DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and CG15073

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_611362.2	Gene:	CG15073 / 37155	FlyBaseID:	FBgn0034379	Length:	580	Species:	Drosophila melanogaster

Alignment Length:	681	Identity:	179/681 - (26%)
Similarity:	276/681 - (40%)	Gaps:	187/681 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 CLLCMCEYPAMMGDYIDVHSARGDQLEVTTIVNQHFPVQISKESDER----ICGRCWKIVSDFHT 67
            |.||:......  |.|.:....|..|.|..::.::|  ....:||:.    ||..||..|:|||.
  Fly     3 CRLCLNNVNDT--DTIRIFEDVGLSLNVANVLAKYF--WFEPKSDDPISTVICLTCWNQVNDFHQ 63

  Fly    68 LHEFVSAAQSSLQET----------KVALMEDDPLTQETTSFPEIIKLATQEEEGVTEPQELG-- 120
            .:..|.:|...|.|.          ||...||                :.|:||...|.||||
  Fly    64 FYVAVESAHRLLTERFSLKSGQDQGKVEHGED----------------SEQQEEEQDEDQELGLP 112

  Fly   121 ---GRNF----FYPEIKIEEHELDTLPRIEILERSANTQENQDQLEGAARRLRKRLKAEDGSSVD 178
               |.:|    |..|:              |.::...|..|..         :::...||.::|:
  Fly   113 GSEGGSFTNEQFLTEV--------------IAQQEQQTDSNPP---------KEQFIKEDNATVN 154

  Fly   179 KDKDEDGVEETAEPAPPKKRRGRPRKSDAAVA----PPQKPKEDIQLDLKAEELDEFVDEETDPD 239
            .       .||:...|.::|| ..|.:..:.|    ||..|.|
  Fly   155 D-------PETSATLPTEQRR-ETRSTAKSKAHHSLPPSTPPE---------------------- 189

  Fly   240 FSCLVPSDNSSEDDGGSDGFDSDSDFELDNGKQEFAVLPKRTVVRPKKYKKRTKPAEPKVRMSRE 304
                                                   |...|..|...||| |.:      .|
  Fly   190 ---------------------------------------KSNSVANKSKAKRT-PCK------AE 208

  Fly   305 LLEQRKKQQEEYDV----IIAKFFTSV-LPCAICN-------LLVHNFTEMQRHHRLTHQVDPGY 357
            ...|:.|:..:|..    |.||....: |.|.:|:       ||..:.  :|.|||      .||
  Fly   209 GTPQKSKRYADYKQCMLDIDAKISAHMRLTCDVCHEGQETFLLLCKHM--LQEHHR------KGY 265

  Fly   358 MMCCGRKFTQRKVLAEHVLVHWNPDHFKCSVCEKSFQNSRHLESHQQVHMDPAVKLTFSCDLCSK 422
            .:||.:||.:|..|.:|:..|.:|:.|||:.|:|.|.:.:.|.:|:.:...|..:.||.|:.|.|
  Fly   266 AICCNKKFYKRSFLTDHIDRHADPEKFKCTQCDKRFADKQCLRNHELLKHHPEEEKTFMCEQCPK 330

  Fly   423 TFLSKTAIDYHKLNKHVPKSEFKFTCSECNKKFLTERKLKNHMSSMHDPESTIICDKCGKQMRTK 487
            .:..:..:|.|:    |...|....|..|.::|..:..|..|:...|....| :||.|.:.:|.:
  Fly   331 RYTKQYLLDQHR----VIHKERNVVCDLCERRFPNQSLLCTHVKMAHGNYGT-MCDICAQVIRGR 390

  Fly   488 IILKKHQELMHSDKPRPEPELQQCQICGAWLKGMTGLKQHMKSIHVESAGEHRCHICAKVSPNAR 552
            ...::|| |.|:....|:   .||.|||:|.|....||:|::..:..:|   .|.:|.|||||..
  Fly   391 AAFQRHQ-LEHAGVTEPK---VQCDICGSWHKNKHSLKKHVRRHNGTAA---TCDLCGKVSPNRS 448

  Fly   553 ALRRHIYHNHECERKFKCTMCEKAFKRPQELKEHTSTHTGEVLYTCPNCPMTFFCSANMYKHRQR 617
            |:..|..:.|..:||.:|::|.||||:...|:||.:.|||||||.||:||.||..:||.:.||::
  Fly   449 AMLSHQRYVHLTDRKHECSVCNKAFKKAITLREHMTMHTGEVLYKCPHCPKTFNSNANQHTHRRK 513

  Fly   618 LHRAQYEADKN---------QPKPPNILKIS 639
            .|..::|..:.         :.:.|::|.||
  Fly   514 CHPKEFEEARKARTEKRKAIEEETPSVLTIS 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071	22/77 (29%)
		FYDLN_acid	<191..268	CDD:302856	9/80 (11%)
		C2H2 Zn finger	330..351	CDD:275368	8/27 (30%)
		C2H2 Zn finger	360..378	CDD:275368	7/17 (41%)
		LIM	361..>400	CDD:295319	14/38 (37%)
		C2H2 Zn finger	386..406	CDD:275368	6/19 (32%)
		zf-C2H2_8	389..465	CDD:292531	19/75 (25%)
		C2H2 Zn finger	417..438	CDD:275368	5/20 (25%)
		C2H2 Zn finger	448..465	CDD:275368	4/16 (25%)
		C2H2 Zn finger	477..498	CDD:275368	7/20 (35%)
		C2H2 Zn finger	511..532	CDD:275368	9/20 (45%)
		C2H2 Zn finger	541..562	CDD:275368	9/20 (45%)
		C2H2 Zn finger	570..590	CDD:275368	9/19 (47%)
		C2H2 Zn finger	598..619	CDD:275368	10/20 (50%)
CG15073	NP_611362.2	zf-AD	2..78	CDD:285071	22/78 (28%)
		C2H2 Zn finger	269..286	CDD:275368	6/16 (38%)
		C2H2 Zn finger	294..316	CDD:275368	6/21 (29%)
		C2H2 Zn finger	325..345	CDD:275368	6/23 (26%)
		C2H2 Zn finger	352..370	CDD:275368	5/17 (29%)
		C2H2 Zn finger	410..430	CDD:275368	9/19 (47%)
		C2H2 Zn finger	437..458	CDD:275368	9/20 (45%)
		C2H2 Zn finger	466..486	CDD:275368	9/19 (47%)
		C2H2 Zn finger	494..512	CDD:275368	9/17 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H134721
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000909
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24403
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	4.010