DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and Zfp738

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_001001187.2	Gene:	Zfp738 / 408068	MGIID:	3040706	Length:	793	Species:	Mus musculus

Alignment Length:	636	Identity:	154/636 - (24%)
Similarity:	246/636 - (38%)	Gaps:	162/636 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 QETTSFPEIIKLATQEEEGVTEPQELGGRNFFYPEIKIEEHE-------LDTLP-RIEILERSAN 150
            ||..||.::....:.||....||.:|.    .|.::.:|.:.       ..:.| .:..||:
Mouse    12 QEMLSFRDVAIDFSAEEWECLEPAQLD----LYRDVMLENYSNLVFLGLASSKPYLVTCLEQ--- 69

  Fly   151 TQENQDQLEGAARRL---RKRLKAEDGSSVDKDKDEDGVEETAEPAPPKKRRGRPRKSDAAVAPP 212
            .||..|...|||..:   ||..|.::...|.        |.|
Mouse    70 IQEPSDVKRGAATSMLPERKCYKCKECGKVS--------EWT----------------------- 103

  Fly   213 QKPKEDIQ-LDLKAEELDEFVDEETDPDFSCLVPSDNSSEDDGGSDGFDSDSDFELDNGKQEFAV 276
             |..::.| |||   .::.:..||....|..  || .|||::....|   :..::.:...:.|.:
Mouse   104 -KVFQNHQMLDL---GMNYYKCEECAKSFHS--PS-LSSEENRIHAG---EKPYKCEVCGKAFCI 158

  Fly   277 ---LPKRTVVRPKK--YKKRT--KPAEPKVRMSRELLEQRKKQQEE--YDVII---AKFFTSVL- 328
               |.|..::...:  ||...  |..:...|:||    .:|...||  |...:   |..|.|:|
Mouse   159 PLLLSKHKIIHKGENLYKCEVCGKAFQHPSRLSR----HKKIHSEEKPYKCEVCGKAFHFPSLLL 219

  Fly   329 ------------PCAICNLLVHNFTEMQRHHRLTHQVDPGYMMC--CGRKFTQRKVLAEHVLVHW 379
                        .|.:|....|..:...:|.|: |..:..| .|  ||:.|.....|::|.::|.
Mouse   220 VHKRVHTGEKPYKCTVCGKAFHYPSIFSKHKRI-HTGEKPY-KCEECGKAFHISSFLSKHKIIHR 282

  Fly   380 NPDHFKCSVCEKSFQNSRHLESHQQVHMDPAVKLTFSCDLCSKTFLSKTAIDYHKLNKHVPKSEF 444
            ....:||.||.|:|.....|.:|:::|   :.:..|.|::|.|.|...:.:..||: .|..::.:
Mouse   283 GEKPYKCEVCGKAFHYPSRLSNHKKIH---SGEKPFKCEVCGKAFRILSLLSKHKI-IHTEENPY 343

  Fly   445 KFTCSECNKKFLTERKLKNHMSSMHDPESTIICDKCGKQMRT-------KII------------- 489
            |  |..|.|.|....:|.|| :.||..|....|:.|.|..|:       |.|
Mouse   344 K--CEVCGKAFDYPSRLSNH-AEMHTREKPYKCEVCQKAFRSLSSFSKHKRIHTKDNYYNSELCG 405

  Fly   490 --------LKKHQELMHSDKPRPEPELQQCQICGAWLKGMTGLKQHMKSIHVESAGE--HRCHIC 544
                    |.||:::...:||      .:|::||......:.|.:| ::||   .||  ::|.:|
Mouse   406 KAFIYPSRLSKHKKICAGEKP------YKCEVCGKAFHVASLLSKH-RTIH---TGEKLYKCEVC 460

  Fly   545 AKVSPNARALRRHIYHNHECERKFKCTMCEKAFKRPQELKEHTSTHTGEVLYTCPNCPMTFFCSA 609
            .|.......|..| ...|..|:.|:|.:|.|||..|..|.:|...||||..|.|..|...|...:
Mouse   461 GKAFYYPSRLSNH-KKIHTGEKPFQCEVCGKAFCFPSSLSKHKRIHTGEKPYKCKECGKAFRSLS 524

