DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and CG7368

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_001036599.1	Gene:	CG7368 / 39301	FlyBaseID:	FBgn0036179	Length:	530	Species:	Drosophila melanogaster

Alignment Length:	561	Identity:	104/561 - (18%)
Similarity:	186/561 - (33%)	Gaps:	170/561 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 LTQETTSFPEIIKLATQEEEGVTEPQELGGRNFFYPEIKIEEHELDTLPRIEILERSANTQENQD 156
            |.|.|||...::...|   ..||:....|..|   |:                       |:.|.
  Fly    17 LPQFTTSTAPLVSTVT---AAVTDVTVTGTNN---PQ-----------------------QQQQQ 52

  Fly   157 QLEGAARRLRKR-----------LKAEDGSSVDKDK--DEDGVEETAEPAPPKKRRGRPRKSDAA 208
            ...|::.|.:::           :.|..|||.:|.:  .:|.::       ..|..|.      .
  Fly    53 DAAGSSNRYQQQQQQVTHFGQATMTAGQGSSGNKFRGGQDDAIQ-------GDKYNGH------L 104

  Fly   209 VAPPQKPKEDIQLDLKAEELDEFVDEETDPDFSCLVPSDNSSEDDGGSDGFDSDSDFELDNGKQE 273
            ||..|:.::..|            .::|.   ...|...:::.....:|...:.:     :|:|:
  Fly   105 VASSQQQQQQQQ------------QQQTQ---YATVAYASATATSAATDALQAGT-----SGQQQ 149

  Fly   274 FAVLPKRTVVRPKKYKKRTKPAEPKVRMSRELLEQRKKQQEEYDVI-----IAKFFTSVLPCAIC 333
                    ..:..:.::.|.|.|....:...:|:|:..|...:..:     :|.:. |.||....
  Fly   150 --------QQQQMQQQQVTAPQELTQDLCNAILQQQVLQNTSWQTLTPGTTVADYL-SHLPANTL 205

  Fly   334 NLLVHNFTEMQRHHRLTHQVDPGYMMCCGRKFTQRKVLAEHVLVHWNP-------DHFKCSVCEK 391
            .|.:|:|.:              |.....:|..|:.|:.:   |...|       .....|:.::
  Fly   206 PLSLHHFLK--------------YSAETIKKENQQNVVLQ---VQTGPAIGINTLGTTTISIPQQ 253

  Fly   392 SFQNSRHLESHQQVHMDPAVKLTFSCDLCSKTFLSKTAIDYHKLNKHVPKSEFKFTCSECNKKFL 456
            :.|.:...:....:.:.....:|.:....:.|....:.....|..|              .||..
  Fly   254 AEQLTLQPQQQATLQVQTQAAVTATATTATATTAGGSGATSGKKKK--------------RKKRS 304

  Fly   457 TERKLK-----NHMSSMHDPESTIICDKCGKQMRTKIILKKHQELMHSDKPRPEPELQQCQICGA 516
            .:||.|     ..:.:..|.....:|.:|            |...       |||||
  Fly   305 KDRKTKLRPGEIRLGTALDGSPLYMCPEC------------HVAY-------PEPEL-------- 342

  Fly   517 WLKGMTGLKQHMKSIHVESAGEHRCHICAKVSPNARALRRHIYHNHECERKFKCTMCEKAFKRPQ 581
                   |:.|:...::|.  .:.|.||.........|.|| ..:|..||.:.||:|.|||||.:
  Fly   343 -------LEVHLVGHNLEK--RYVCDICQASLKRKDHLTRH-KQSHNPERPYICTVCLKAFKRKE 397

  Fly   582 ELKEHTSTHTGEVLYTCPNCPMTFFCSANMYKHRQRLHRAQ 622
            :|..|...|:||..:.|..|...|:...::.|| .|.|.|:
  Fly   398 QLSLHFVIHSGEKRHQCGECGKGFYRKDHLRKH-TRSHIAR 437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856	9/76 (12%)
		C2H2 Zn finger	330..351	CDD:275368	3/20 (15%)
		C2H2 Zn finger	360..378	CDD:275368	3/17 (18%)
		LIM	361..>400	CDD:295319	7/45 (16%)
		C2H2 Zn finger	386..406	CDD:275368	2/19 (11%)
		zf-C2H2_8	389..465	CDD:292531	10/80 (13%)
		C2H2 Zn finger	417..438	CDD:275368	2/20 (10%)
		C2H2 Zn finger	448..465	CDD:275368	5/21 (24%)
		C2H2 Zn finger	477..498	CDD:275368	3/20 (15%)
		C2H2 Zn finger	511..532	CDD:275368	2/20 (10%)
		C2H2 Zn finger	541..562	CDD:275368	6/20 (30%)
		C2H2 Zn finger	570..590	CDD:275368	10/19 (53%)
		C2H2 Zn finger	598..619	CDD:275368	6/20 (30%)
CG7368	NP_001036599.1	C2H2 Zn finger	330..350	CDD:275368	10/53 (19%)
		COG5048	356..>412	CDD:227381	22/56 (39%)
		C2H2 Zn finger	358..378	CDD:275368	6/20 (30%)
		zf-H2C2_2	370..395	CDD:290200	12/25 (48%)
		C2H2 Zn finger	386..406	CDD:275368	10/19 (53%)
		zf-H2C2_2	399..423	CDD:290200	8/23 (35%)
		zf-C2H2	412..434	CDD:278523	6/22 (27%)
		C2H2 Zn finger	414..434	CDD:275368	6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100