DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and Zfp74

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_001258268.1	Gene:	Zfp74 / 365224	RGDID:	1563223	Length:	683	Species:	Rattus norvegicus

Alignment Length:	618	Identity:	148/618 - (23%)
Similarity:	219/618 - (35%)	Gaps:	162/618 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 SFPEII-KLATQEEEGVTEPQELGGRNFFYPE--IKIEEHELDTLPRIEILERSANTQENQDQLE 159
            |.|::| ||..:||..|.|.:.|..|.   |.  :.|:||                 |:||::|
  Rat    52 SKPDVIFKLEQEEEPCVVEKEVLRRRR---PGEILGIDEH-----------------QKNQNRL- 95

  Fly   160 GAARRLRKRLKAEDGSSVDKDKDEDGVEETAEPAPPKKRRGRPRKSDAAVAP--PQKPKEDIQLD 222
                 ||:.||   |:.|..:.||                 ||:|.....:|  ...|......|
  Rat    96 -----LRQVLK---GTVVTHEADE-----------------RPKKFANTFSPNSDSVPSGHNLCD 135

  Fly   223 LKAEELDEFVDEETDPDFSCLVPSDNSSEDDGGSDGFDSDSDFELDNGKQEFAVLPKRTVVRPKK 287
                  .:.|.:..:||          |.|.|.:.....:..|:.|:.:|.|.......|:.|.|
  Rat   136 ------PDSVGKRAEPD----------SGDPGNAKQPSPEERFQEDDAEQPFHNSSPHFVLTPFK 184

  Fly   288 YKKRTKPAEPKVRMSR------------------------ELLEQRKKQQEEYDVIIAKFFTSVL 328
            .....|.....:.:.|                        :|:...|....:
  Rat   185 CNHCGKGFSQTLDLIRHLRVHTGGKLYECHQCGKGFSHKEKLINHHKLHSRD------------- 236

  Fly   329 PCAICNLLVHNFTEM---QRHHRLTHQVDPGYMMC--CGRKFTQRKVLAEHVLVHWNPDHFKCSV 388
            .|..||.....|.:|   .||.|: |..:..| :|  ||:.|:|:..|.:|..:|.....::|..
  Rat   237 QCYECNECGKTFIKMSNLMRHQRI-HTGEKPY-VCQECGKSFSQKSNLIDHEKIHTGEKPYECRE 299

  Fly   389 CEKSFQNSRHLESHQQVHMDPAVKLTFSCDLCSKTFLSKTAIDYHKLNKHVPKSEFK-------- 445
            |.|||...:.|.:||:||..   :..::|:.|.|.|....::..| :..|..:..:|
  Rat   300 CGKSFSQKQSLVAHQKVHTG---EKPYACNECGKAFPRIASLALH-MRSHTGEKPYKCDKCGKAF 360

  Fly   446 ------------------FTCSECNKKFLTERKLKNHMSSMHDPESTIICDKCGKQMRTKIILKK 492
                              :.||||.|.|.....|..|:.| |..|....|.:|.|....|.....
  Rat   361 SQFSMLIIHVRIHTGEKPYECSECGKAFSQSSALTVHIRS-HTGEKPYECKECRKSFSHKKNFIT 424

  Fly   493 HQELMHSDKPRPEPELQQCQICGAWLKGMTGLKQHMKSIHVESAGE--HRCHICAKVSPNARALR 555
            ||::...:||      ..|..||.....|:.|.:|.: ||   .||  :.|..|.|.......|
  Rat   425 HQKIHTREKP------YGCNECGKAFIQMSNLVRHQR-IH---TGEKPYLCKECGKAFSQKSNL- 478

  Fly   556 RHIYHN--HECERKFKCTMCEKAFKRPQELKEHTSTHTGEVLYTCPNCPMTFFCSANMYKH-RQR 617
              |.|.  |..|:.::|..|.|||.:.|....|...||||..|.|..|...|...|::..| |..
  Rat   479 --IAHEKIHSGEKPYECNECGKAFSQKQNFITHQKVHTGEKPYDCNKCGKAFSQIASLTLHLRSH 541

