DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and ZNF470

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_001001668.3	Gene:	ZNF470 / 388566	HGNCID:	22220	Length:	717	Species:	Homo sapiens

Alignment Length:	574	Identity:	139/574 - (24%)
Similarity:	216/574 - (37%)	Gaps:	120/574 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 EFVSAAQSSLQETKVALMEDDPLTQE--TTSFPEIIKLATQEEEGVTEPQEL-GGRNFFYPEIKI 131
            |:::.||.||.: ||.|.....|...  ..|.|::|.|..||:    :|..: ||.|
Human    38 EWLNLAQRSLYK-KVMLENYRNLVSVGLCISKPDVISLLEQEK----DPWVIKGGMN-------- 89

  Fly   132 EEHELDTLPRIEILERSANTQENQDQLEGAARRLRKRLKAEDGSSVDKDKDEDGVEETAEPAPPK 196
                ....|.:|.:..:.:...|||..|                               |..||.
Human    90 ----RGLCPDLECVWVTKSLSLNQDIYE-------------------------------EKLPPA 119

  Fly   197 KRRGRPRKSDAAVAPPQKPKEDIQLDLKAEEL--DEFVDEETDPDFSCLVPSDNSSEDDGGSDGF 259
            ....|.:..|...:...|       :.|.|:|  .|.|:::|......:...|...|
Human   120 IIMERLKSYDLECSTLGK-------NWKCEDLFERELVNQKTHFRQETITHIDTLIE-------- 169

  Fly   260 DSDSDFELDNGKQEFAVLPKRTVVRPKKYKKRTKPAEPKV---------RMSRELLEQRKKQQEE 315
                  :.|:..:...|....|:    .|.|:..|.|.::         ..:..::::.|:.:.|
Human   170 ------KRDHSNKSGTVFHLNTL----SYIKQIFPMEERIFNFHTDKKSLKTHSVVKKHKQDRGE 224

  Fly   316 YDVIIAKFFTSVLPCAICNLLVHNFTEMQRHHRLTHQVDPGYMMCCGRKFTQRKVLAEHVLVHWN 380
                     ..:|.|..|..:....:.:..|.|:.....|...:.||:.|:|...||:|..:|..
Human   225 ---------KKLLKCNDCEKIFSKISTLTLHQRIHTGEKPYECIECGKAFSQSAHLAQHQRIHTG 280

  Fly   381 PDHFKCSVCEKSFQNSRHLESHQQVHMDPAVKLTFSCDLCSKTFLSKTAIDYHKLNKHVPKSEFK 445
            ...|:|:.|.|:|..:.||..||:||..   :..:.|..|:|.|.....:..|   :.|...|..
Human   281 EKPFECTECGKAFSQNAHLVQHQRVHTG---EKPYQCKQCNKAFSQLAHLAQH---QRVHTGEKP 339

  Fly   446 FTCSECNKKFLTERKLKNHMSSMHDPESTIICDKCGKQMRTKIILKKHQELMHS-DKPRPEPELQ 509
            :.|.||.|.|.....|.:| ..:|..:....|..|||..|....|.:|:...|: :||      .
Human   340 YECIECGKAFSDCSSLAHH-RRIHTGKRPYECIDCGKAFRQNASLIRHRRYYHTGEKP------F 397

  Fly   510 QCQICGAWLKGMTGLKQHMKSIHVESAGE--HRCHICAKVSPNARALRRHIYHNHECERKFKCTM 572
            .|..||.......||.|| |..|   .||  ::|::|.|...:..:|..| ...|..|:.::|.:
Human   398 DCIDCGKAFTDHIGLIQH-KRTH---TGERPYKCNVCGKAFSHGSSLTVH-QRIHTGEKPYECNI 457

