DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and ZNF568

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_940941.2	Gene:	ZNF568 / 374900	HGNCID:	25392	Length:	644	Species:	Homo sapiens

Alignment Length:	661	Identity:	150/661 - (22%)
Similarity:	236/661 - (35%)	Gaps:	137/661 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 AQSSLQETKVALMEDDPLTQETTSFPEIIKLATQEEEGVTEPQELGGRNFFYPEIKIEEHELDTL 139
            :|||:.......||......|..::.......::|||..|.|.|         .:..::..:|.
Human     3 SQSSVISNSCVTMERLSHMMERKAWCSQESALSEEEEDTTRPLE---------TVTFKDVAVDL- 57

  Fly   140 PRIEILERSANTQENQDQLEGAARRLRKRLKAED-------GSSVDKDKDEDGVEETAEP-APPK 196
                       |||..:|::.|.|.|.:.:..|:       |..|.|......:|:..|| ...:
Human    58 -----------TQEEWEQMKPAQRNLYRDVMLENYSNLVTVGCQVTKPDVIFKLEQEEEPWVMEE 111

  Fly   197 KRRGR------------PRKSDAAVAPPQKPKEDIQLDLKAEELDEFVDEETDPDFSCLVPSDNS 249
            :..||            .::.:..|.......:.|.:..|..|..:..  :..|..|.:|.|..|
Human   112 EMFGRHCPEVWEVDEQIKKQQETLVRKVTSISKKILIKEKVIECKKVA--KIFPLSSDIVTSRQS 174

  Fly   250 SEDDGGSDGFDSDSDFELDNGKQE---------------------FAVLP------------KRT 281
            ..|   .|..|...:..||..:.|                     :.|.|            |..
Human   175 FYD---CDSLDKGLEHNLDLLRYEKGCVREKQSNEFGKPFYHCASYVVTPFKCNQCGQDFSHKFD 236

  Fly   282 VVRPKKYKKRTKPAEPKVRMSRELLEQRKKQQEEYDVII-AKFFTSVLP--CAICNLLVHNFTEM 343
            ::|.::.....||.|.|        |..|....:.::|. .|..|...|  |..|.......:.:
Human   237 LIRHERIHAGEKPYECK--------ECGKAFSRKENLITHQKIHTGEKPYKCNECGKAFIQMSNL 293

  Fly   344 QRHHRLTHQVDPGYMMCCGRKFTQRKVLAEHVLVHWNPDHFKCSVCEKSFQNSRHLESHQQVHMD 408
            .||||:.....|.....|.:.|:|:..|.||..:|.....::|..|.|||...::|..|:::|..
Human   294 IRHHRIHTGEKPYACKDCWKAFSQKSNLIEHERIHTGEKPYECKECGKSFSQKQNLIEHEKIHTG 358

  Fly   409 PAVKLTFSCDLCSKTFLSKTAIDYHKLNKHVPKSEFK--------------------------FT 447
               :..::|:.|.:.|...:::..| :..|..:..:|                          :.
Human   359 ---EKPYACNECGRAFSRMSSVTLH-MRSHTGEKPYKCNKCGKAFSQCSVFIIHMRSHTGEKPYV 419

  Fly   448 CSECNKKFLTERKLKNHMSSMHDPESTIICDKCGKQMRTKIILKKHQELMHSDKPRPEPELQQCQ 512
            ||||.|.|.....|..||.: |..|....|.:|||....|..|..||::...:||      .:|.
Human   420 CSECGKAFSQSSSLTVHMRN-HTAEKPYECKECGKAFSRKENLITHQKIHTGEKP------YECS 477

  Fly   513 ICGAWLKGMTGLKQHMKSIHVESAGE--HRCHICAKVSPNARALRRHIYHNHECERKFKCTMCEK 575
            .||.....|:.|.:|.: ||   .||  :.|.:|.|.......|..| ...|..|:.:.|..|.|
Human   478 ECGKAFIQMSNLIRHQR-IH---TGEKPYACTVCGKAFSQKSNLTEH-EKIHTGEKPYHCNQCGK 537