  Fly   618 LHRAQYEADK--NQPKPPNILKISRNASTQNKP 648
            .....||.||  ......::|.:...:.|..||
  Rat   542 TGERPYECDKCGKAFSQCSLLNLHMRSHTGEKP 574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856	13/78 (17%)
		C2H2 Zn finger	330..351	CDD:275368	8/23 (35%)
		C2H2 Zn finger	360..378	CDD:275368	7/19 (37%)
		LIM	361..>400	CDD:295319	12/38 (32%)
		C2H2 Zn finger	386..406	CDD:275368	8/19 (42%)
		zf-C2H2_8	389..465	CDD:292531	23/101 (23%)
		C2H2 Zn finger	417..438	CDD:275368	5/20 (25%)
		C2H2 Zn finger	448..465	CDD:275368	7/16 (44%)
		C2H2 Zn finger	477..498	CDD:275368	6/20 (30%)
		C2H2 Zn finger	511..532	CDD:275368	6/20 (30%)
		C2H2 Zn finger	541..562	CDD:275368	6/22 (27%)
		C2H2 Zn finger	570..590	CDD:275368	7/19 (37%)
		C2H2 Zn finger	598..619	CDD:275368	6/21 (29%)
Zfp74	NP_001258268.1	KRAB	8..68	CDD:214630	7/15 (47%)
		KRAB	8..47	CDD:279668
		C2H2 Zn finger	185..205	CDD:275368	2/19 (11%)
		COG5048	236..677	CDD:227381	98/372 (26%)
		C2H2 Zn finger	241..261	CDD:275368	7/20 (35%)
		zf-H2C2_2	253..278	CDD:290200	9/26 (35%)
		C2H2 Zn finger	269..289	CDD:275368	7/19 (37%)
		zf-H2C2_2	281..306	CDD:290200	8/24 (33%)
		C2H2 Zn finger	297..317	CDD:275368	8/19 (42%)
		zf-H2C2_2	309..332	CDD:290200	8/25 (32%)
		C2H2 Zn finger	325..345	CDD:275368	5/20 (25%)
		zf-H2C2_2	337..362	CDD:290200	3/25 (12%)
		C2H2 Zn finger	353..373	CDD:275368	0/19 (0%)
		zf-H2C2_2	365..390	CDD:290200	6/24 (25%)
		C2H2 Zn finger	381..401	CDD:275368	9/20 (45%)
		zf-H2C2_2	393..418	CDD:290200	8/25 (32%)
		C2H2 Zn finger	409..429	CDD:275368	6/19 (32%)
		C2H2 Zn finger	437..457	CDD:275368	6/20 (30%)
		zf-H2C2_2	449..474	CDD:290200	9/28 (32%)
		C2H2 Zn finger	465..485	CDD:275368	6/22 (27%)
		zf-H2C2_2	477..502	CDD:290200	10/27 (37%)
		C2H2 Zn finger	493..513	CDD:275368	7/19 (37%)
		zf-H2C2_2	505..530	CDD:290200	9/24 (38%)
		C2H2 Zn finger	521..541	CDD:275368	6/19 (32%)
		zf-H2C2_2	533..558	CDD:290200	6/24 (25%)
		C2H2 Zn finger	549..569	CDD:275368	3/19 (16%)
		zf-H2C2_2	562..586	CDD:290200	4/13 (31%)
		C2H2 Zn finger	577..597	CDD:275368
		zf-H2C2_2	589..614	CDD:290200
		C2H2 Zn finger	605..625	CDD:275368
		zf-H2C2_2	617..642	CDD:290200
		C2H2 Zn finger	633..653	CDD:275368
		zf-H2C2_2	645..670	CDD:290200
		C2H2 Zn finger	661..681	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910