DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and CG7386

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_648036.1	Gene:	CG7386 / 38719	FlyBaseID:	FBgn0035691	Length:	662	Species:	Drosophila melanogaster

Alignment Length:	707	Identity:	145/707 - (20%)
Similarity:	268/707 - (37%)	Gaps:	149/707 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 CLLCMCEYPAMMGDYIDVHSARGDQLEVTTIVNQHFPVQISKESDE------RICGRCWKIVSDF 65
            ||.|:          :.:....|..|.|...:.|......|.::|:      .:|.:|:..::|.
  Fly    11 CLTCL----------VHLKHGAGHDLFVVPDLFQKLRACTSFDADQNDGFPRNLCTQCFTKLNDL 65

  Fly    66 HTLHEFVSAAQSSLQETKVALMEDDPLTQETTSFPEIIKLATQEEEGVTEPQELGGRNFFYP--- 127
            |...|..:.:...|:|.         :|.:......:.:....:.|....|:|...   |.|
  Fly    66 HDFRELCAESIKRLKEM---------MTSQRNMPMGVFESIADDSEAPERPEEPAS---FDPLLN 118

  Fly   128 -EIKIEEHELDTLPRIEILERSANTQENQDQLEGAARRLRKRLKAEDGSSVDKDKDEDGVEETAE 191
             ::::.::|.|....:|.:::... :.::||.|      .....||.....::.|:.:|.....|
  Fly   119 NKLEMIDNEEDVFKLLEKVDKELE-EHSRDQSE------EHFSSAEHNGLEEEKKESEGFNSDDE 176

  Fly   192 PAPPKKRRGRPRKS-----DAAVAPPQKPKEDIQLDLKAEELDEFVDEETD--PDFSCLVPSDNS 249
            .|..::|....::.     ..::. .||.|       |..:.:|.:....|  | |.|
  Fly   177 QAMGQRRIANDKRKLFRLMSCSIC-QQKFK-------KQSKFEEHMKHHNDLLP-FQC------- 225

  Fly   250 SEDDGGSDGFDSDSDFELD----NGKQE-------------FAVLPKRTVVRPKKYKKRTKPAEP 297
             :::....||.:.....|.    :.|:|             |:.| :...:..||...:.:...|
  Fly   226 -QEESCRKGFTTAGALRLHVDYAHSKKEDTVPCTVEGCQLVFSRL-RLLTIHLKKVHNQARVIAP 288

  Fly   298 K---------------VRMSRELLEQRKKQQEEYDVIIAKFFTSVLPCAICNLLVHNFTEMQRHH 347
            :               |.|.:.:.....::..             .||.||....: .....::|
  Fly   289 RGEQSCKECGVVFRCPVAMKKHMYTHTGEELP-------------YPCTICGKGFY-INSALKNH 339

  Fly   348 RLTHQVDPGYMMC--CGRKFTQRKVLAEHVLVHWNPDHFKCSVCEKSFQNSRHLESHQQVHMDPA 410
            .|.|.....| :|  ||.:.|.|:..::|:|:|...:.|||.:|:.:....|.||||.:: :...
  Fly   340 LLRHAGIKNY-VCQYCGVRKTTRQEWSKHILIHTQRNQFKCRICDYATHTKRVLESHVKI-VHEK 402

  Fly   411 VKLTFSCDLCSKTFLSKTAIDYHKLNKHVPKSEFKFTCSECNKKFLTERKLKNHMSSMHD----- 470
            :: .|:|..|.|||....|...|:: .|.  .|.:..|..|:||||....|.||: .:|:
  Fly   403 IR-NFACQYCGKTFGKAYACKIHEM-AHT--GEKRCECKVCDKKFLHSESLNNHL-KIHEKSVER 462

  Fly   471 -----PESTIICDKCGKQMRTKIILKKHQELMHSDKPRPEPELQQCQICGAWLKGMTGLKQHMKS 530
                 .:..:..|....|:.:..:||.:.|.:.|....|. .::|..:  |.|.| |.:....:.
  Fly   463 ALETYKQVQVNGDASDTQVDSHQLLKVYAESVASIPKNPR-RVEQVDV--ALLAG-TAVNPTDEI 523

  Fly   531 IHVESAGEHRCHICAKVSPNARALRRHIYHNHECERKFKCTMCEKAFKRPQELKEHTSTHTGEVL 595
            ..|:..|.:.|..|::...:...::||....||..:.|:|..|.:.|...|.:|:|...||||..
  Fly   524 QFVQKEGMYLCPSCSQGFKSIGNMKRHYKSVHEKVKDFECRFCSRRFANSQSVKQHEWIHTGEKP 588

  Fly   596 YTCPNCPMTFFCSANMYKHRQRLHRAQYEADKNQPKPPNILKISRNASTQNKPKQEI 652
            :.|..|...|...|.:.:| |::|      |:...||         ...:|..||::
  Fly   589 FECKTCGNRFRQVAALIRH-QKVH------DEKPAKP---------LGERNDRKQKV 629

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071	15/79 (19%)
		FYDLN_acid	<191..268	CDD:302856	14/83 (17%)
		C2H2 Zn finger	330..351	CDD:275368	5/20 (25%)
		C2H2 Zn finger	360..378	CDD:275368	7/19 (37%)
		LIM	361..>400	CDD:295319	12/38 (32%)
		C2H2 Zn finger	386..406	CDD:275368	7/19 (37%)
		zf-C2H2_8	389..465	CDD:292531	24/75 (32%)
		C2H2 Zn finger	417..438	CDD:275368	7/20 (35%)
		C2H2 Zn finger	448..465	CDD:275368	8/16 (50%)
		C2H2 Zn finger	477..498	CDD:275368	5/20 (25%)
		C2H2 Zn finger	511..532	CDD:275368	4/20 (20%)
		C2H2 Zn finger	541..562	CDD:275368	4/20 (20%)
		C2H2 Zn finger	570..590	CDD:275368	6/19 (32%)
		C2H2 Zn finger	598..619	CDD:275368	6/20 (30%)
CG7386	NP_648036.1	zf-AD	10..81	CDD:214871	15/79 (19%)
		C2H2 Zn finger	197..217	CDD:275368	5/27 (19%)
		C2H2 Zn finger	294..314	CDD:275368	2/19 (11%)
		C2H2 Zn finger	323..343	CDD:275368	5/20 (25%)
		C2H2 Zn finger	351..371	CDD:275368	7/19 (37%)
		C2H2 Zn finger	379..400	CDD:275368	7/21 (33%)
		C2H2 Zn finger	408..428	CDD:275368	7/20 (35%)
		C2H2 Zn finger	436..456	CDD:275368	9/20 (45%)
		C2H2 Zn finger	534..555	CDD:275368	4/20 (20%)
		C2H2 Zn finger	563..583	CDD:275368	6/19 (32%)
		zf-H2C2_2	575..600	CDD:290200	9/24 (38%)
		C2H2 Zn finger	591..611	CDD:275368	6/20 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910