  Fly   576 AFKRPQELKEHTSTHTGEVLYTCPNCPMTFFCSANMYKH-RQRLHRAQYEADK--NQPKPPNILK 637
            ||.:.|.|.||...||||..:.|..|...|...:::..| |.......||.:|  ......::|.
Human   538 AFSQRQNLLEHEKIHTGEKPFKCNECGKAFSRISSLTLHVRSHTGEKPYECNKCGKAFSQCSLLI 602

  Fly   638 ISRNASTQNKP 648
            |...:.|..||
Human   603 IHMRSHTGEKP 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071	3/5 (60%)
		FYDLN_acid	<191..268	CDD:302856	16/89 (18%)
		C2H2 Zn finger	330..351	CDD:275368	6/20 (30%)
		C2H2 Zn finger	360..378	CDD:275368	6/17 (35%)
		LIM	361..>400	CDD:295319	12/38 (32%)
		C2H2 Zn finger	386..406	CDD:275368	7/19 (37%)
		zf-C2H2_8	389..465	CDD:292531	20/101 (20%)
		C2H2 Zn finger	417..438	CDD:275368	4/20 (20%)
		C2H2 Zn finger	448..465	CDD:275368	7/16 (44%)
		C2H2 Zn finger	477..498	CDD:275368	8/20 (40%)
		C2H2 Zn finger	511..532	CDD:275368	6/20 (30%)
		C2H2 Zn finger	541..562	CDD:275368	5/20 (25%)
		C2H2 Zn finger	570..590	CDD:275368	9/19 (47%)
		C2H2 Zn finger	598..619	CDD:275368	5/21 (24%)
ZNF568	NP_940941.2	KRAB	48..102	CDD:214630	12/65 (18%)
		KRAB	48..87	CDD:279668	9/50 (18%)
		C2H2 Zn finger	224..244	CDD:275368	2/19 (11%)
		zf-H2C2_2	236..261	CDD:290200	7/32 (22%)
		COG5048	248..634	CDD:227381	102/390 (26%)
		C2H2 Zn finger	252..272	CDD:275368	5/27 (19%)
		zf-H2C2_2	264..289	CDD:290200	6/24 (25%)
		C2H2 Zn finger	280..300	CDD:275368	6/19 (32%)
		zf-H2C2_2	292..317	CDD:290200	7/24 (29%)
		C2H2 Zn finger	308..328	CDD:275368	6/19 (32%)
		zf-H2C2_2	320..345	CDD:290200	9/24 (38%)
		C2H2 Zn finger	336..356	CDD:275368	7/19 (37%)
		zf-H2C2_2	348..373	CDD:290200	6/27 (22%)
		C2H2 Zn finger	364..384	CDD:275368	4/20 (20%)
		zf-H2C2_2	380..401	CDD:290200	3/21 (14%)
		C2H2 Zn finger	392..412	CDD:275368	0/19 (0%)
		zf-H2C2_2	408..429	CDD:290200	6/20 (30%)
		C2H2 Zn finger	420..440	CDD:275368	9/20 (45%)
		zf-H2C2_2	432..457	CDD:290200	9/25 (36%)
		C2H2 Zn finger	448..468	CDD:275368	8/19 (42%)
		zf-H2C2_2	460..485	CDD:290200	8/30 (27%)
		C2H2 Zn finger	476..496	CDD:275368	6/20 (30%)
		zf-H2C2_2	488..513	CDD:290200	9/28 (32%)
		C2H2 Zn finger	504..524	CDD:275368	5/20 (25%)
		zf-H2C2_2	516..541	CDD:290200	9/25 (36%)
		C2H2 Zn finger	532..552	CDD:275368	9/19 (47%)
		zf-H2C2_2	544..569	CDD:290200	10/24 (42%)
		C2H2 Zn finger	560..580	CDD:275368	5/19 (26%)
		zf-H2C2_2	572..597	CDD:290200	5/24 (21%)
		C2H2 Zn finger	588..608	CDD:275368	3/19 (16%)
		zf-H2C2_2	601..625	CDD:290200	5/13 (38%)
		C2H2 Zn finger	616..636	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910