DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4282 and Zfp335

DIOPT Version :9

Sequence 1:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_030107665.1	Gene:	Zfp335 / 329559	MGIID:	2682313	Length:	1338	Species:	Mus musculus

Alignment Length:	545	Identity:	117/545 - (21%)
Similarity:	182/545 - (33%)	Gaps:	166/545 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 PEIKIEEHELDTLPRIEILERSANTQENQDQLEGAARRLRKRLKAEDGSSVDKDKDEDGVEETAE 191
            ||.:.|:.::.....|:.||..::....:|:..|...||::
Mouse   305 PEEEEEDDDIVDAGAIDDLEEDSDYNPAEDEPRGRQLRLQR------------------------ 345

  Fly   192 PAP----PKKRRGRPRKSDAAVAPPQKPKEDIQLDLKAEELDEFVDEETDPDFSCLVPSDNSSED 252
            |.|    |::|.|||||.      |:....|:. |...:.|......::.|:...|....:|...
Mouse   346 PTPSTPRPRRRPGRPRKL------PRLETSDLH-DGVGQPLVSSQSTQSPPELQDLEAPSSSGLR 403

  Fly   253 DGGSDGFD------SDSDFELDNGK---QEFAVLPKRTVVRP------KKYKK-RTKPAEPKVRM 301
            ..|..|..      |.||.|  |..   |:.|..|.|...||      |||:| ..|..:|.:|
Mouse   404 ALGKVGRGLVESGVSQSDAE--NAAPSCQDEADAPPRRRGRPSRRFLGKKYRKYYYKSPKPLLR- 465

  Fly   302 SRELLEQRKKQQEEYDVIIAKFFTSVLP--CAIC--NLLVHNFTEMQRHHRLTHQV-DPGYMMC- 360
                                       |  |.||  ..|.|   |..|.|..:|:. ||....|
Mouse   466 ---------------------------PYLCRICGSRFLSH---EDLRFHVNSHEAGDPQLFRCL 500

  Fly   361 -CGRKFTQRKVLAEHVLVHWNPDHFKCSVCEKSFQNSRHLESHQQVHM-------DPAVKLTFSC 417
             |..:..:...|.||:..|.....:||..|..:....:.:..|..||.       ||..||:
Mouse   501 QCSYRSRRWSSLKEHMFNHVGSKPYKCDECSYTSVYRKDVIRHAAVHSQDRKKRPDPTPKLS--- 562

  Fly   418 DLCSKTFLSKTAIDYHKLNKHVPKSEFKFTCSECNKKFLTERKLKNHMSSMHDPESTIICDKCGK 482
                                       .|.|..|.:.:..:::|..||.: |..|...:||||||
Mouse   563 ---------------------------SFPCPVCGRVYPMQKRLTQHMKT-HSTEKPHMCDKCGK 599

  Fly   483 QMRTKIILKKHQELMHSDKPRPEPELQQCQICGAWLKGMTGLKQHMKSIHVESAGEHRCHICAKV 547
            ..:.:...|.|                              |..|::::   :....:|..|..|
Mouse   600 SFKKRYTFKMH------------------------------LLTHIQAV---ANRRFKCEFCEFV 631

  Fly   548 SPNARALRRHIYHNHECERKFKCTMCEKAFKRPQELKEHTST-HTGEVLYTCPNCPMTFFCSANM 611
            ..:.:||..| ..:|..::.|||:.|.....|...|..|.:. |||...:.|..|..:.....|:
Mouse   632 CEDKKALLNH-QLSHVSDKPFKCSFCPYRTFREDFLLSHVAVKHTGAKPFACEYCHFSTRHKKNL 695

  Fly   612 YKHRQRLHRAQYE--ADKNQPKPPN 634
            ..|.:..|...:|  ..::..:||:
Mouse   696 RLHVRCRHANSFEEWGRRHPEEPPS 720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856	22/86 (26%)
		C2H2 Zn finger	330..351	CDD:275368	8/22 (36%)
		C2H2 Zn finger	360..378	CDD:275368	5/19 (26%)
		LIM	361..>400	CDD:295319	8/38 (21%)
		C2H2 Zn finger	386..406	CDD:275368	3/19 (16%)
		zf-C2H2_8	389..465	CDD:292531	12/82 (15%)
		C2H2 Zn finger	417..438	CDD:275368	0/20 (0%)
		C2H2 Zn finger	448..465	CDD:275368	3/16 (19%)
		C2H2 Zn finger	477..498	CDD:275368	8/20 (40%)
		C2H2 Zn finger	511..532	CDD:275368	2/20 (10%)
		C2H2 Zn finger	541..562	CDD:275368	6/20 (30%)
		C2H2 Zn finger	570..590	CDD:275368	5/20 (25%)
		C2H2 Zn finger	598..619	CDD:275368	4/20 (20%)
Zfp335	XP_030107665.1	zf-H2C2_5	248..268	CDD:372805
		C2H2 Zn finger	469..489	CDD:275368	8/22 (36%)
		C2H2 Zn finger	499..519	CDD:275368	5/19 (26%)
		zf-H2C2_2	511..536	CDD:372612	7/24 (29%)
		zf-H2C2_5	525..548	CDD:372805	5/22 (23%)
		C2H2 Zn finger	527..547	CDD:275368	3/19 (16%)
		C2H2 Zn finger	566..586	CDD:275368	5/20 (25%)
		zf-H2C2_2	578..603	CDD:372612	11/25 (44%)
		C2H2 Zn finger	594..614	CDD:275368	9/49 (18%)
		C2H2 Zn finger	625..645	CDD:275368	6/20 (30%)
		C2H2 Zn finger	653..674	CDD:275368	5/20 (25%)
		C2H2 Zn finger	682..701	CDD:275368	4/18 (22%)
		C2H2 Zn finger	1022..1042	CDD:275368
		SFP1	<1027..1127	CDD:227516
		C2H2 Zn finger	1050..1070	CDD:275368
		zf-H2C2_5	1076..1100	CDD:372805
		C2H2 Zn finger	1078..1098	CDD:275368
		zf-H2C2_2	1090..1115	CDD:372612
		C2H2 Zn finger	1106..1127	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834456
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.030