DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and ZNF808

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_001034975.2	Gene:	ZNF808 / 388558	HGNCID:	33230	Length:	903	Species:	Homo sapiens

Alignment Length:	632	Identity:	133/632 - (21%)
Similarity:	222/632 - (35%)	Gaps:	175/632 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 VSDFHTLHEFVSAAQSSLQETKVALMEDDPLTQETTSFPEIIKLATQEEEGVTEPQELGGRNFFY 126
            :|..|.:.|.:|..|.:                     .|:|...|.:..   :...:|  :|.:
Human    65 ISSKHMMKEVLSTGQGN---------------------REVIHTGTLQRH---QSYHIG--DFCF 103

  Fly   127 PEIKIEEHELD-----------TLPRIEILERSANTQENQDQLEGAARRLRKRLKAEDGSSVDK- 179
            .||:.|.|.::           ..|..:|.:.:.:|.::..:..|     .|.:|.:.|||...
Human   104 QEIEKEIHNIEFQCQEDERNGHEAPTTKIKKLTGSTDQHDHRHAG-----NKPIKDQLGSSFYSH 163

  Fly   180 --------------DKDEDGVEETAEPAPPKKRRGRPR----------KSDAAVAPPQKPKEDIQ 220
                          ::.|....:.:..:..::...||:          ..::::.|   .|:::.
Human   164 LPELHIFQIKGEIANQLEKSTSDASSVSTSQRISCRPQIHISNNYGNNPLNSSLLP---QKQEVH 225

  Fly   221 LDLKAEELDEFVDEETDPDFSCLVPSDNSSEDDGGSDGFDSDSDFELDNGKQEFAVLPKRTVVRP 285
            :..|:     |...|:...|:|............|...:..|...:|.|.|| :....:|.....
Human   226 MREKS-----FPCNESGKAFNCSSLLRKHQIPHLGDKQYKCDVCGKLFNHKQ-YLACHRRCHTGE 284

  Fly   286 KKYKKRTKPAEPKVRMSRELLEQRKKQQEEYDVIIAKFFTSVLPCAICNLLVHNFTEMQRHHRLT 350
            |.||                                        |..|.......:.:..||||.
Human   285 KPYK----------------------------------------CKECGKSFSYKSSLTCHHRLH 309

  Fly   351 HQVDPGYMMCCGRKFTQRKVLAEHVLVHWNPDHFKCSVCEKSFQNSRHLESHQQVHMDPAVKLTF 415
            ..|.|.....||:.|.|...|..|..:|.....:||:.|.|:|....||..||::|  ..|| .:
Human   310 TGVKPYKCNECGKVFRQNSALVIHKAIHTGEKPYKCNECGKAFNQQSHLSRHQRLH--TGVK-PY 371

  Fly   416 SCDLCSKTFLSKTAIDYHKLNKHVPKSEFKFTCSECNKKFLTERKLKNHMSS------MHDPEST 474
            .|.:|.|.|...:.:..|   ..:...|..:.|:||.|.|       ||.||      :|..|..
Human   372 KCKICEKAFACHSYLANH---TRIHSGEKTYKCNECGKAF-------NHQSSLARHHILHTGEKP 426

  Fly   475 IICDKCGKQMRTKIILKKHQELMHSDKPRPEPELQQCQICGAWLKGMTGLKQHMKSIHVESAGE- 538
            ..|::|.|....|..|::|:.:...:||      .:|::|.......:.|.:| :.||   .||
Human   427 YKCEECDKVFSQKSTLERHKRIHTGEKP------YKCKVCDTAFTCNSQLARH-RRIH---TGEK 481

  Fly   539 -HRCHICAKVSPNARALRRH-------------------------IYHN--HECERKFKCTMCEK 575
             ::|:.|.|......:|..|                         :||.  |..|:.:|||:|.|
Human   482 TYKCNECRKTFSRRSSLLCHRRLHSGEKPYKCNQCGNTFRHRASLVYHRRLHTLEKSYKCTVCNK 546

  Fly   576 AFKRPQELKEHTSTHTGEVLYTCPNCPMTFFCSANMYKHRQRLHRAQ 622
            .|.|...|..||..||.:..|.|..|...|...:::.:|| |||..:
Human   547 VFMRNSVLAVHTRIHTAKKPYKCNECGKAFNQQSHLSRHR-RLHTGE 592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071	5/18 (28%)
		FYDLN_acid	<191..268	CDD:302856	11/86 (13%)
		C2H2 Zn finger	330..351	CDD:275368	6/20 (30%)
		C2H2 Zn finger	360..378	CDD:275368	6/17 (35%)
		LIM	361..>400	CDD:295319	13/38 (34%)
		C2H2 Zn finger	386..406	CDD:275368	8/19 (42%)
		zf-C2H2_8	389..465	CDD:292531	22/75 (29%)
		C2H2 Zn finger	417..438	CDD:275368	5/20 (25%)
		C2H2 Zn finger	448..465	CDD:275368	6/16 (38%)
		C2H2 Zn finger	477..498	CDD:275368	6/20 (30%)
		C2H2 Zn finger	511..532	CDD:275368	4/20 (20%)
		C2H2 Zn finger	541..562	CDD:275368	7/47 (15%)
		C2H2 Zn finger	570..590	CDD:275368	9/19 (47%)
		C2H2 Zn finger	598..619	CDD:275368	6/20 (30%)
ZNF808	NP_001034975.2	KRAB	24..64	CDD:307490
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	121..154		5/37 (14%)
		COG5048	206..585	CDD:227381	102/450 (23%)
		C2H2 Zn finger	233..253	CDD:275368	3/19 (16%)
		C2H2 Zn finger	261..281	CDD:275368	6/20 (30%)
		C2H2 Zn finger	289..309	CDD:275368	5/19 (26%)
		C2H2 Zn finger	317..337	CDD:275368	6/19 (32%)
		C2H2 Zn finger	345..365	CDD:275368	8/19 (42%)
		C2H2 Zn finger	373..393	CDD:275368	5/22 (23%)
		COG5048	397..839	CDD:227381	57/214 (27%)
		C2H2 Zn finger	401..421	CDD:275368	9/26 (35%)
		C2H2 Zn finger	429..449	CDD:275368	6/19 (32%)
		C2H2 Zn finger	457..477	CDD:275368	4/20 (20%)
		C2H2 Zn finger	485..505	CDD:275368	5/19 (26%)
		C2H2 Zn finger	513..533	CDD:275368	2/19 (11%)
		C2H2 Zn finger	541..561	CDD:275368	9/19 (47%)
		C2H2 Zn finger	569..589	CDD:275368	6/20 (30%)
		C2H2 Zn finger	597..617	CDD:275368
		C2H2 Zn finger	625..645	CDD:275368
		C2H2 Zn finger	653..673	CDD:275368
		C2H2 Zn finger	681..701	CDD:275368
		C2H2 Zn finger	709..729	CDD:275368
		C2H2 Zn finger	737..757	CDD:275368
		C2H2 Zn finger	765..785	CDD:275368
		C2H2 Zn finger	793..813	CDD:275368
		SFP1	<816..893	CDD:227516
		C2H2 Zn finger	821..841	CDD:275368
		C2H2 Zn finger	849..869	CDD:275368
		C2H2 Zn finger	877..897	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910