DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and AgaP_AGAP005482

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_001237670.2	Gene:	AgaP_AGAP005482 / 4576334	VectorBaseID:	AGAP005482	Length:	368	Species:	Anopheles gambiae

Alignment Length:	393	Identity:	105/393 - (26%)
Similarity:	152/393 - (38%)	Gaps:	105/393 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   298 KVRMSRELLEQRKK---QQEEYDVIIAKFFT-------SVL---PCAICNLLVHNFTEMQRHHRL 349
            |.|:..:.:..||.   ..:|:..::::.||       |||   .||.|.|:|.||      :..
Mosquito     4 KCRLCLKKIGARKGASITDDEFGAMLSRVFTFPVAVTESVLLVNVCAKCALMVRNF------NAF 62

  Fly   350 THQVDPGYMMCCGRKFTQRKVLAEHVLVHWNPDHFKCSVCEKSFQNSRHLES--HQQVHMDPAVK 412
            :.:|:           ..:.||...::|.               |..|.|:.  |..|..:...:
Mosquito    63 SEEVE-----------ANQNVLLSELMVE---------------QKGRKLDDVPHGTVEKEEHTQ 101

  Fly   413 LTFSCDLCSKTFLSKTAIDY---HKLNKHVPKSEFKFTCSECNKKFLTER--------------- 459
            :..|.:|..|. ..:...|.   |.|.|.|...|     ||.|||...|.
Mosquito   102 VISSRELTVKP-KGREVEDVKHDHSLTKPVLDQE-----SETNKKKPVENLADDDDGTASMLPIE 160

  Fly   460 ----KLKNHMS---SMHDPESTIICDKCGKQMRTK---------II---------LKKHQELMHS 499
                .||..:.   |..|..||...|......|:|         ||         :|:||.:...
Mosquito   161 DMEVLLKEQLDDDFSTDDNNSTTHTDDKAPNSRSKKPDLHENDRIIMEFLALDRHIKQHQGIETI 225

  Fly   500 DKPRPEPELQQCQICGAWLKGMTGLKQHMKSIHVESAGEHRCHICAKVSPNARALRRHIYHNHEC 564
            :|       ..|..||..|.|...|::|::.:|||:...:||.:|...|||:.||..|....|..
Mosquito   226 EK-------LDCPHCGKQLNGKYNLQKHVRCMHVEAGKSYRCEVCGHFSPNSVALENHKKRVHTG 283

  Fly   565 ERKFKCTMCEKAFKRPQELKEHTST-HTGEVLYTCPNCPMTFFCSANMYKHRQRLHRAQYEADKN 628
            |. |:|..|.|.||:...|.||.:. ||.:.||.|..|..||...||.|.||:..|||::||.:.
Mosquito   284 EH-FECGECGKRFKQKIYLTEHVAALHTRKPLYACEFCEATFKSRANYYTHRKTRHRAEWEALRE 347

  Fly   629 QPK 631
            :.|
Mosquito   348 ERK 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856
		C2H2 Zn finger	330..351	CDD:275368	7/20 (35%)
		C2H2 Zn finger	360..378	CDD:275368	2/17 (12%)
		LIM	361..>400	CDD:295319	5/38 (13%)
		C2H2 Zn finger	386..406	CDD:275368	4/21 (19%)
		zf-C2H2_8	389..465	CDD:292531	22/99 (22%)
		C2H2 Zn finger	417..438	CDD:275368	5/23 (22%)
		C2H2 Zn finger	448..465	CDD:275368	8/35 (23%)
		C2H2 Zn finger	477..498	CDD:275368	8/38 (21%)
		C2H2 Zn finger	511..532	CDD:275368	7/20 (35%)
		C2H2 Zn finger	541..562	CDD:275368	8/20 (40%)
		C2H2 Zn finger	570..590	CDD:275368	8/20 (40%)
		C2H2 Zn finger	598..619	CDD:275368	9/20 (45%)
AgaP_AGAP005482	XP_001237670.2	zf-AD	5..75	CDD:214871	19/86 (22%)
		C2H2 Zn finger	230..250	CDD:275368	7/19 (37%)
		C2H2 Zn finger	260..281	CDD:275368	8/20 (40%)
		C2H2 Zn finger	288..309	CDD:275368	8/20 (40%)
		C2H2 Zn finger	317..336	CDD:275368	9/18 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000909
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.870