DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and znf131

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_956799.2	Gene:	znf131 / 393477	ZFINID:	ZDB-GENE-040426-1563	Length:	558	Species:	Danio rerio

Alignment Length:	629	Identity:	124/629 - (19%)
Similarity:	197/629 - (31%)	Gaps:	212/629 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 HFPVQISKESDERICGRCWKI--VSDFHTL--HEFVSAAQSSLQETKVALMEDDPLTQETTSFPE 101
            |:.|.:.|.:::|...:...|  :.|.|..  |:.|.||.|............:||.
Zfish    16 HYKVMLDKLNEQRQLDQFTDITLIVDGHQFRAHKAVLAACSQFFHKFFQDFTQEPLV-------- 72

  Fly   102 IIKLATQEEEGVTEPQELGGRNFFYP---EIKIEEHELDTLPRIEILERSANTQENQDQLEGAAR 163
                   |.|||:.........|.|.   .:..||...|.....|.|           |::.|.:
Zfish    73 -------EIEGVSNSAFRHLMEFTYTATLAVNGEEEVSDVWRAAEYL-----------QMQEAIK 119

  Fly   164 RLRKRLKAEDGSSVDKDKDEDGVEETAEPAPPKKRRGRPRKSDAA-VAPPQKPKEDIQ-LDLKAE 226
            .|..|...                 |..|.|.|.:..:.:.|:.: |.....|..|.: ::::.|
Zfish   120 ALNNRRNG-----------------TTSPQPGKSKAKKRKISETSNVITESLPSADTEAVEIEVE 167

  Fly   227 ELDEFVD-------EETDPDFSCLVPSDNSSEDDGGSDGFDSDSDFELDNGKQEFAVLPK--RTV 282
            ..:|.::       |..|......||   ||:|...:...|..|.::  .|:|...|:.|  .||
Zfish   168 VGEEHIEVEESGLVEVVDVARGTTVP---SSDDSALALLADITSKYQ--QGEQTLHVIKKVDETV 227

  Fly   283 VRPKKYKKRTKPAEPKVRMSRELLEQRKKQQEEYDVIIAKFFTSVLPCAICNLLVHNFTEMQRHH 347
            |                            .||| .|:.:|...::           ...|:|
Zfish   228 V----------------------------VQEE-AVVASKTLENI-----------EVVEVQ--- 249

  Fly   348 RLTHQVDPGYMMCCGRKFTQRKVLAEHVLVHWNPDHFKCSVCEKSFQNSRHLESHQQVHMDPAVK 412
              ..|:|                           :.|:|..|::.|:...||:.|
Zfish   250 --ISQLD---------------------------NLFRCDKCDRCFKLYYHLKQH---------- 275

  Fly   413 LTFSCDLCSKTFLSKTAIDYHKLNKHVPKSEFKFTCSECNKKFLTERKLKNHMSSMH-DPE---- 472
                                  :..|:...|..|.|..|.|.:..|..||.|:::.| |.|
Zfish   276 ----------------------MKTHIASPERGFVCRHCGKAYAREGALKQHLNNYHFDAEEQSR 318

  Fly   473 ----STIICDKCGKQMRTKIILKKHQELMHSDKPRPEPELQQCQICGAWLKGMTGLKQHMKSIHV 533
                ...:|:.|.||.......|:|......:||      .:|..|.......:.||.||.:
Zfish   319 RQKKKVHVCEYCEKQFDHFGHFKEHLRKHTGEKP------FECPECHERFARNSTLKCHMSA--- 374

  Fly   534 ESAGEHRCHICAKVSPNARALRRHIYHNHECERKFKCTMCEKAFKRPQELKEHTSTHTGEVLYTC 598
                      |...| .|:..|:.:|         :|.:|...|...::.|:|..|||||....|
Zfish   375 ----------CQNGS-GAKKGRKKLY---------ECQVCSSVFNSWEQFKDHLVTHTGEKPNHC 419

  Fly   599 PNCPMTFFCSANMYKHRQRLHRAQYEA----DKNQPKPPNILKI 638
            ..|.:.|....:::.|.|..|..|.:.    |.....|.|:|.:
Zfish   420 TLCDLWFTSPRDLHTHLQEHHSLQEKVIVAEDILISDPANVLSM 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071	12/43 (28%)
		FYDLN_acid	<191..268	CDD:302856	18/85 (21%)
		C2H2 Zn finger	330..351	CDD:275368	2/20 (10%)
		C2H2 Zn finger	360..378	CDD:275368	0/17 (0%)
		LIM	361..>400	CDD:295319	5/38 (13%)
		C2H2 Zn finger	386..406	CDD:275368	6/19 (32%)
		zf-C2H2_8	389..465	CDD:292531	14/75 (19%)
		C2H2 Zn finger	417..438	CDD:275368	0/20 (0%)
		C2H2 Zn finger	448..465	CDD:275368	6/16 (38%)
		C2H2 Zn finger	477..498	CDD:275368	6/20 (30%)
		C2H2 Zn finger	511..532	CDD:275368	6/20 (30%)
		C2H2 Zn finger	541..562	CDD:275368	5/20 (25%)
		C2H2 Zn finger	570..590	CDD:275368	5/19 (26%)
		C2H2 Zn finger	598..619	CDD:275368	5/20 (25%)
znf131	NP_956799.2	BTB	24..120	CDD:306997	24/121 (20%)
		zf-C2H2	257..279	CDD:306579	7/53 (13%)
		C2H2 Zn finger	259..279	CDD:275368	6/51 (12%)
		C2H2 Zn finger	289..347	CDD:275368	16/57 (28%)
		COG5048	<310..441	CDD:227381	37/159 (23%)
		C2H2 Zn finger	327..344	CDD:275368	5/16 (31%)
		zf-H2C2_2	339..364	CDD:316026	6/30 (20%)
		C2H2 Zn finger	355..372	CDD:275368	4/16 (25%)
		C2H2 Zn finger	419..439	CDD:275368	5/19 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100