  Fly   610 NMYKHRQRLHRAQYEADKNQPKP------------PNILKISRNASTQNKP 648
            ::.||: |:|..:        ||            |::|...:...|..||
Mouse   525 SLSKHK-RIHTGE--------KPYKCEECGKAFHYPSLLSKHKIIHTGEKP 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856	14/77 (18%)
		C2H2 Zn finger	330..351	CDD:275368	5/20 (25%)
		C2H2 Zn finger	360..378	CDD:275368	6/19 (32%)
		LIM	361..>400	CDD:295319	12/38 (32%)
		C2H2 Zn finger	386..406	CDD:275368	7/19 (37%)
		zf-C2H2_8	389..465	CDD:292531	21/75 (28%)
		C2H2 Zn finger	417..438	CDD:275368	6/20 (30%)
		C2H2 Zn finger	448..465	CDD:275368	6/16 (38%)
		C2H2 Zn finger	477..498	CDD:275368	9/48 (19%)
		C2H2 Zn finger	511..532	CDD:275368	5/20 (25%)
		C2H2 Zn finger	541..562	CDD:275368	5/20 (25%)
		C2H2 Zn finger	570..590	CDD:275368	8/19 (42%)
		C2H2 Zn finger	598..619	CDD:275368	6/20 (30%)
Zfp738	NP_001001187.2	KRAB	15..73	CDD:214630	13/64 (20%)
		KRAB	15..54	CDD:279668	9/42 (21%)
		C2H2 Zn finger	93..113	CDD:275368	5/51 (10%)
		C2H2 Zn finger	121..141	CDD:275368	8/22 (36%)
		C2H2 Zn finger	149..169	CDD:275368	3/19 (16%)
		C2H2 Zn finger	177..197	CDD:275368	5/23 (22%)
		zf-H2C2_2	190..213	CDD:290200	7/26 (27%)
		C2H2 Zn finger	205..225	CDD:275368	4/19 (21%)
		zf-H2C2_2	218..242	CDD:290200	3/23 (13%)
		C2H2 Zn finger	233..253	CDD:275368	5/20 (25%)
		zf-H2C2_2	246..269	CDD:290200	7/24 (29%)
		COG5048	257..642	CDD:227381	91/338 (27%)
		C2H2 Zn finger	261..281	CDD:275368	6/19 (32%)
		zf-H2C2_2	274..298	CDD:290200	9/23 (39%)
		C2H2 Zn finger	289..309	CDD:275368	7/19 (37%)
		zf-H2C2_2	302..324	CDD:290200	7/24 (29%)
		C2H2 Zn finger	317..337	CDD:275368	6/20 (30%)
		C2H2 Zn finger	345..365	CDD:275368	7/20 (35%)
		C2H2 Zn finger	373..393	CDD:275368	5/19 (26%)
		C2H2 Zn finger	404..421	CDD:275368	3/16 (19%)
		C2H2 Zn finger	429..449	CDD:275368	5/20 (25%)
		C2H2 Zn finger	457..477	CDD:275368	5/20 (25%)
		zf-H2C2_2	470..492	CDD:290200	8/22 (36%)
		C2H2 Zn finger	485..505	CDD:275368	8/19 (42%)
		zf-H2C2_2	497..522	CDD:290200	10/24 (42%)
		C2H2 Zn finger	513..533	CDD:275368	6/20 (30%)
		zf-H2C2_2	525..550	CDD:290200	6/33 (18%)
		C2H2 Zn finger	541..561	CDD:275368	2/19 (11%)
		C2H2 Zn finger	569..589	CDD:275368
		C2H2 Zn finger	597..617	CDD:275368
		C2H2 Zn finger	625..645	CDD:275368
		C2H2 Zn finger	653..673	CDD:275368
		C2H2 Zn finger	681..701	CDD:275368
		C2H2 Zn finger	710..729	CDD:275368
		C2H2 Zn finger	737..757	CDD:275368
		C2H2 Zn finger	765..784	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910