DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and br

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_001162638.2	Gene:	br / 44505	FlyBaseID:	FBgn0283451	Length:	1011	Species:	Drosophila melanogaster

Alignment Length:	859	Identity:	150/859 - (17%)
Similarity:	253/859 - (29%)	Gaps:	328/859 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDSSPSCLLCMCEYPAMM---GDYIDVHSARGDQLEVTTIVNQHFPVQISKESDE---------R 53
            :.|:|      |::|.::   .:::|:|:.      |..|  .|..|.:.::|.:         |
  Fly    61 LKSTP------CKHPVILLQDVNFMDLHAL------VEFI--YHGEVNVHQKSLQSFLKTAEVLR 111

  Fly    54 ICGRCWKIVSDFHT-LHEFVSAAQSSLQETKVALMEDDPLTQETTSFPE-----------IIKLA 106
            :.|...:...|.|: |.:..:.|.|..:         .||...|.|.|.           ...|.
  Fly   112 VSGLTQQQAEDTHSHLAQIQNLANSGGR---------TPLNTHTQSLPHPHHGSLHDDGGSSTLF 167

  Fly   107 TQEEEGVTEPQELGGRNFFYPEIKIEEHELDTLPRIEILERS---ANTQENQDQLEGAARRLRKR 168
            :::..|...|..:       |.:....:. ..|.|:.::.||   |..:|.....        ||
  Fly   168 SRQGAGSPPPTAV-------PSLPSHINN-QLLKRMAMMHRSSAAAAAEETSHAF--------KR 216

  Fly   169 LKAEDGSSVDKDKDEDGVEETAEPAPP-KKRRGRPRKSDAAVA----------PPQKPKE----- 217
            |:..|.|.........|....:...|| ..|...|:::.|..:          ||.|.::
  Fly   217 LRGSDNSLPLSGAVGSGSNNNSPDLPPLHARSASPQQTPADFSTIKHHNNNNTPPLKEEKRNGPT 281

  Fly   218 -------------------DIQL------------------DLKAEELDEF-------VDEETDP 238
                               .|.:                  |:|:|.:|..       .::|...
  Fly   282 GNGNSGNGNGNGNGASNGNGISISDKLGSLTPSPLARAGADDVKSEPMDMVCSNNNANANDEHSN 346

  Fly   239 DFSCLVPSDNSSEDDGGSDGFDSDSDFELDNGKQEFAVLPKRTVVRPKKYKKRTKPAEPKVRMSR 303
            |.:....::.||..|||.....|.:|.|:.:|.......|:..:          .|||.|:..:
  Fly   347 DSTGEHDANRSSSGDGGKGSLSSGNDEEIGDGLASHHAAPQFIM----------SPAENKMFHA- 400

  Fly   304 ELLEQRKKQQEEYDVIIAKF-FTSVLPCAICNLLVHNFTEMQRHHRLTHQVDP----------GY 357
                             |.| |.::.|.|:..|    .|::|:...|.  |.|          |.
  Fly   401 -----------------AAFNFPNIDPSALLGL----NTQLQQSGDLA--VSPQGGSTGSLLSGV 442

  Fly   358 MMCCGRKFT----------------QRKV---LAEHVLV---HWNPDHFKCSVCEKSFQNSRHLE 400
            ::..|...|                |:||   .:.|.|:   |.:..|          .||..|:
  Fly   443 IVPGGSGGTPSNSSSNNNNNNSNNQQQKVEQQSSPHQLLQQQHHSTPH----------TNSPQLK 497

  Fly   401 SHQQVHMDPAVKLTFSCDL----CSKTFLSKTA----------------IDYHKLNKHVPKSEFK 445
            ..|......:.|   |.||    .|:..||:::                ..|||..:...:...:
  Fly   498 QEQPKSGGGSCK---SSDLHIAAGSERSLSRSSQGMPDAGGHSATPSPTAAYHKRERERERERER 559

  Fly   446 FTCSECNKKFLTERKLK-------------NHMS-----------SMHDPEST------------ 474
            ....|..:....||.|:             :|.|           |.|...:|
  Fly   560 ERERERERSLDHERDLERPGGTGSPPPPPPSHHSHFGQHPLSLLPSHHQLHATHHELSAAAAHHA 624

  Fly   475 ---------IICDKCGKQMRTKIILKKHQELMHSDKPRPEPELQQCQICGAWLKG---------M 521
                     ....:.|..|       :|..|:|..:....|........||..:|         .
  Fly   625 HAHAHAAHAHALARAGSPM-------EHHHLLHHRRASLSPSGAVSSASGAGGRGGGAGGPGGPG 682

  Fly   522 TGLKQHMKSIHVESAGE----------HRCHICAKVSPNARALRRHIYHNH-ECERKFKCTMCEK 575
            ..|...:::..|..|..          |||.:|.|:......|:||....| :......|.:|.|
  Fly   683 GSLLSSVRAQDVAQANRLLLPLPLNACHRCDVCGKLLSTKLTLKRHKEQQHLQPLNNAVCNLCHK 747

  Fly   576 AFKRPQELKEHTSTHTGEVLYTCPNCPMTFFCSANMYKHRQRLHRAQYE--ADKNQPKPP----- 633
            .|:....|..|.|                      :|..||:.|.:.:.  |..:|...|
  Fly   748 VFRTLNSLNNHKS----------------------IYHRRQKNHHSYFHHGAGVSQAGSPGSRLH 790

  Fly   634 -NILKISRNASTQN 646
             ::..:|..|:..|
  Fly   791 QSLSSLSAAAAAAN 804

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071	16/86 (19%)
		FYDLN_acid	<191..268	CDD:302856	23/136 (17%)
		C2H2 Zn finger	330..351	CDD:275368	5/20 (25%)
		C2H2 Zn finger	360..378	CDD:275368	7/39 (18%)
		LIM	361..>400	CDD:295319	11/60 (18%)
		C2H2 Zn finger	386..406	CDD:275368	4/19 (21%)
		zf-C2H2_8	389..465	CDD:292531	18/108 (17%)
		C2H2 Zn finger	417..438	CDD:275368	8/40 (20%)
		C2H2 Zn finger	448..465	CDD:275368	4/29 (14%)
		C2H2 Zn finger	477..498	CDD:275368	4/20 (20%)
		C2H2 Zn finger	511..532	CDD:275368	4/29 (14%)
		C2H2 Zn finger	541..562	CDD:275368	6/20 (30%)
		C2H2 Zn finger	570..590	CDD:275368	7/19 (37%)
		C2H2 Zn finger	598..619	CDD:275368	3/20 (15%)
br	NP_001162638.2	BTB	22..118	CDD:279045	13/70 (19%)
		BTB	33..118	CDD:197585	13/70 (19%)
		C2H2 Zn finger	712..729	CDD:275368	5/16 (31%)
		C2H2 Zn finger	742..763	CDD:275368	7/42 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910