQQQLQQLDEQTIDS 139

  Fly   180 DKDEDGVEETAEPAPPKKRRGRPRKSDAAVAPPQKPKEDIQLDLKAEELDEFVDEETDPDFSCLV 244
            |.| ||::...|..||        .|.||
Mosquito   140 DLD-DGMKLEDEYNPP--------SSSAA------------------------------------ 159

  Fly   245 PSDNSSEDDGGSDGFDSDSDFELDNGKQEFAVLPKRTV--------------VRPKKYKKRTK-P 294
             |:|:|:|                   .|:.|.|:|:.              .||.|.:..|: |
Mosquito   160 -SNNNSDD-------------------SEYEVKPRRSKRVTDTADRTRTTRRGRPPKSEAGTRSP 204

  Fly   295 AEPK------VRMSRELLEQRKKQQEEYDVIIAKFFTSVLPCAICNLLVHNFTEMQRHHRLTHQV 353
            .:.|      ||..:...|..:|.:|.||          :.|.:|...:.:||.::.|:..||:.
Mosquito   205 GQQKKKSPIVVRRCQATNETNQKLREFYD----------MKCEMCEEQLESFTALKNHYYRTHRT 259

  Fly   354 DPGYMMCCGRKFTQRKVLAEHVLVHWNPDHFKCSVCEKSFQNSRHLESHQ-QVHMDPAVKLTFSC 417
             |||:.||||.|..|..|.||:..|......:|..|.|:|.:..:|..|: :|| ..|....:.|
Mosquito   260 -PGYIKCCGRTFHSRYRLLEHLSYHVGSSMVRCEECNKTFSSRSYLLVHRSRVH-GQAEDRPYKC 322

  Fly   418 DLCSKTFLSKTAIDYHKLNKHVPKSEFKFTCSECNKKFLTERKLKNHMSSMHDPESTIICDKCGK 482
            ..|.:::    |::.| |..|: .|..:..|:.|.|:..:...|:.||.:||......|||.||:
Mosquito   323 TQCHQSY----AMECH-LKAHI-VSHVRVNCTICGKELASALSLRTHMINMHGNRENHICDSCGR 381

  Fly   483 QMRTKIILKKHQELMHSDKPRPEPELQQCQICGAWLKGMTGLKQHMKSIHVESAGEHRCHICAKV 547
            :.|::...::|.:| |..  ....|..||::|..||.....||.|:|.:|:|:....:|.||::.
Mosquito   382 EFRSRQAFERHVKL-HLG--LEVAEQVQCEVCHKWLNSKRALKMHVKLVHMEAGQTFQCDICSQQ 443

  Fly   548 SPNARALRRHIYHNHECERKFKCTMCEKAFKRPQELKEHTST-HTGEVLYTCPNCPMTFFCSANM 611
            .||:|||..|....| .|.:|||..|.|.|||...||||.:. ||.:.||:|..|..||..:||.
Mosquito   444 CPNSRALANHKQRVH-VEERFKCEECGKLFKRQLYLKEHVAALHTRKPLYSCEVCGATFNSNANK 507

  Fly   612 YKHRQRLHRAQYEADKNQPKPPNILKISRNASTQNKPKQE 651
            |.||:..|..::|..:.|.     |:..:....|::.:|:
Mosquito   508 YSHRKNKHPVEWEERRKQQ-----LQQQQEQQQQHQQQQQ 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071	21/84 (25%)
		FYDLN_acid	<191..268	CDD:302856	10/76 (13%)
		C2H2 Zn finger	330..351	CDD:275368	5/20 (25%)
		C2H2 Zn finger	360..378	CDD:275368	9/17 (53%)
		LIM	361..>400	CDD:295319	13/38 (34%)
		C2H2 Zn finger	386..406	CDD:275368	6/20 (30%)
		zf-C2H2_8	389..465	CDD:292531	19/76 (25%)
		C2H2 Zn finger	417..438	CDD:275368	5/20 (25%)
		C2H2 Zn finger	448..465	CDD:275368	4/16 (25%)
		C2H2 Zn finger	477..498	CDD:275368	7/20 (35%)
		C2H2 Zn finger	511..532	CDD:275368	8/20 (40%)
		C2H2 Zn finger	541..562	CDD:275368	9/20 (45%)
		C2H2 Zn finger	570..590	CDD:275368	10/20 (50%)
		C2H2 Zn finger	598..619	CDD:275368	9/20 (45%)
AgaP_AGAP005483	XP_001237671.2	zf-AD	5..73	CDD:214871	20/82 (24%)
		C2H2 Zn finger	236..257	CDD:275368	5/20 (25%)
		C2H2 Zn finger	265..283	CDD:275368	9/17 (53%)
		C2H2 Zn finger	291..312	CDD:275368	6/20 (30%)
		C2H2 Zn finger	322..363	CDD:275368	11/46 (24%)
		C2H2 Zn finger	347..367	CDD:275368	6/19 (32%)
		C2H2 Zn finger	376..396	CDD:275368	7/20 (35%)
		C2H2 Zn finger	407..426	CDD:275368	7/18 (39%)
		C2H2 Zn finger	437..458	CDD:275368	9/20 (45%)
		C2H2 Zn finger	465..486	CDD:275368	10/20 (50%)
		C2H2 Zn finger	494..512	CDD:275368	8/17 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000909
OrthoInspector	1	1.000	-	-		mtm14827
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.870