DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and ZNF710

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_005254963.1	Gene:	ZNF710 / 374655	HGNCID:	25352	Length:	679	Species:	Homo sapiens

Alignment Length:	636	Identity:	146/636 - (22%)
Similarity:	223/636 - (35%)	Gaps:	171/636 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 IIKLATQEEEGVTEPQELGGRNF----FYPEIKIE-------EHE---------------LDTLP 140
            ::.||.....|:....||.|...    |||::..|       |.|               |:...
Human    16 VLSLAQAAVLGLVSENELFGATISAEAFYPDLGPELSGAAMGEPEPPGPDVYQLACNGRALEEPA 80

  Fly   141 RIEILERSANTQENQDQLEGAARRLRKRLKAE----------DGSSVDKDKDEDGVEETAEPA-- 193
            ..|:||..|..:::..:......||..::|.|          :.|....|||....|..||.|
Human    81 EEEVLEVEAACEKHTRRKTRPPVRLVPKVKFEKVEEEEQEVYEVSVPGDDKDAGPAEAPAEAASG 145

  Fly   194 ---------------------PPKKRRGRPR--KSDAAVAP--PQKPKEDIQLDLKAEELDEFVD 233
                                 .|:..|..||  :.:..|||  |..|         |...|.|.:
Human   146 GCDALVQSSAVKMIDLSAFSRKPRTLRHLPRTPRPELNVAPYDPHFP---------APARDGFPE 201

  Fly   234 EE-----------------------TDPDFSCLVPSDNSSEDDGGSDGF--DSDSDFELDNGKQE 273
            ..                       :||:    .||..|.|......||  ...|:||.|....
Human   202 PSMALPGPEALPTECGFEPPHLAPLSDPE----APSMESPEPVKPEQGFVWQEASEFEADTAGS- 261

  Fly   274 FAVLPKRTVVRPKKYKKRTKPAEPKVRMSRELLEQRKKQQEEYDVIIAKFFTSVLPCAICNLLVH 338
                   ||.|.|  |.:....:..|::....|.:...:|:.:.            |.:|.   .
Human   262 -------TVERHK--KAQLDRLDINVQIDDSYLVEAGDRQKRWQ------------CRMCE---K 302

  Fly   339 NFTEMQRHHRLTH-----QVDPGYMMCCGRKFTQRKVLAEHVLVHWNPDHFKCSVCEKSFQNSRH 398
            ::|  .:::.:||     .:.|.....|.:.|.|...|..|:|.|......||.||.|:|..:.|
Human   303 SYT--SKYNLVTHILGHNGIKPHSCPHCSKLFKQPSHLQTHLLTHQGTRPHKCQVCHKAFTQTSH 365

  Fly   399 LESHQQVHMDPAVKLTFSCDLCSKTFLSKTAIDYH-----------------------KLNKHVP 440
            |:.|..:|.:  || .:||..|.:.|...:.:..|                       :|.:|:.
Human   366 LKRHMLLHSE--VK-PYSCHFCGRGFAYPSELKAHEVKHESGRCHVCVECGLDFSTLTQLKRHLA 427

  Fly   441 KSE--FKFTCSECNKKFLTERKLKNHMSSMHDPESTIICDKCGKQMRTKIILKKHQELMHSDKPR 503
            ..:  ..:.|.||:|.|....:|:|||.. |......:|.:||.:......||:| .|.|.....
Human   428 SHQGPTLYQCLECDKSFHYRSQLQNHMLK-HQNVRPFVCTECGMEFSQIHHLKQH-SLTHKGVKE 490

  Fly   504 PEPELQQCQICGAWLKGMTGLKQHMKSIHVESAGEHRCHICAKVSPNARALRRHIYHNHECERKF 568
                 .:|::||........:|:|| .||. |...::||||.|.....:.|:.|:. .|...:.|
Human   491 -----FKCEVCGREFTLQANMKRHM-LIHT-SVRPYQCHICFKTFVQKQTLKTHMI-VHSPVKPF 547

  Fly   569 KCTMCEKAFKRPQELKEHTSTHTGEVLYTCPNCPMTFFCSANMYKHRQRLH 619
            ||.:|.|:|.|...|..|...|.|...:.||.|...|....|:.:|.:..|
Human   548 KCKVCGKSFNRMYNLLGHMHLHAGSKPFKCPYCSSKFNLKGNLSRHMKVKH 598

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856	25/128 (20%)
		C2H2 Zn finger	330..351	CDD:275368	3/20 (15%)
		C2H2 Zn finger	360..378	CDD:275368	6/17 (35%)
		LIM	361..>400	CDD:295319	14/38 (37%)
		C2H2 Zn finger	386..406	CDD:275368	8/19 (42%)
		zf-C2H2_8	389..465	CDD:292531	23/100 (23%)
		C2H2 Zn finger	417..438	CDD:275368	5/43 (12%)
		C2H2 Zn finger	448..465	CDD:275368	7/16 (44%)
		C2H2 Zn finger	477..498	CDD:275368	7/20 (35%)
		C2H2 Zn finger	511..532	CDD:275368	6/20 (30%)
		C2H2 Zn finger	541..562	CDD:275368	7/20 (35%)
		C2H2 Zn finger	570..590	CDD:275368	7/19 (37%)
		C2H2 Zn finger	598..619	CDD:275368	6/20 (30%)
ZNF710	XP_005254963.1	C2H2 Zn finger	297..317	CDD:275368	5/24 (21%)
		C2H2 Zn finger	325..345	CDD:275368	6/19 (32%)
		COG5048	<335..593	CDD:227381	74/270 (27%)
		zf-H2C2_2	337..362	CDD:290200	10/24 (42%)
		C2H2 Zn finger	353..373	CDD:275368	8/19 (42%)
		zf-H2C2_2	365..390	CDD:290200	10/27 (37%)
		C2H2 Zn finger	381..401	CDD:275368	4/19 (21%)
		C2H2 Zn finger	409..429	CDD:275368	2/19 (11%)
		zf-C2H2	435..457	CDD:278523	9/22 (41%)
		C2H2 Zn finger	437..457	CDD:275368	9/20 (45%)
		zf-H2C2_2	450..474	CDD:290200	8/24 (33%)
		C2H2 Zn finger	465..485	CDD:275368	7/20 (35%)
		C2H2 Zn finger	493..513	CDD:275368	6/20 (30%)
		zf-H2C2_2	505..530	CDD:290200	11/26 (42%)
		C2H2 Zn finger	521..541	CDD:275368	7/20 (35%)
		zf-H2C2_2	534..558	CDD:290200	9/24 (38%)
		C2H2 Zn finger	549..569	CDD:275368	7/19 (37%)
		C2H2 Zn finger	577..596	CDD:275368	6/18 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910