DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and ZNF728

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_001254645.1	Gene:	ZNF728 / 388523	HGNCID:	32463	Length:	622	Species:	Homo sapiens

Alignment Length:	361	Identity:	96/361 - (26%)
Similarity:	147/361 - (40%)	Gaps:	71/361 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   330 CAICNLLVH-------NFTEMQRHHR-------LTH-QVDPGYMMC----CGRKFTQRKVLAEHV 375
            |.:.:|..|       |..:.:.|.:       ||: ::..|...|    ||:.|::..:|.:|.
Human   183 CMLSHLSQHKRIYTRENSYKSEEHGKAFNWSSALTYKRIHTGEKPCKCEECGKAFSKFSILTKHK 247

  Fly   376 LVHWNPDHFKCSVCEKSFQNSRHLESHQQVHMDPAVKLTFSCDLCSKTFLSKTAIDYHKLNKHVP 440
            ::|....|:||..|.|:|..|..|..|::.|   |.:..:.|:.|.|.|...:.:..||.   :.
Human   248 VIHTGEKHYKCEECGKAFTRSSSLIEHKRSH---AGEKPYKCEECGKAFSKASTLTAHKT---IH 306

  Fly   441 KSEFKFTCSECNKKFLTERKLKNHMSSMHDPESTIICDKCGKQMRTKIILKKHQELMHSDKPRPE 505
            ..|..:.|.||.|.|.....|..| ..:|..|....|::|||.......|.||:.:...:||
Human   307 AGEKPYKCEECGKAFNRSSNLMEH-KRIHTGEKPCKCEECGKAFGNFSTLTKHKVIHTGEKP--- 367

  Fly   506 PELQQCQICGAWLKGMTGLKQHMKSIHVESAGE--HRCHICAKVSPNARALRRH-IYHN------ 561
               .:|:.||......:.|.:| |.||   ||:  ::|..|.|....:..|.:| |.|.
Human   368 ---YKCEECGKAFSWPSSLTEH-KRIH---AGDKPYKCEECGKTFKWSSTLTKHKIIHTGEKPYK 425

  Fly   562 -HEC-------------------ERKFKCTMCEKAFKRPQELKEHTSTHTGEVLYTCPNCPMTFF 606
             .||                   |:.:||..|.|.|.....|..|.:.|.||.||.|..|...|.
Human   426 CEECGKAFTTFSSLTKHKVIHTGEKHYKCEECGKVFSWSSSLTTHKAIHAGEKLYKCEECGKAFK 490

  Fly   607 CSANMYKHRQRLHRAQ-----YEADKNQPKPPNILK 637
            .|:|:.:|: |:|..:     .|..|...|..|:.|
Human   491 WSSNLMEHK-RIHTGEKPYKCEECGKAFSKVANLTK 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856
		C2H2 Zn finger	330..351	CDD:275368	6/34 (18%)
		C2H2 Zn finger	360..378	CDD:275368	6/21 (29%)
		LIM	361..>400	CDD:295319	13/38 (34%)
		C2H2 Zn finger	386..406	CDD:275368	7/19 (37%)
		zf-C2H2_8	389..465	CDD:292531	21/75 (28%)
		C2H2 Zn finger	417..438	CDD:275368	6/20 (30%)
		C2H2 Zn finger	448..465	CDD:275368	6/16 (38%)
		C2H2 Zn finger	477..498	CDD:275368	7/20 (35%)
		C2H2 Zn finger	511..532	CDD:275368	6/20 (30%)
		C2H2 Zn finger	541..562	CDD:275368	7/28 (25%)
		C2H2 Zn finger	570..590	CDD:275368	6/19 (32%)
		C2H2 Zn finger	598..619	CDD:275368	7/20 (35%)
ZNF728	NP_001254645.1	KRAB	4..64	CDD:214630
		KRAB	4..43	CDD:279668
		C2H2 Zn finger	146..167	CDD:275370
		C2H2 Zn finger	175..195	CDD:275368	3/11 (27%)
		COG5048	186..583	CDD:227381	95/358 (27%)
		C2H2 Zn finger	230..250	CDD:275368	5/19 (26%)
		C2H2 Zn finger	258..278	CDD:275368	7/19 (37%)
		C2H2 Zn finger	286..306	CDD:275368	6/22 (27%)
		C2H2 Zn finger	314..334	CDD:275368	7/20 (35%)
		zf-H2C2_2	326..349	CDD:290200	8/23 (35%)
		C2H2 Zn finger	342..362	CDD:275368	7/19 (37%)
		zf-H2C2_2	355..378	CDD:290200	8/28 (29%)
		C2H2 Zn finger	370..390	CDD:275368	6/20 (30%)
		zf-H2C2_2	382..406	CDD:290200	10/27 (37%)
		C2H2 Zn finger	398..418	CDD:275368	6/19 (32%)
		zf-H2C2_2	411..435	CDD:290200	6/23 (26%)
		C2H2 Zn finger	426..446	CDD:275368	2/19 (11%)
		C2H2 Zn finger	454..474	CDD:275368	6/19 (32%)
		C2H2 Zn finger	482..502	CDD:275368	7/20 (35%)
		zf-H2C2_2	494..518	CDD:290200	6/24 (25%)
		C2H2 Zn finger	510..530	CDD:275368	5/16 (31%)
		zf-H2C2_2	522..545	CDD:290200	2/4 (50%)
		C2H2 Zn finger	538..558	CDD:275368
		zf-H2C2_2	551..574	CDD:290200
		C2H2 Zn finger	566..586	CDD:275368
		C2H2 Zn finger	594..614	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910