DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and AgaP_AGAP005481

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_001237669.1	Gene:	AgaP_AGAP005481 / 4576333	VectorBaseID:	AGAP005481	Length:	490	Species:	Anopheles gambiae

Alignment Length:	528	Identity:	165/528 - (31%)
Similarity:	237/528 - (44%)	Gaps:	100/528 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 RNFFYPEIKIEEHELDTLPRIEILERSANTQEN----QDQLEGAARRLRKRLKAEDGSSVDKDKD 182
            ||.|..||..||    .||. ::.::...|...    ..|:|...|:||..|      :.|.|
Mosquito    30 RNVFLFEISTEE----PLPE-QVCQQCQTTVAEFHVYSQQVEANQRQLRLEL------ATDTD-- 81

  Fly   183 EDGVEETAEPAPPKKRRGRPRKSDAAVAPPQKPKEDIQLD-LKAEELDEFVDEETDPDFSCLVPS 246
                   .||.|.|            |.|      |:|:: :.||.|     ||..|...|:
Mosquito    82 -------VEPEPVK------------VEP------DLQIEIMPAEGL-----EELPPGIECV--- 113

  Fly   247 DNSSEDDGGSDGFDSDSDFELDNGKQEFAVLPKRTVVRPKKYKKRTKPAEPKVRMSR--ELLEQR 309
             :..|:..||....|:||.|. |...|:.|..:|        |.|.|..|.|.|..|  |..|:.
Mosquito   114 -DVKEEYDGSITAQSESDLEA-NTDDEYVVATRR--------KVRRKARERKERKERKEESAERG 168

  Fly   310 K--------KQQEEYDVIIAKFFTSVLPCAICNLLVHNFTEMQRHHRLTHQVDPGYMMCCGRKFT 366
            |        .:|:|.|..|.:|:|  |.|.||::|:.:|.::|.|::|.|.. .||:.||.::..
Mosquito   169 KDKSEGNGAARQQEKDDRIKEFYT--LECEICSILLDDFVQLQEHYQLVHDT-RGYIRCCNKQLF 230

  Fly   367 QRKVLAEHVLVHWNPDHFKCSVCEKSFQNSRHLESHQQVHMDPAVKLTFSCDLCSKTFLSKTAID 431
            .|..|.:|:.||...  .:|.||:::::..|:|..|.........:..|.||.|...:..:..:.
Mosquito   231 HRYTLLDHIAVHRGT--IRCEVCDRTYKTKRYLALHMAKSHGTEEERPFKCDQCGLAYPKQYLLR 293

  Fly   432 YHKLNKHVPKSEFKFTCSECNKKFLTERKLKNHMSSMHDPESTIICDKCGKQMRTKIILKKH-QE 495
            .|:| .||     :..|..|.|...:...||.|::.||..:...||..|||..|||..:::| :|
Mosquito   294 SHQL-MHV-----QAECHVCKKVLSSNYALKVHLTQMHSDDGNQICATCGKIFRTKAAMERHIKE 352

  Fly   496 LMHSDKPRPEP-ELQQCQICGAWLKGMTGLKQHMKSIHVESAGEHRCHICAKVSPNARAL----- 554
            .|..     || |..||:.|..|..|...|.:|::.:|.|.....||.:||..|||:|||
Mosquito   353 HMGL-----EPIERMQCEYCQKWFNGKYNLNKHIRFLHNERGQVFRCDLCAHESPNSRALSYHKQ 412

  Fly   555 RRHIYHNHECERKFKCTMCEKAFKRPQELKEHTSTHTGEVLYTCPNCPMTFFCSANMYKHRQRLH 619
            |.|:...||||      :|.|.|||...|:||.::||...||||..|.|.|...||.:.||:..|
Mosquito   413 RVHVQEKHECE------LCGKRFKRKLYLREHIASHTNVPLYTCEYCGMKFNSHANHFTHRKNKH 471

  Fly   620 RAQYEADK 627
            ..::||.|
Mosquito   472 PEEWEAHK 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856	22/77 (29%)
		C2H2 Zn finger	330..351	CDD:275368	8/20 (40%)
		C2H2 Zn finger	360..378	CDD:275368	5/17 (29%)
		LIM	361..>400	CDD:295319	10/38 (26%)
		C2H2 Zn finger	386..406	CDD:275368	6/19 (32%)
		zf-C2H2_8	389..465	CDD:292531	17/75 (23%)
		C2H2 Zn finger	417..438	CDD:275368	5/20 (25%)
		C2H2 Zn finger	448..465	CDD:275368	5/16 (31%)
		C2H2 Zn finger	477..498	CDD:275368	9/21 (43%)
		C2H2 Zn finger	511..532	CDD:275368	6/20 (30%)
		C2H2 Zn finger	541..562	CDD:275368	11/25 (44%)
		C2H2 Zn finger	570..590	CDD:275368	8/19 (42%)
		C2H2 Zn finger	598..619	CDD:275368	8/20 (40%)
AgaP_AGAP005481	XP_001237669.1	zf-AD	5..73	CDD:214871	13/47 (28%)
		C2H2 Zn finger	225..242	CDD:275368	4/16 (25%)
		C2H2 Zn finger	248..269	CDD:275368	6/20 (30%)
		C2H2 Zn finger	279..299	CDD:275368	5/20 (25%)
		C2H2 Zn finger	304..321	CDD:275368	5/16 (31%)
		C2H2 Zn finger	333..353	CDD:275368	8/19 (42%)
		C2H2 Zn finger	364..380	CDD:275368	5/15 (33%)
		C2H2 Zn finger	394..415	CDD:275368	10/20 (50%)
		C2H2 Zn finger	422..442	CDD:275368	10/25 (40%)
		C2H2 Zn finger	450..468	CDD:275368	7/17 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	74	1.000	Domainoid score	I16069
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000909
OrthoInspector	1	1.000	-	-		mtm14827
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.870