DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and ZNF81

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_001365081.1	Gene:	ZNF81 / 347344	HGNCID:	13156	Length:	661	Species:	Homo sapiens

Alignment Length:	615	Identity:	147/615 - (23%)
Similarity:	222/615 - (36%)	Gaps:	138/615 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 PEIIKLATQEE-----EGVTEPQ--------------ELGGRNFFYPEIKIEEHELDTLPRI--- 142
            ||:|....|.|     ||....|              .:.|::.|:.|::.|:...|:|..|
Human    67 PEVIFKLEQGEGPWTLEGEAPHQSCSDGKFGIKPSQRRISGKSTFHSEMEGEDTRDDSLYSILEE 131

  Fly   143 --EILERSANTQENQDQLEGAARRLRKRLKAEDGSSVDKDKDEDGVEETAEPAP----PKKRRGR 201
              :..|:....||..::|......|.|::     .:.:.|.:.....:...|:|    .:|   |
Human   132 LWQDAEQIKRCQEKHNKLLSRTTFLNKKI-----LNTEWDYEYKDFGKFVHPSPNLILSQK---R 188

  Fly   202 PRKSDAAVAPPQKPKEDIQLDLK---AEELDEFVDEETDPDFSCLVPSDNSSEDDGGSDGFDSDS 263
            |.|.| :.....|...|:.:..|   |:.||:.:                     |....|..:|
Human   189 PHKRD-SFGKSFKHNLDLHIHNKSNAAKNLDKTI---------------------GHGQVFTQNS 231

  Fly   264 DFELDNGKQEFAVLPKRTVVRPKKYKKRTKPAEPKVRMSRELLEQRKK----QQEEYDVIIAKFF 324
            .:.....        ..|.|   |:.:|.:..  ||...:..|.|..|    ::........|.|
Human   232 SYSHHEN--------THTGV---KFCERNQCG--KVLSLKHSLSQNVKFPIGEKANTCTEFGKIF 283

  Fly   325 TSVLPCAICNLLVHNFTEMQRH-----HRLTHQV-----------------DPGYMMC--CGRKF 365
            |.         ..|.|...:.|     |.|:..|                 |....:|  ||:.|
Human   284 TQ---------RSHFFAPQKIHTVEKPHELSKCVNVFTQKPLLSIYLRVHRDEKLYICTKCGKAF 339

  Fly   366 TQRKVLAEHVLVHWNPDHFKCSVCEKSFQNSRHLESHQQVHMDPAVKLTFSCDLCSKTFLSKTAI 430
            .|...|..|...|.....:||:.|.|||.....|..||..|....:   |.|..|.|.|...:|:
Human   340 IQNSELIMHEKTHTREKPYKCNECGKSFFQVSSLLRHQTTHTGEKL---FECSECGKGFSLNSAL 401

  Fly   431 DYHKLNKHVPKSEFKFTCSECNKKFLTERKLKNHMSSMHDPESTIICDKCGKQMRTKIILKKHQE 495
            :.|   :.:...|....||||.|.|..:..|:.| ..:|..|.:.||.:||:....|..|..||.
Human   402 NIH---QKIHTGERHHKCSECGKAFTQKSTLRMH-QRIHTGERSYICTQCGQAFIQKAHLIAHQR 462

  Fly   496 LMHSDKPRPEPELQQCQICGAWLKGMTGLKQHMKSIHVESAGE--HRCHICAKVSPNARALRRHI 558
            :...:||      .:|..||......:.|:.| |.||   .||  :.|..|.|...|...|..|
Human   463 IHTGEKP------YECSDCGKSFPSKSQLQMH-KRIH---TGEKPYICTECGKAFTNRSNLNTH- 516

  Fly   559 YHNHECERKFKCTMCEKAFKRPQELKEHTSTHTGEVLYTCPNCPMTFFCSANMYKHRQRLHRAQY 623
            ..:|..|:.:.|..|.|||.......:|.:.||||..|.|.:|...|...:.:..| ||:|..:.
Human   517 QKSHTGEKSYICAECGKAFTDRSNFNKHQTIHTGEKPYVCADCGRAFIQKSELITH-QRIHTTEK 580

  Fly   624 -----EADKNQPKPPNILKISRNASTQNKP 648
                 :.:|:..|.|: ||:.:...|..||
Human   581 PYKCPDCEKSFSKKPH-LKVHQRIHTGEKP 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856	16/83 (19%)
		C2H2 Zn finger	330..351	CDD:275368	5/25 (20%)
		C2H2 Zn finger	360..378	CDD:275368	7/19 (37%)
		LIM	361..>400	CDD:295319	13/38 (34%)
		C2H2 Zn finger	386..406	CDD:275368	8/19 (42%)
		zf-C2H2_8	389..465	CDD:292531	23/75 (31%)
		C2H2 Zn finger	417..438	CDD:275368	6/20 (30%)
		C2H2 Zn finger	448..465	CDD:275368	7/16 (44%)
		C2H2 Zn finger	477..498	CDD:275368	7/20 (35%)
		C2H2 Zn finger	511..532	CDD:275368	6/20 (30%)
		C2H2 Zn finger	541..562	CDD:275368	6/20 (30%)
		C2H2 Zn finger	570..590	CDD:275368	6/19 (32%)
		C2H2 Zn finger	598..619	CDD:275368	6/20 (30%)
ZNF81	NP_001365081.1	KRAB	21..81	CDD:214630	5/13 (38%)
		C2H2 Zn finger	249..268	CDD:275368	5/20 (25%)
		C2H2 Zn finger	276..296	CDD:275368	5/28 (18%)
		C2H2 Zn finger	307..324	CDD:275368	1/16 (6%)
		C2H2 Zn finger	332..352	CDD:275368	7/19 (37%)
		COG5048	356..>651	CDD:227381	82/274 (30%)
		C2H2 Zn finger	360..380	CDD:275368	8/19 (42%)
		C2H2 Zn finger	388..408	CDD:275368	6/22 (27%)
		C2H2 Zn finger	416..436	CDD:275368	8/20 (40%)
		C2H2 Zn finger	444..464	CDD:275368	7/19 (37%)
		C2H2 Zn finger	472..492	CDD:275368	6/20 (30%)
		C2H2 Zn finger	500..520	CDD:275368	6/20 (30%)
		C2H2 Zn finger	528..548	CDD:275368	6/19 (32%)
		C2H2 Zn finger	556..576	CDD:275368	6/20 (30%)
		C2H2 Zn finger	584..604	CDD:275368	5/20 (25%)
		C2H2 Zn finger	612..632	CDD:275368
		C2H2 Zn finger	640..660	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910