  Fly   573 CEKAFKRPQELKEHTSTHTGEVLYTCPNCPMTFFCSANMYKHRQRLHRAQ--YE 624
            |||||.....|..|...||||..|.|..|...|..|.:: .|.||:|..:  ||
Human   458 CEKAFSHRGSLTLHQRVHTGEKPYECKECGKAFRQSTHL-AHHQRIHTGEKPYE 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071	5/10 (50%)
		FYDLN_acid	<191..268	CDD:302856	14/78 (18%)
		C2H2 Zn finger	330..351	CDD:275368	4/20 (20%)
		C2H2 Zn finger	360..378	CDD:275368	7/17 (41%)
		LIM	361..>400	CDD:295319	14/38 (37%)
		C2H2 Zn finger	386..406	CDD:275368	8/19 (42%)
		zf-C2H2_8	389..465	CDD:292531	22/75 (29%)
		C2H2 Zn finger	417..438	CDD:275368	5/20 (25%)
		C2H2 Zn finger	448..465	CDD:275368	6/16 (38%)
		C2H2 Zn finger	477..498	CDD:275368	7/20 (35%)
		C2H2 Zn finger	511..532	CDD:275368	8/20 (40%)
		C2H2 Zn finger	541..562	CDD:275368	5/20 (25%)
		C2H2 Zn finger	570..590	CDD:275368	8/19 (42%)
		C2H2 Zn finger	598..619	CDD:275368	7/20 (35%)
ZNF470	NP_001001668.3	KRAB	23..83	CDD:214630	16/49 (33%)
		KRAB	23..62	CDD:279668	9/24 (38%)
		Nuclear localization signal. /evidence=ECO:0000255	216..219		0/2 (0%)
		C2H2 Zn finger	230..250	CDD:275368	4/19 (21%)
		zf-H2C2_2	243..267	CDD:290200	6/23 (26%)
		COG5048	254..669	CDD:227381	86/276 (31%)
		C2H2 Zn finger	258..278	CDD:275368	7/19 (37%)
		zf-H2C2_2	270..295	CDD:290200	9/24 (38%)
		C2H2 Zn finger	286..306	CDD:275368	8/19 (42%)
		zf-H2C2_2	298..323	CDD:290200	10/27 (37%)
		C2H2 Zn finger	314..334	CDD:275368	5/22 (23%)
		zf-H2C2_2	326..350	CDD:290200	7/26 (27%)
		C2H2 Zn finger	342..362	CDD:275368	7/20 (35%)
		zf-H2C2_2	354..379	CDD:290200	7/25 (28%)
		C2H2 Zn finger	370..388	CDD:275368	7/17 (41%)
		Nuclear localization signal. /evidence=ECO:0000255	385..388		1/2 (50%)
		C2H2 Zn finger	399..419	CDD:275368	8/20 (40%)
		zf-H2C2_2	412..436	CDD:290200	10/27 (37%)
		C2H2 Zn finger	427..447	CDD:275368	5/20 (25%)
		zf-H2C2_2	439..464	CDD:290200	10/25 (40%)
		C2H2 Zn finger	455..475	CDD:275368	8/19 (42%)
		zf-H2C2_2	467..492	CDD:290200	10/24 (42%)
		C2H2 Zn finger	483..503	CDD:275368	7/20 (35%)
		zf-H2C2_2	495..520	CDD:290200	6/17 (35%)
		C2H2 Zn finger	511..531	CDD:275368	139/574 (24%)
		zf-H2C2_2	523..548	CDD:290200
		C2H2 Zn finger	539..559	CDD:275368
		zf-H2C2_2	551..575	CDD:290200
		C2H2 Zn finger	567..587	CDD:275368
		C2H2 Zn finger	595..615	CDD:275368
		zf-H2C2_2	607..632	CDD:290200
		C2H2 Zn finger	623..643	CDD:275368
		zf-H2C2_2	635..660	CDD:290200
		C2H2 Zn finger	651..671	CDD:275368
		zf-H2C2_2	663..688	CDD:290200
		C2H2 Zn finger	679..699	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910