DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4282 and CG12299

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_609448.1	Gene:	CG12299 / 34483	FlyBaseID:	FBgn0032295	Length:	736	Species:	Drosophila melanogaster

Alignment Length:	579	Identity:	120/579 - (20%)
Similarity:	215/579 - (37%)	Gaps:	122/579 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 PLTQETTSFPEIIKLATQEEEGVTEPQELGGR-----NFFYPEIKIEEHELDTL----------- 139
            |:.|:|...|:......|::....:|.:|...     .||...:.:.:| ::||
  Fly    18 PILQQTHLLPQQAPNPPQQQPQQPQPPDLTFHCMCCAEFFVHPLALYQH-MNTLHPHEPGNGQQE 81

  Fly   140 ----------------PRIEILERSANTQENQDQLEGAARRLRKRLKAEDGSSVDKDKDEDGVEE 188
                            |..|:.|      :..|..:|:|.      ...|.||...|.|:|..::
  Fly    82 QESPGDESEDYSWIFEPVCELAE------DGSDSSDGSAS------SGSDSSSSSDDDDDDDDDD 134

  Fly   189 TAEPAPPKKRRGR-----PRKSDAAVAPPQKPKEDIQLDLKAEELDEFVDEETDPDFSCLVPSDN 248
            ::..:........     |..|::.....|:..:.:...:.....:||..:.|||..|..:
  Fly   135 SSSSSSSSSNSSSSSSSVPTTSNSNTQQSQESVQPLHGLVAGPGYNEFQLQMTDPRESTSI---- 195

  Fly   249 SSEDDGGSDGFDSDSDFELDNGKQEFAVLPKRTVVRPKKYKKRTKPAEPKVRMSRELLEQRKKQQ 313
                                     |.|.|..:|...::.........|.:.:....:::|:.::
  Fly   196 -------------------------FMVQPTVSVTPLQQLLPPAPTVSPGLGLQSTPIKRRRGRR 235

  Fly   314 EEYDVIIAKFFTSVLPCAICNLLVHNFTEMQRHHRLTHQVDPGYMMCCGRKFTQRKVLAEHVLVH 378
            ......:..      |....|         |:..:.||         |...|.....|::||..|
  Fly   236 SNIGAPVMD------PALNGN---------QKCFQCTH---------CEASFPNAGDLSKHVRSH 276

  Fly   379 WNPDHFKCSVCEKSFQNSRHLESHQQVHMDPAVKLTFSCDLCSKTFLSKTAIDYHKLNKHVPKSE 443
            .....|:||:|:|:|.:...|.:|.::|   :.:..:.|:||.|.|...:::..|..:..|.|..
  Fly   277 ITNKPFQCSICQKTFTHIGSLNTHIRIH---SGEKPYKCELCPKAFTQSSSLMVHMRSHSVRKPH 338

  Fly   444 FKFTCSECNKKFLTERKLKNHMSSMHDPESTIICDKCGKQMRTKIILKKHQELMHSDKPRPEPEL 508
               .|.:|:|.|:....|..|..:...|..|.||.:|.::.:.:.:|.:|.. ||:     :..:
  Fly   339 ---QCVQCDKGFINYSSLLLHQKTHIAPTETFICPECEREFKAEALLDEHMR-MHT-----QELV 394

  Fly   509 QQCQICGAWLKGMTGLKQHMKSIHVESAGE--HRCHICAKVSPNARALRRHIYHNHECERKFKCT 571
            .||.||....:..:.|.||||: |:   ||  ..|.:|.:....:.:|..|: ..|..|:.|:|.
  Fly   395 YQCAICREAFRASSELVQHMKN-HM---GEKPFTCSLCDRSFTQSGSLNIHM-RIHTGEKPFQCK 454

  Fly   572 MCEKAFKRPQELKEHTSTHTGEVLYTCPNCPMTFFCSANMYKHRQRLHRAQYEADKNQP 630
            :|:|.|.:...|..|...|.||..|.||.|..::...|.:.||.|....|...:....|
  Fly   455 LCDKCFTQASSLSVHMKIHAGEKPYPCPICGKSYSQQAYLNKHIQAHQMASAASASTSP 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856	9/81 (11%)
		C2H2 Zn finger	330..351	CDD:275368	2/20 (10%)
		C2H2 Zn finger	360..378	CDD:275368	5/17 (29%)
		LIM	361..>400	CDD:295319	12/38 (32%)
		C2H2 Zn finger	386..406	CDD:275368	7/19 (37%)
		zf-C2H2_8	389..465	CDD:292531	19/75 (25%)
		C2H2 Zn finger	417..438	CDD:275368	6/20 (30%)
		C2H2 Zn finger	448..465	CDD:275368	5/16 (31%)
		C2H2 Zn finger	477..498	CDD:275368	4/20 (20%)
		C2H2 Zn finger	511..532	CDD:275368	8/20 (40%)
		C2H2 Zn finger	541..562	CDD:275368	4/20 (20%)
		C2H2 Zn finger	570..590	CDD:275368	6/19 (32%)
		C2H2 Zn finger	598..619	CDD:275368	7/20 (35%)
CG12299	NP_609448.1	COG5048	<254..413	CDD:227381	45/179 (25%)
		C2H2 Zn finger	256..276	CDD:275368	7/28 (25%)
		zf-H2C2_2	268..293	CDD:290200	10/24 (42%)
		C2H2 Zn finger	284..304	CDD:275368	7/19 (37%)
		zf-H2C2_2	296..321	CDD:290200	8/27 (30%)
		zf-C2H2_2	312..>387	CDD:289522	21/77 (27%)
		C2H2 Zn finger	312..332	CDD:275368	6/19 (32%)
		C2H2 Zn finger	340..360	CDD:275368	6/19 (32%)
		C2H2 Zn finger	369..389	CDD:275368	4/20 (20%)
		C2H2 Zn finger	397..417	CDD:275368	8/20 (40%)
		zf-H2C2_2	409..434	CDD:290200	10/28 (36%)
		C2H2 Zn finger	425..445	CDD:275368	4/20 (20%)
		zf-H2C2_2	437..462	CDD:290200	9/25 (36%)
		C2H2 Zn finger	453..473	CDD:275368	6/19 (32%)
		zf-H2C2_2	465..490	CDD:290200	9/24 (38%)
		C2H2 Zn finger	481..501	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910