DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and CG4707

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_611944.1	Gene:	CG4707 / 37935	FlyBaseID:	FBgn0035036	Length:	673	Species:	Drosophila melanogaster

Alignment Length:	690	Identity:	323/690 - (46%)
Similarity:	427/690 - (61%)	Gaps:	79/690 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 CLLCMCEYPAMMGDYIDVHSARGDQLEVTTIVNQHFPVQ--ISKESDERICGRCWKIVSDFHTLH 69
            |:||:....|..|    :.|..|.:|.:...:::||...  ::...|..:|..||..||.|...|
  Fly     4 CVLCLDSSNAGYG----LQSEEGVRLNIRATIHKHFAFSEVLTAGGDAEVCRECWNCVSSFEEFH 64

  Fly    70 EFVSAAQSSLQETKVALMEDDPLTQETTSFPEIIKLATQEEEGVTEP---QELG--GRNFFYP-E 128
            :.||.....               :.:.|..|.|:...|.||.:..|   .||.  ...||.| |
  Fly    65 QRVSCLHRQ---------------RSSDSKSEPIEFCGQTEEAIINPLYSVELDALAEAFFAPSE 114

  Fly   129 IKIEEHELDTLPRIEILERSANTQENQDQLEGAARRL----------RKRLKAEDGSSVDKDKD- 182
            :|:|.:||:.||::|:||....|     ::..|.:||          ::|:|.|  ..||.|.|
  Fly   115 VKVEVNELEPLPKVELLEDPVKT-----EIRTAPKRLGVPNEGSPHSKRRIKNE--LPVDSDSDA 172

  Fly   183 -------EDGVEETAEPAPPKK-----------RRGRPRKSDAAVAPPQKPKEDIQLDLKAEELD 229
                   .|....:..||...:           |||||.|:....||  .||:    :|.:|:.:
  Fly   173 PLADFLNSDSKRSSVGPAKNSEANKGRQLRRSARRGRPPKAKPESAP--SPKK----ELDSEDGE 231

  Fly   230 EFVDEETDPDF---SCLVPSDNSSEDDGGSDGFDSDSDFELDNGKQEFAVLPKRTVVRPKKYKKR 291
            |...:..|.:|   ..::.:|:||.....|.|.|||........::.:|.:|||.||:||||:||
  Fly   232 ENARDNNDMEFVAPEAVLGTDDSSSSSSESSGEDSDHSLPDIEPEERYAEIPKRVVVKPKKYRKR 296

  Fly   292 TKPAEPKVRMSRELLEQRKKQQEEYDVIIAKFFTSVLPCAICNLLVHNFTEMQRHHRLTHQVDPG 356
            .||..|.||:|||.:|:||.||:|||.||.:||.. .||::|||||.||.:|:||.|::|.::.|
  Fly   297 EKPLVPPVRLSREEIERRKLQQDEYDEIILQFFKK-FPCSLCNLLVQNFADMRRHQRVSHNIESG 360

  Fly   357 YMMCCGRKFTQRKVLAEHVLVHWNPDHFKCSVCEKSFQNSRHLESHQQVHMDPAVKL------TF 415
            |:.||||||..||.||||||||.|||||.||.|.:.||:||.||.|:|.|.:|.||.      .:
  Fly   361 YIECCGRKFHLRKALAEHVLVHKNPDHFMCSQCGRVFQDSRALEVHEQTHTNPEVKAEPKEKRIY 425

  Fly   416 SCDLCSKTFLSKTAIDYHKLNKHVPKSEFKFTCSECNKKFLTERKLKNHMSSMHDPESTIICDKC 480
            .|:.|.|:|.:|.|::||.::|||||||||::|.|||||..||||||.|:..|||||:.||||||
  Fly   426 QCEKCPKSFTTKAAMEYHDVSKHVPKSEFKYSCPECNKKIPTERKLKEHLRYMHDPEAAIICDKC 490

  Fly   481 GKQMRTKIILKKHQELMHSDKPRPEPELQQCQICGAWLKGMTGLKQHMKSIHVESAGEHRCHICA 545
            ||.:|::..||||.||.||:||||:|:..||:|||.||:.::|||||||::|.....|||||||.
  Fly   491 GKTLRSQTNLKKHHELEHSEKPRPKPDPVQCEICGTWLRHLSGLKQHMKTVHEPPGDEHRCHICN 555

  Fly   546 KVSPNARALRRHIYHNHECERKFKCTMCEKAFKRPQELKEHTSTHTGEVLYTCPNCPMTFFCSAN 610
            |.|.|:|||:|||||||.|||||||.||||||||||:|:||||||||||||||||||||||.:||
  Fly   556 KTSTNSRALKRHIYHNHLCERKFKCGMCEKAFKRPQDLREHTSTHTGEVLYTCPNCPMTFFSNAN 620

  Fly   611 MYKHRQRLHRAQYEADKNQPKPPNILKISRNASTQNKPKQ 650
            |||||||||||::|||:.:|.||||:|||:.|:|..|.:|
  Fly   621 MYKHRQRLHRAEWEADRKKPLPPNIMKISQGATTAMKKRQ 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071	20/75 (27%)
		FYDLN_acid	<191..268	CDD:302856	25/90 (28%)
		C2H2 Zn finger	330..351	CDD:275368	12/20 (60%)
		C2H2 Zn finger	360..378	CDD:275368	14/17 (82%)
		LIM	361..>400	CDD:295319	27/38 (71%)
		C2H2 Zn finger	386..406	CDD:275368	11/19 (58%)
		zf-C2H2_8	389..465	CDD:292531	42/81 (52%)
		C2H2 Zn finger	417..438	CDD:275368	8/20 (40%)
		C2H2 Zn finger	448..465	CDD:275368	12/16 (75%)
		C2H2 Zn finger	477..498	CDD:275368	13/20 (65%)
		C2H2 Zn finger	511..532	CDD:275368	13/20 (65%)
		C2H2 Zn finger	541..562	CDD:275368	15/20 (75%)
		C2H2 Zn finger	570..590	CDD:275368	16/19 (84%)
		C2H2 Zn finger	598..619	CDD:275368	18/20 (90%)
CG4707	NP_611944.1	zf-AD	3..73	CDD:285071	20/72 (28%)
		C2H2 Zn finger	334..355	CDD:275368	12/20 (60%)
		LIM	<361..407	CDD:295319	31/45 (69%)
		C2H2 Zn finger	365..382	CDD:275368	13/16 (81%)
		C2H2 Zn finger	390..410	CDD:275368	11/19 (58%)
		C2H2 Zn finger	427..443	CDD:275368	6/15 (40%)
		C2H2 Zn finger	458..476	CDD:275368	13/17 (76%)
		C2H2 Zn finger	487..507	CDD:275368	12/19 (63%)
		C2H2 Zn finger	521..540	CDD:275368	12/18 (67%)
		C2H2 Zn finger	551..572	CDD:275368	15/20 (75%)
		C2H2 Zn finger	580..600	CDD:275368	16/19 (84%)
		C2H2 Zn finger	608..629	CDD:275368	18/20 (90%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471722
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3C5T3
Homologene	1	1.000	-	-		H134721
Inparanoid	1	1.050	243	1.000	Inparanoid score	I5669
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000909
OrthoInspector	1	1.000	-	-		mtm14827
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24403
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.890